PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
24058878-8	2013	Furthermore, we find that the ability of docetaxel to increase cyclin B1/Cdk1-mediated phosphorylation of Bcl-2/Bcl-xL and decrease Mcl-1 is required for ABT-737 to enhance apoptosis in PC3 cells, as determined by addition of Cdk1 inhibitor purvalanol A and expression of shRNA specific for cyclin B1.	Docetaxel	41-50	MCL1 apoptosis regulator, BCL2 family member	Homo sapiens	132-137	
21773733-0	2012	A novel histone deacetylase inhibitor, CG200745, potentiates anticancer effect of docetaxel in prostate cancer via decreasing Mcl-1 and Bcl-XL.	Docetaxel	82-91	MCL1 apoptosis regulator, BCL2 family member	Homo sapiens	126-131	
21914853-8	2011	The ability of navitoclax to synergize with docetaxel or erlotinib corresponded to an altered sensitivity of the mitochondria toward navitoclax, which was associated with the downmodulation of Mcl-1 and/or upregulation of Bim.	Docetaxel	44-53	MCL1 apoptosis regulator, BCL2 family member	Homo sapiens	193-198	
22490358-12	2012	CONCLUSIONS: The combination of ABT-737 with docetaxel can synergistically inhibit the proliferation of PC-3 cells through inducing apoptosis, which may be associated with cell cycle arrest, down-regulation of Bcl-2, Bcl-xL and Mcl-1 expression and activation of caspase-3.	Docetaxel	45-54	MCL1 apoptosis regulator, BCL2 family member	Homo sapiens	228-233	
16969094-9	2006	Moreover, combination of Mcl-1 AS oligonucleotide with docetaxel or cisplatin displayed synergistic anti-tumor activity.	Docetaxel	55-64	MCL1 apoptosis regulator, BCL2 family member	Homo sapiens	25-30	
21159614-0	2010	Contrasting effects of nutlin-3 on TRAIL- and docetaxel-induced apoptosis due to upregulation of TRAIL-R2 and Mcl-1 in human melanoma cells.	Docetaxel	46-55	MCL1 apoptosis regulator, BCL2 family member	Homo sapiens	110-115	
21159614-9	2010	Collectively, these results show that nutlin-3 may be a useful agent in combination with TRAIL and, importantly, uncover a novel regulatory effect of p53 on the expression of Mcl-1 in melanoma cells on treatment with nutlin-3, which may antagonize the therapeutic efficacy of other chemotherapeutic drugs in addition to docetaxel in melanoma.	Docetaxel	320-329	MCL1 apoptosis regulator, BCL2 family member	Homo sapiens	175-180	
18789152-0	2008	Enhancement of docetaxel-induced cytotoxicity and apoptosis by all-trans retinoic acid (ATRA) through downregulation of survivin (BIRC5), MCL-1 and LTbeta-R in hormone- and drug resistant prostate cancer cell line, DU-145.	Docetaxel	15-24	MCL1 apoptosis regulator, BCL2 family member	Homo sapiens	138-143	
18691406-0	2008	Zoledronic acid increases docetaxel cytotoxicity through pMEK and Mcl-1 inhibition in a hormone-sensitive prostate carcinoma cell line.	Docetaxel	26-35	MCL1 apoptosis regulator, BCL2 family member	Homo sapiens	66-71	
18691406-10	2008	CONCLUSION: The zoledronic acid-docetaxel combination produced a highly significant synergistic effect on the LNCaP cell line grown in normal or hormone-deprived medium, the principal molecular mechanisms involved being apoptosis and decreased pMEK and Mcl-1 expression.	Docetaxel	32-41	MCL1 apoptosis regulator, BCL2 family member	Homo sapiens	253-258	
30937691-0	2019	Correction to: A novel histone deacetylase inhibitor, CG200745, potentiates anticancer effect of docetaxel in prostate cancer via decreasing Mcl-1 and Bcl-XL.	Docetaxel	97-106	MCL1 apoptosis regulator, BCL2 family member	Homo sapiens	141-146	
28032735-5	2016	The IC50 values for docetaxel and stattic were 3.7 +- 0.9 nM and 4.6+-0.8 muM, respectively.Evaluation of key gene expression levels revealed a noticeable decrease in antiapoptotic Bcl-2 and Mcl-1 along withan increase in pro-apoptotic Bax mRNA levels (p<0.05).	Docetaxel	20-29	MCL1 apoptosis regulator, BCL2 family member	Homo sapiens	191-196	
30250075-5	2018	Further studies revealed that cells with a low MCL-1 expression had low mitochondrial priming, and treatment with the chemotherapy drug docetaxel raised the mitochondrial priming level and consequently sensitized cells to ABT-263.	Docetaxel	136-145	MCL1 apoptosis regulator, BCL2 family member	Homo sapiens	47-52