PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 18082731-2 2008 LPS-induced NO production and inducible NO synthase (iNOS) expression were significantly enhanced in the macrophages isolated from rats injected intraperitoneally with docetaxel (4 mg/kg body weight per day for 5 consecutive days) compared with those in macrophages from control rats administrated a vehicle. Docetaxel 168-177 nitric oxide synthase 2 Rattus norvegicus 30-51 18082731-2 2008 LPS-induced NO production and inducible NO synthase (iNOS) expression were significantly enhanced in the macrophages isolated from rats injected intraperitoneally with docetaxel (4 mg/kg body weight per day for 5 consecutive days) compared with those in macrophages from control rats administrated a vehicle. Docetaxel 168-177 nitric oxide synthase 2 Rattus norvegicus 53-57 18082731-4 2008 On the other hand, in vitro treatment of macrophages with docetaxel (5 and 10 microg/ml) inhibited LPS-induced NO production and iNOS expression. Docetaxel 58-67 nitric oxide synthase 2 Rattus norvegicus 129-133 18082731-6 2008 These results suggest that docetaxel has an enhancing action in vivo on LPS-induced iNOS expression and subsequent NO production through stimulation of p38 activity in alveolar macrophages. Docetaxel 27-36 nitric oxide synthase 2 Rattus norvegicus 84-88