PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 27089946-4 2016 Herein, we propose a novel therapeutic strategy using poly(glycidyl methacrylate) nanoparticles decorated with poly(acrylic acid) that enable dual delivery of docetaxel and interference peptides designed to block or inhibit EN1 (EN1-iPep). Docetaxel 159-168 engrailed homeobox 1 Homo sapiens 224-227 31055077-2 2019 Many TNBC acquire chemotherapy resistance, notably docetaxel, which has been associated with the overexpression of transcription factors (TFs), such as ENGRAILED1 (EN1). Docetaxel 51-60 engrailed homeobox 1 Homo sapiens 164-167 31055077-3 2019 Here, we have developed a tumor delivery system for docetaxel-PGMA-PAA-nanoparticles and interference peptides designed to specifically inhibit EN1 (EN1-iPeps). Docetaxel 52-61 engrailed homeobox 1 Homo sapiens 144-147 31055077-3 2019 Here, we have developed a tumor delivery system for docetaxel-PGMA-PAA-nanoparticles and interference peptides designed to specifically inhibit EN1 (EN1-iPeps). Docetaxel 52-61 engrailed homeobox 1 Homo sapiens 149-152 31055077-7 2019 Furthermore, docetaxel nanoparticles functionalized with EN1-RGD-iPeps significantly reduced TNBC growth both in vitro and in vivo without showing toxicity. Docetaxel 13-22 engrailed homeobox 1 Homo sapiens 57-60 27089946-4 2016 Herein, we propose a novel therapeutic strategy using poly(glycidyl methacrylate) nanoparticles decorated with poly(acrylic acid) that enable dual delivery of docetaxel and interference peptides designed to block or inhibit EN1 (EN1-iPep). Docetaxel 159-168 engrailed homeobox 1 Homo sapiens 229-237 27089946-6 2016 Furthermore, we show that treatment with EN1-iPep results in a highly synergistic pharmacological interaction with docetaxel in inhibiting cancer cell growth. Docetaxel 115-124 engrailed homeobox 1 Homo sapiens 41-49