PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 15163435-1 2004 Dehydroepiandrosterone (DHEA) and its sulfate derivative DHEA-S are neurosteroids, produced in the brain, and neuroactive steroids, produced in the adrenals and affecting the brain. Sulfates 38-45 sulfotransferase family 2A member 1 Homo sapiens 57-63 15635504-1 2004 Dehydroepiandrosterone (DHEA) and its sulfate (DHEAS) are the main adrenal androgens (AAs) produced in humans. Sulfates 38-45 sulfotransferase family 2A member 1 Homo sapiens 47-52 15056284-1 2004 Dehydroepiandrosterone (DHEA) and its sulfate (DHEAS) are suggested to be important neurosteroids. Sulfates 38-45 sulfotransferase family 2A member 1 Homo sapiens 47-52 12642469-5 2003 On the other hand, expressed CYP3A7-mediated CBZ 10,11-epoxidation was activated by sulfate conjugate steroids, such as pregnenolone 3-sulfate, 17alpha-hydroxypregnenolone 3-sulfate, and dehydroepiandrosterone 3-sulfate (DHEA-S), whereas the unconjugated form corresponding to these three steroids did not activate the reaction. Sulfates 84-91 sulfotransferase family 2A member 1 Homo sapiens 221-227 14552823-6 2003 The concentrations of these sulfates in the sera of healthy male volunteers (n=14) were 19.2-245.3 mg/ml (Adiol-3S) and 0.175-5.16 microg/ml (DHEA-S), and those of patients with prostate cancer (n=19) were 15.3-182.7 ng/ml (Adiol-3S; four samples, not detectable) and 0.110-2.421 microg/ml (DHEA-S). Sulfates 28-36 sulfotransferase family 2A member 1 Homo sapiens 142-148 14552823-6 2003 The concentrations of these sulfates in the sera of healthy male volunteers (n=14) were 19.2-245.3 mg/ml (Adiol-3S) and 0.175-5.16 microg/ml (DHEA-S), and those of patients with prostate cancer (n=19) were 15.3-182.7 ng/ml (Adiol-3S; four samples, not detectable) and 0.110-2.421 microg/ml (DHEA-S). Sulfates 28-36 sulfotransferase family 2A member 1 Homo sapiens 291-297 15120419-0 2004 Dehydroepiandrosterone (DHEA) and its sulfate (DHEAS) inhibit the apoptosis in human peripheral blood lymphocytes. Sulfates 38-45 sulfotransferase family 2A member 1 Homo sapiens 47-52 11321667-1 2001 Cortisol and dehydroepiandrosterone (DHEA) and its sulphate (DHEAS) are the major steroid hormones produced by the human adrenal cortex. Sulfates 51-59 sulfotransferase family 2A member 1 Homo sapiens 61-66 12471606-7 2003 The fact that the MM-PBSA method reproduced the relative binding free energies of DHEAS, a steroid having a negatively charged sulfate group, and the neutrally charged TES, 5ADHT, and AND in satisfactory agreement with experiment shows the robustness of the method in predicting relative binding affinities. Sulfates 127-134 sulfotransferase family 2A member 1 Homo sapiens 82-87 12471606-11 2003 This is probably due to the hydrogen bonding interaction formed between the OH group of Tyr99H and the sulfate group of DHEAS. Sulfates 103-110 sulfotransferase family 2A member 1 Homo sapiens 120-125 12073561-2 2002 In contrast to most other hosts of dermatophytes, humans are characterized by a high cutaneous concentration of the adrenal androgen dehydroepiandrosterone (DHEA) and its sulphate (DHEAS). Sulfates 171-179 sulfotransferase family 2A member 1 Homo sapiens 181-186 11990382-1 2002 SULT2A1 catalyzes the sulfate conjugation of dehydroepiandrosterone (DHEA) as well as other steroids. Sulfates 22-29 sulfotransferase family 2A member 1 Homo sapiens 0-7 11695098-5 2001 With a daily dose of 50 mg DHEA, the plasma levels of DHEAS (the sulphate of DHEA) increase to levels within the normal range and beneficial effects have been demonstrated for several psychological parameters such as mood, fatigue, general well-being and sexual function. Sulfates 65-73 sulfotransferase family 2A member 1 Homo sapiens 54-59 11853289-3 2001 In plasma, where the major portion of these hormones is present in the sulfate form, it is possible that DHEAS serves as a reservoir for DHEA. Sulfates 71-78 sulfotransferase family 2A member 1 Homo sapiens 105-110 14561100-1 2003 Man and higher primates have adrenals that secrete large amounts of dehydroepiandrosterone (DHEA) [prasterone] and its sulphate (DHEAS) [PB 008]. Sulfates 119-127 sulfotransferase family 2A member 1 Homo sapiens 129-134 12398784-1 2002 INTRODUCTION: Dehydroepiandrosterone (DHEA) and its sulphate (DHEAS) are pleiotropic adrenal hormones with