PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
31524278-0	2019	FKBP3 mediates oxaliplatin resistance in colorectal cancer cells by regulating HDAC2 expression.	Oxaliplatin	15-26	FKBP prolyl isomerase 3	Homo sapiens	0-5	
31524278-12	2019	Our data revealed that oxaliplatin resistance in CRC cells is positively associated with FKBP3 and HDAC2 expression, and FKBP3 downregulation could attenuate oxaliplatin resistance in CRC cells by reducing HDAC2 expression and possibly through regulation of the PTEN/AKT pathway.	Oxaliplatin	158-169	FKBP prolyl isomerase 3	Homo sapiens	121-126	
31524278-4	2019	However, the role of FKBP3 and HDAC2 in oxaliplatin resistance in CRC and the potential molecular mechanisms are still poorly understood.	Oxaliplatin	40-51	FKBP prolyl isomerase 3	Homo sapiens	21-26	
31524278-9	2019	Downregulation of FKBP3 significantly increased the sensitivity of primary CRC cells to oxaliplatin, reduced expression of HDAC2, permeability glycoprotein (P-gp) and phosphorylated AKT (p-AKT), and increased expression of phosphatase and tensin homolog (PTEN) and cleaved caspase-3.	Oxaliplatin	88-99	FKBP prolyl isomerase 3	Homo sapiens	18-23	
31524278-11	2019	Furthermore, downregulation of HDAC2 significantly counteracted FKBP3-induced oxaliplatin resistance in CRC cells.	Oxaliplatin	78-89	FKBP prolyl isomerase 3	Homo sapiens	64-69	
31524278-12	2019	Our data revealed that oxaliplatin resistance in CRC cells is positively associated with FKBP3 and HDAC2 expression, and FKBP3 downregulation could attenuate oxaliplatin resistance in CRC cells by reducing HDAC2 expression and possibly through regulation of the PTEN/AKT pathway.	Oxaliplatin	23-34	FKBP prolyl isomerase 3	Homo sapiens	89-94