PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
8544018-1	1995	This study evaluated the effects of basic fibroblast growth factor, transforming growth factor-beta 1, insulin-like growth factor-1, and insulin on the incorporation of thymidine and sulfate in human osteoarthritic articular cartilage.	Sulfates	183-190	insulin	Homo sapiens	103-110	
8544018-9	1995	Compared with growth factor-free controls, insulin maximally increased thymidine incorporation by a factor (+/- SEM) of 2.36 +/- 0.47 and 1.69 +/- 0.19 in nonfibrillated and fibrillated explants, respectively; sulfate incorporation was maximally increased 1.60 +/- 0.24 and 1.92 +/- 0.29-fold for nonfibrillated and fibrillated explants, respectively.	Sulfates	210-217	insulin	Homo sapiens	43-50	
14495103-0	1961	[On the inactivation of insulin by sulfate ions].	Sulfates	35-42	insulin	Homo sapiens	24-31	
2666211-7	1989	Compared to saline, growth hormone and insulin treatment significantly enhanced body weights, nose-rump lengths, the widths of the proximal tibia growth plates and the incorporation of sulfate into rib cartilage.	Sulfates	185-192	insulin	Homo sapiens	39-46	
6384255-10	1984	Uremic serum fractions blunted cartilage sulfate uptake that was stimulated by whole serum, somatomedins (dissociated from serum carrier proteins), and insulin and lowered uridine and thymidine uptake that was stimulated by whole serum (all P less than 0.005).	Sulfates	41-48	insulin	Homo sapiens	152-159	
6360757-3	1983	To eliminate this problem, insulin sulfation was carried out in the organic solvent dimethylformamide in the presence of condensing agents such as N,N"-dicyclohexyl carbodiimide (DCC) and a sulfate donor.	Sulfates	190-197	insulin	Homo sapiens	27-34	
7852539-1	1995	To determine whether a reduction in insulinemia would be associated with a rise in serum dehydroepiandrosterone (DHEA) sulfate in insulin-resistant men, 29 middle-aged (30-59 yr old) and 28 elderly (60-80 yr old) hypertensive men were enrolled into a single blind, placebo-controlled study, in which benfluorex was administered to improve insulin sensitivity and reduce circulating insulin.	Sulfates	119-126	insulin	Homo sapiens	36-43	
1613425-1	1992	Our previous studies have shown that mammalian and salmon insulins stimulate sulphate uptake by cultured eel cartilage, suggesting the possible involvement of insulin in the regulation of cartilage matrix synthesis.	Sulfates	77-85	insulin	Homo sapiens	58-65	
17702734-12	2007	After adjustment for age, gender, creatinine clearance, urine sulfate, and body mass index, a significant inverse relationship was noted between 24-h urine pH and the degree of insulin resistance.	Sulfates	62-69	insulin	Homo sapiens	177-184	
24988354-2	2014	In this work, we characterize the aggregation process of human insulin at acidic pH in the presence of sulfate ions using a combination of Thioflavin T fluorescence, dynamic light scattering, size exclusion chromatography, Fourier transform infrared spectroscopy, and transmission electron microscopy.	Sulfates	103-110	insulin	Homo sapiens	63-70	
24988354-3	2014	It is found that the increase of sulfate concentration inhibits the conversion of insulin molecules into aggregates by modifying the aggregation pathway.	Sulfates	33-40	insulin	Homo sapiens	82-89	
24988354-5	2014	When the sulfate concentration is increased above 5 mM, the sulfate anion induces the salting-out of ~18-20% of insulin molecules into reversible amorphous aggregates, which retain a large content of alpha-helix structures.	Sulfates	9-16	insulin	Homo sapiens	112-119	
18509682-0	2008	The phytoestrogens daidzein and genistein enhance the insulin-stimulated sulfate uptake in articular chondrocytes.	Sulfates	73-80	insulin	Homo sapiens	54-61	
31680542-1	2019	The existence of insulin-like growth factors (IGFs) was recognized in connection with the stimulation of sulfate incorporation into cartilage.	Sulfates	105-112	insulin	Homo sapiens	17-24	
27668526-1	2016	Studies on the time course of ACTH- or insulin-induced hypoglycemia stimulating adrenal androgens are usually limited to dehydroepiandrosterone and/or its sulphate.	Sulfates	155-163	insulin	Homo sapiens	39-46	
24821967-1	2014	The SLC13 transporter family, whose members play key physiological roles in the regulation of fatty acid synthesis, adiposity, insulin resistance, and other processes, catalyzes the transport of Krebs cycle intermediates and sulfate across the plasma membrane of mammalian cells.	Sulfates	225-232	insulin	Homo sapiens	127-134	
18509682-8	2008	Although insulin raised the sodium [35S]sulfate uptake significantly, different concentrations of daidzein, genistein, or 17beta-estradiol showed no significant effects.	Sulfates	40-47	insulin	Homo sapiens	9-16	
18509682-9	2008	However, the stimulating effect of insulin on sulfate incorporation was enhanced significantly after preincubation of cells with 10(-11) M-10(-5) M daidzein or 10(-9) M-10(-5) M genistein but not by 17beta-estradiol.	Sulfates	46-53	insulin	Homo sapiens	35-42	
12657786-0	2003	Crystallographic titration of cubic insulin crystals: pH affects GluB13 switching and sulfate binding.	Sulfates	86-93	insulin	Homo sapiens	36-43