immunostimulating and antiglucocorticoid effects. Sulfates 52-60 sulfotransferase family 2A member 1 Homo sapiens 62-67 10403489-1 1999 Dehydroepiandrosterone (DHEA) and its sulfate (DHEA-S) are the most abundant steroidal products and major circulating steroids in humans. Sulfates 38-45 sulfotransferase family 2A member 1 Homo sapiens 47-53 10211606-2 1999 DHEA and its sulfate (DHEA-S) are secreted in approximately equal amounts, but serum levels of DHEA-S are 300-500 times higher and have no diurnal variation when compared to DHEA. Sulfates 13-20 sulfotransferase family 2A member 1 Homo sapiens 22-28 10211606-2 1999 DHEA and its sulfate (DHEA-S) are secreted in approximately equal amounts, but serum levels of DHEA-S are 300-500 times higher and have no diurnal variation when compared to DHEA. Sulfates 13-20 sulfotransferase family 2A member 1 Homo sapiens 95-101 10940758-4 2000 Conversely, dehydroepiandrosterone (DHEA) and its sulfate (DHEAS) are believed to antagonize noxious glucocorticoid effects and exert a neuroprotective activity. Sulfates 50-57 sulfotransferase family 2A member 1 Homo sapiens 59-64 8222492-8 1993 The existence of a subgroup of subjects with a high level of DHEA ST enzymatic activity in liver and a 4.6-fold range in this activity have implications for individual differences in the sulfate conjugation of endogenous and exogenously administered steroid hormones and raise the possibility of pharmacogenetic regulation of this important enzyme in humans. Sulfates 187-194 sulfotransferase family 2A member 1 Homo sapiens 61-68 9545554-1 1998 Dehydroepiandrosterone (DHEA) and its sulfate (DHEA-S) are the most abundant steroids in humans, and their serum concentrations progressively decrease with age. Sulfates 38-45 sulfotransferase family 2A member 1 Homo sapiens 47-53 9444968-1 1998 DHEA, an adrenocortical steroid, and its sulfate derivative (DHEA-S), have been implicated in many biological functions, including the regulation of bone mass. Sulfates 41-48 sulfotransferase family 2A member 1 Homo sapiens 61-67 8185618-3 1994 Although two of these enzymes, DHEA ST and one form of PST, can catalyze the sulfate conjugation of estrogens, our goal was to test the hypothesis that human liver might also contain a distinct estrogen ST (EST). Sulfates 77-84 sulfotransferase family 2A member 1 Homo sapiens 31-38 9626121-1 1998 Women with adrenal insufficiency suffer from chronic dehydroepiandrosterone (sulfate) [DHEA(S)] deficiency. Sulfates 77-84 sulfotransferase family 2A member 1 Homo sapiens 87-94 9583004-1 1998 BACKGROUND: Though among the most abundant human steroid hormones, the physiologic role of dehydroepiandrosterone and its sulfate (DHEAS) is not known. Sulfates 122-129 sulfotransferase family 2A member 1 Homo sapiens 131-136 9539798-1 1998 Dehydroepiandrosterone (DHEA) and its sulfate derivative (DHEAS) are the most abundant steroids produced by the human adrenal, but no receptors have been identified for these steroids, and no function for them has been established, other than as precursors for sex steroid synthesis. Sulfates 38-45 sulfotransferase family 2A member 1 Homo sapiens 58-63 9215277-1 1997 The adrenal steroids, dehydroepiandrosterone (DHEA) and its sulfate (DHEAS), have attracted attention for their possible antiaging effects. Sulfates 60-67 sulfotransferase family 2A member 1 Homo sapiens 69-74 9024954-1 1997 Dehydroepiandrosterone (DHEA) and its sulfate, DHEA-S, are plentiful adrenal steroid hormones that decrease with aging and may have significant neuropsychiatric effects. Sulfates 38-45 sulfotransferase family 2A member 1 Homo sapiens 47-53 1588921-12 1992 Cloning of cDNA for this important human sulfate-conjugating enzyme will enhance understanding of the relationship between DHEA ST and other human liver STs, as well as ST enzymes in other species. Sulfates 41-48 sulfotransferase family 2A member 1 Homo sapiens 123-130 31445882-3 2019 SULT2A1 is one of the most abundant hepatic sulfotransferases and it catalyzes the sulfate conjugation of many endogenous substrates, such as bile acids and steroids. Sulfates 83-90 sulfotransferase family 2A member 1 Homo sapiens 0-7 31347187-1 2019 The clinical significance of dehydroepiandrosterone (DHEA) and its sulphate (DHEAS) in coronary heart disease (CHD) has not been thoroughly elucidated to