PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 34386060-5 2021 Notably, restoration of the ATG5-dependent autophagy in DU145 cells significantly increased the cytotoxic effects of the chemotherapeutic drugs, docetaxel and valproic acid, and the endoplasmic reticulum stress inducers, brefeldin A, tunicamycin and thapsigargin. Docetaxel 145-154 autophagy related 5 Homo sapiens 28-32 32617902-9 2020 ROS inhibition by N-Acetyl Cysteine (NAC), as well as autophagy inhibition by ATG5 silencing significantly reduced the autophagy level as well as cytotoxicity of the DTX + DSF combination, indicating that the induction of autophagy mediated by high ROS generation played a critical role behind the synergistic cytotoxicity. Docetaxel 166-169 autophagy related 5 Homo sapiens 78-82