PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 33939297-7 2021 More importantly, the treatment of wortmannin, an inhibitor of Akt/ERK pathway, abrogated nesfatin-1 effects on attenuating ER stress and H/R injury in H9c2 cells. Wortmannin 35-45 Eph receptor B1 Rattus norvegicus 67-70 28903412-6 2017 Phosphorylation of PI3K/Akt was attenuated in atorvastatin + IPC+ wortmannin group, phosphorylation of P42 MAPK/ERK was increased in atorvastatin+IPC and atorvastatin+IPC+wortmannin groups. Wortmannin 171-181 Eph receptor B1 Rattus norvegicus 112-115 27492364-11 2016 Wortmannin inhibited the phosphorylation of both Akt and ERK, whereas PD98059 suppressed the phosphorylation of ERK only. Wortmannin 0-10 Eph receptor B1 Rattus norvegicus 57-60 27538649-10 2016 Compared with the I/R+Xe group, the I/R+PD98059+Xe and I/R+wortmannin+Xe groups showed worse neurological outcomes and less p-Akt and p-ERK at each time point (P<0.05). Wortmannin 59-69 Eph receptor B1 Rattus norvegicus 136-139 26296503-7 2015 Pretreatment with wortmannin or PD98059 abrogated the protective effects of MPC and suppressed the phosphorylation of Akt, ERK and GSK-3beta. Wortmannin 18-28 Eph receptor B1 Rattus norvegicus 123-126 23200898-7 2013 Western blot analysis also showed that Danshensu increased phosphorylation of Akt and extracellular signal-related kinase 1/2 (ERK1/2) in H9c2 cells, and the protective effects of Danshensu were partially inhibited by phosphatidylinositol 3"-kinase (PI3K) specific inhibitor wortmannin or ERK specific inhibitor U0126. Wortmannin 275-285 Eph receptor B1 Rattus norvegicus 127-130 21680754-9 2011 Western blotting confirmed that phosphorylation of Akt and ERK were increased by 1CAO15 (which was inhibited by wortmannin), but not by 3CAO3 or ADO. Wortmannin 112-122 Eph receptor B1 Rattus norvegicus 59-62 17902169-9 2008 S1P-stimulated AP-1 subunits (c-Jun and c-Fos mRNA) expression was attenuated by U0126 and wortmannin, suggesting that MEK and PI3K/ERK cascade linking to AP-1 was involved in EGFR expression. Wortmannin 91-101 Eph receptor B1 Rattus norvegicus 132-135 17663741-7 2007 This response was dependent on Ras/ERK and PI3 K signaling because treatment with PD98059 together with wortmannin decreased promoter activity, in response to NGF, to the level exhibited by untreated cells. Wortmannin 104-114 Eph receptor B1 Rattus norvegicus 35-38 17434686-10 2007 Moreover, growth of neurites induced by octanoic acid was potently inhibited by treatment of cells with the p38 MAPK inhibitor SB203580 and the ERK kinase inhibitor PD98059 but not inhibited and only slightly inhibited by the JNK inhibitor SP600125 and the PI3K inhibitor wortmannin, respectively. Wortmannin 272-282 Eph receptor B1 Rattus norvegicus 144-147 17107963-7 2007 Further studies revealed that phosphatidylinositol 3-kinase inhibitors LY294002 and wortmannin induced phosphorylated ERK Tyr-204 and pMdm2 Ser-166 phosphorylations in hepatocytes in culture and in rat hepatocytes in vivo. Wortmannin 84-94 Eph receptor B1 Rattus norvegicus 118-121 15755557-5 2005 VEGF-induced gliotrophic effects were found to be mediated by the MAPK/ERK and PI-3 kinase signaling pathways, since the both the MEK1 inhibitor, PD98059 and the PI-3 kinase inhibitor, Wortmannin abolished VEGF-induced astrocytic GFAP(+) expression. Wortmannin 185-195 Eph receptor B1 Rattus norvegicus 71-74 15798216-11 2005 The inhibition of phosphatidylinositol 3-kinase (PI3K)-AKT signal transduction by Ly294002 and wortmannin significantly blocked c-Jun-regulated morphological transformation, while inhibition of basal MEK-ERK activity with PD98059 and U0126 had little effect. Wortmannin 95-105 Eph receptor B1 Rattus norvegicus 204-207 12623996-8 2003 Wortmannin, a PI3K inhibitor, inhibited EGF-mediated phosphorylation of ERK (IC50, approximately 14 nmol/L). Wortmannin 0-10 Eph receptor B1 Rattus norvegicus 72-75 12623996-9 2003 To examine the role of the EGFR in Ang II-mediated phosphorylation of ERK we utilized 100 nmol/L wortmannin to inhibit EGFR signaling to ERK and T19N RhoA to block Ang II-mediated ERK phosphorylation. Wortmannin 97-107 Eph receptor B1 Rattus norvegicus 70-73 12623996-9 2003 To examine the role of the EGFR in Ang II-mediated phosphorylation of ERK we utilized 100 nmol/L wortmannin to inhibit EGFR signaling to ERK and T19N RhoA to block Ang II-mediated ERK phosphorylation. Wortmannin 97-107 Eph receptor B1 Rattus norvegicus 137-140 12623996-9 2003 To examine the role of the EGFR in Ang II-mediated phosphorylation of ERK we utilized 100 nmol/L wortmannin to inhibit EGFR signaling to ERK and T19N RhoA to block Ang II-mediated ERK phosphorylation. Wortmannin 97-107 Eph receptor B1 Rattus norvegicus 137-140 12055094-3 2002 Inhibition of phospholipase C (PLC) by U-73122 or of phosphoinositide (PI) 3-kinase by wortmannin partially reduced ERK activation. Wortmannin 87-97 Eph receptor B1 Rattus norvegicus 116-119 11311983-5 2001 The activation of ERK by kainate was blocked by the ERK kinase (MEK) inhibitor PD98059, and the PI3 kinase inhibitor wortmannin, but not by the p38 MAP kinase inhibitor SB203580. Wortmannin 117-127 Eph receptor B1 Rattus norvegicus 18-21 10629859-7 1999 Among several inhibitors for analyzing intracellular signaling pathways, wortmannin inhibited the activation of ERK by H2O2 treatment. Wortmannin 73-83 Eph receptor B1 Rattus norvegicus 112-115 10330161-5 1999 In contrast, EGF-induced ERK activation was inhibited by the phosphatidylinositol-3-kinase inhibitor wortmannin, which had no effect upon FGF-induced ERK activation. Wortmannin 101-111 Eph receptor B1 Rattus norvegicus 25-28 8947482-5 1996 Application of wortmannin and agents to elevate intracellular cAMP levels also completely blocked Erk activation but were without effect on the biphasic [Ca2+]i response to hypo-osmotic treatment of the cells, suggesting a role of PtdIns 3-kinase and the Ras/Raf pathway downstream of the calcium signal. Wortmannin 15-25 Eph receptor B1 Rattus norvegicus 98-101