date. Sulfates 67-75 sulfotransferase family 2A member 1 Homo sapiens 77-82 29334627-1 2018 Neuroactive steroids, including testosterone, dehydroepiandrosterone (DHEA) and its sulfate (DHEA-S) might play an important role in the pathophysiology of schizophrenia. Sulfates 84-91 sulfotransferase family 2A member 1 Homo sapiens 93-99 29528519-1 2018 The adrenal-derived hormones dehydroepiandrosterone (DHEA) and its sulfate (DHEAS) are the most abundant circulating hormones and their levels decline substantially with age. Sulfates 67-74 sulfotransferase family 2A member 1 Homo sapiens 76-81 28807679-7 2017 Collectively, these results imply that both Sult2st2 and Sult2st3 have evolved to sulfate specifically C27-bile alcohol, 5alpha-cyprinol, in Cypriniform fish, whereas the enzymatic characteristics of zebrafish Sult3 members, particularly Sult3st4, correlated with those of human SULT2A1. Sulfates 82-89 sulfotransferase family 2A member 1 Homo sapiens 279-286 29460795-9 2018 Sulfate plus glutathione normally sulfate fetal adrenal androgen dehydroepiandrosterone to DHEAS - major precursor of placental/postnatal estrogens. Sulfates 0-7 sulfotransferase family 2A member 1 Homo sapiens 91-96 27414183-7 2017 The sulfate conjugation by SULT2A1 also contributed to the metabolism of TAK-438 to form TAK-438 N-sulfate, and CYP2C9 mediated the formation of M-IV-Sul from TAK-438 N-sulfate. Sulfates 4-11 sulfotransferase family 2A member 1 Homo sapiens 27-34 25594860-1 2015 CONTEXT: PAPSS2 (PAPS synthase 2) provides the universal sulfate donor PAPS (3"-phospho-adenosine-5"-phosphosulfate) to all human sulfotransferases, including SULT2A1, responsible for sulfation of the crucial androgen precursor dehydroepiandrosterone (DHEA). Sulfates 57-64 sulfotransferase family 2A member 1 Homo sapiens 159-166 28276592-1 2017 The adrenal-derived hormones dehydroepiandrosterone (DHEA) and its sulfate (DHEAS) are the most abundant circulating hormones and their levels decline substantially with age. Sulfates 67-74 sulfotransferase family 2A member 1 Homo sapiens 76-81 26666359-2 2016 The enzyme steroid sulfatase (STS) cleaves the sulfate group of DHEAS and E1S leading to biosynthesis of endogenous hormones such as testosterone and estrone. Sulfates 47-54 sulfotransferase family 2A member 1 Homo sapiens 64-69 26938818-1 2016 Neurosteroid dehydropiandrosterone (DHEA) and its sulphate (DHEAS) are reported to have modulatory effects on neuronal excitabillity and synaptic plasticity. Sulfates 50-58 sulfotransferase family 2A member 1 Homo sapiens 60-65 26600008-1 2016 Early timing of adrenarche, associated with relatively high levels of dehydroepiandrosterone (DHEA) and its sulphate (DHEA-S) in children, has been linked with mental health problems, particularly anxiety. Sulfates 108-116 sulfotransferase family 2A member 1 Homo sapiens 118-124 25009533-1 2014 The adrenal steroid dehydroepiandrosterone (DHEA) and its sulfate (DHEAS) are two of the most abundant hormones in the human circulation. Sulfates 58-65 sulfotransferase family 2A member 1 Homo sapiens 67-72 25553402-1 2015 BACKGROUND: Previous evidence has shown that adrenal androgens, dehydroepiandrosterone (DHEA) and its sulfate derivative (DHEAS) have significant functions related to the control of mood, affect, and anxiety. Sulfates 102-109 sulfotransferase family 2A member 1 Homo sapiens 122-127 24794824-1 2015 The adrenal prohormone dehydroepiandrosterone (DHEA) and its sulphate conjugate (DHEAS) steadily decrease with age by 10% per decade reaching a nadir after the age of 80. Sulfates 61-69 sulfotransferase family 2A member 1 Homo sapiens 81-86 26680489-3 2015 In the present study we evaluate the role of steroid sulfotransferase SULT2A1 in the pathophysiology of AD on the basis of circulating steroids (measured by GC-MS), in which the sulfation catalyzed by SULT2A1 dominates over glucuronidation (pregnenolone/sulfate, DHEA/sulfate, androstenediol/sulfate and 5alpha-reduced pregnane and androstane catabolites). Sulfates 254-261 sulfotransferase family 2A member 1 Homo sapiens 70-77 26680489-3 2015 In the present study we evaluate the role of steroid sulfotransferase SULT2A1 in the pathophysiology of AD on the basis of circulating steroids (measured by GC-MS), in which the sulfation catalyzed by SULT2A1 dominates over glucuronidation (pregnenolone/sulfate, DHEA/sulfate, androstenediol/sulfate and 5alpha-reduced pregnane and androstane catabolites). Sulfates 268-275 sulfotransferase family 2A member 1 Homo sapiens 70-77 26680489-3 2015 In the present study we evaluate the role of steroid sulfotransferase SULT2A1 in the pathophysiology of AD on the basis of circulating steroids (measured by GC-MS), in which the sulfation catalyzed by SULT2A1 dominates over glucuronidation (pregnenolone/sulfate, DHEA/sulfate, androstenediol/sulfate and 5alpha-reduced pregnane and androstane catabolites). Sulfates 268-275 sulfotransferase family 2A member 1 Homo sapiens 70-77 23751811-1 2013 Dehydroepiandrosterone (DHEA) and its sulfate, DHEAS, are the most abundant steroid hormones in primates, providing a large reservoir of precursors for the production of androgens. Sulfates 38-45 sulfotransferase family 2A member 1 Homo sapiens 47-52 20686829-4 2011 Dehydroepiandrosterone and its sulfate derivative (DHEA-S) appear to have regulatory effects in immune homeostasis and are regulated by the nervous system, and it is suggested that they may be an integral element of neuroimmunomodulation. Sulfates 31-38 sulfotransferase family 2A member 1 Homo sapiens 51-57 19627466-2 2009 Together with its sulfate version, DHEA-sulfate (DHEAS), it is the most abundant steroid in humans. Sulfates 18-25 sulfotransferase family 2A member 1 Homo sapiens 49-54 18445661-2 2008 CYP3A7 metabolizes dehydroepiandrosterone and its sulfate (DHEAS). Sulfates 50-57 sulfotransferase family 2A member 1 Homo sapiens 59-64 17604586-1 2007 Dehydroepiandrosterone (DHEA) and its sulfate form (DHEAS) have been the focus of considerable publicity because of their demonstrated associations with a broad range of health outcomes. Sulfates 38-45 sulfotransferase family 2A member 1 Homo sapiens 52-57 23818143-3 2013 Consistent with this framework, researchers have nominated the adrenal androgen dehydroepiandrosterone (DHEA) and its sulfate (DHEAS), which can be peripherally converted to estrogen, as a biomarker of aging in humans and other primates. Sulfates 118-125 sulfotransferase family 2A member 1 Homo sapiens 127-132 22703301-1 2012 Human SULT2A1 is one of two predominant sulfotransferases in liver and catalyzes transfer of the sulfuryl moiety (-SO(3)) from activated sulfate (PAPS, 3"-phosphoadenosine 5-phosphosulfate) to hundreds of acceptors (metabolites and xenobiotics). Sulfates 137-144 sulfotransferase family 2A member 1 Homo sapiens 6-13 21411558-1 2011 CONTEXT: It has been proposed that because dehydroepiandrosterone (DHEA) and its sulfate, DHEAS, are important precursors for estrogen and androgen production, treatment with DHEA is a physiologically based strategy for the alleviation of hormone deficiency symptoms in postmenopausal women. Sulfates 81-88 sulfotransferase family 2A member 1 Homo sapiens 90-95 19299840-1 2009 Dehydroepiandrosterone (DHEA) and its sulfate (DHEAS) are hormones produced by the adrenal cortex that decline in concentration with age. Sulfates 38-45 sulfotransferase family 2A member 1 Homo sapiens 47-52 16735495-1 2006 CONTEXT: Dehydroepiandrosterone (DHEA) and its sulfate (DHEAS) decrease with aging and are important androgen and estrogen precursors in older adults. Sulfates 47-54 sulfotransferase family 2A member 1 Homo sapiens 56-61 16293666-1 2006 Dehydroepiandrosterone and its sulfate (DHEAS) are sex hormone precursors that exert marked neurotrophic and/or neuroprotective activity in the central nervous system. Sulfates 31-38 sulfotransferase family 2A member 1 Homo sapiens 40-45 16869261-1 2006 Of all steroidal hormones, dehydroepiandrosterone (DHEA) and its sulphate form, DHEAS, are synthesized by the adrenal glands in the biggest quantities. Sulfates 65-73 sulfotransferase family 2A member 1 Homo sapiens 80-85 15870835-1 2005 Dehydroepiandrosterone (DHEA) or their sulfate conjugate (DHEAS) (together abbreviated DHEA(S)) exert multiple effects in the central nervous system, and may be involved in the pathophysiological processes in schizophrenia. Sulfates 39-46 sulfotransferase family 2A member 1 Homo sapiens 58-63 15657092-2 2005 The concentrations of DHEA and its sulfate (DHEA-S) in serum reach a peak between the ages of 25 and 30 yr and thereafter decline steadily. Sulfates 35-42 sulfotransferase family 2A member 1 Homo sapiens 44-50