PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 32234375-0 2020 NPRL2 promotes docetaxel chemoresistance in castration resistant prostate cancer cells by regulating autophagy through the mTOR pathway. Docetaxel 15-24 NPR2 like, GATOR1 complex subunit Homo sapiens 0-5 32234375-6 2020 We found that NPRL2 was significantly overexpressed in docetaxel-resistant CRPC cells, while autophagy was enhanced and mTOR signaling was inhibited. Docetaxel 55-64 NPR2 like, GATOR1 complex subunit Homo sapiens 14-19 32234375-7 2020 Inhibiting NPRL2 increased the sensitivity to docetaxel in docetaxel-resistant CRPC cells, enhanced apoptosis and inhibited autophagy, and the opposite trends were observed when the mTOR inhibitor torin 1 was added to NPRL2-silenced cells. Docetaxel 46-55 NPR2 like, GATOR1 complex subunit Homo sapiens 11-16 32234375-7 2020 Inhibiting NPRL2 increased the sensitivity to docetaxel in docetaxel-resistant CRPC cells, enhanced apoptosis and inhibited autophagy, and the opposite trends were observed when the mTOR inhibitor torin 1 was added to NPRL2-silenced cells. Docetaxel 59-68 NPR2 like, GATOR1 complex subunit Homo sapiens 11-16 32234375-8 2020 We further found that NPRL2 silenced docetaxel-resistant CRPC cells were sensitive to docetaxel in vivo. Docetaxel 37-46 NPR2 like, GATOR1 complex subunit Homo sapiens 22-27 32234375-8 2020 We further found that NPRL2 silenced docetaxel-resistant CRPC cells were sensitive to docetaxel in vivo. Docetaxel 86-95 NPR2 like, GATOR1 complex subunit Homo sapiens 22-27