PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 34181104-7 2021 The immunoassay techniques were used to investigate Apaf-1 and cytochrome c levels, and different apoptosis assay methods applied to better understand the effect of Apaf-1 expression levels in cellular response to apoptotic stimuli by Docetaxel. Docetaxel 235-244 apoptotic peptidase activating factor 1 Homo sapiens 165-171 34181104-8 2021 Our results determined that cytoplasmic cytochrome c level elevated along with increasing Apaf-1 and MCF7 cells were sensitised to Docetaxel, suggesting that loss of Apaf-1 may cause Docetaxel-resistance in breast cancer cells through less apoptosome formation. Docetaxel 131-140 apoptotic peptidase activating factor 1 Homo sapiens 90-96 34181104-8 2021 Our results determined that cytoplasmic cytochrome c level elevated along with increasing Apaf-1 and MCF7 cells were sensitised to Docetaxel, suggesting that loss of Apaf-1 may cause Docetaxel-resistance in breast cancer cells through less apoptosome formation. Docetaxel 131-140 apoptotic peptidase activating factor 1 Homo sapiens 166-172 34181104-8 2021 Our results determined that cytoplasmic cytochrome c level elevated along with increasing Apaf-1 and MCF7 cells were sensitised to Docetaxel, suggesting that loss of Apaf-1 may cause Docetaxel-resistance in breast cancer cells through less apoptosome formation. Docetaxel 183-192 apoptotic peptidase activating factor 1 Homo sapiens 90-96 34181104-8 2021 Our results determined that cytoplasmic cytochrome c level elevated along with increasing Apaf-1 and MCF7 cells were sensitised to Docetaxel, suggesting that loss of Apaf-1 may cause Docetaxel-resistance in breast cancer cells through less apoptosome formation. Docetaxel 183-192 apoptotic peptidase activating factor 1 Homo sapiens 166-172 33904968-8 2021 In Apaf-1 overexpressing, Docetaxel was more efficient in preventing cell migration, however, Docetaxel plus Bortezomib were not significantly effective; and fluorescence images supported the interpretation. Docetaxel 26-35 apoptotic peptidase activating factor 1 Homo sapiens 3-9 33904968-9 2021 Our findings demonstrated MCF7 resistance to Docetaxel is due in part to low Apaf-1 level and Apaf-1 overexpression resulted in the increase of cell susceptibility to Docetaxel stimulus. Docetaxel 45-54 apoptotic peptidase activating factor 1 Homo sapiens 77-83 33904968-9 2021 Our findings demonstrated MCF7 resistance to Docetaxel is due in part to low Apaf-1 level and Apaf-1 overexpression resulted in the increase of cell susceptibility to Docetaxel stimulus. Docetaxel 45-54 apoptotic peptidase activating factor 1 Homo sapiens 94-100 33904968-9 2021 Our findings demonstrated MCF7 resistance to Docetaxel is due in part to low Apaf-1 level and Apaf-1 overexpression resulted in the increase of cell susceptibility to Docetaxel stimulus. Docetaxel 167-176 apoptotic peptidase activating factor 1 Homo sapiens 94-100