PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 18606716-5 2008 Suppression of osteoclastogenesis through RANKL inhibition may enhance the effects of docetaxel on skeletal tumors. Docetaxel 86-95 tumor necrosis factor (ligand) superfamily, member 11 Mus musculus 42-47 19082914-10 2009 RANKL mRNA expression induced by 1,25-dihydroxyvitamin D(3) plus prostaglandin E(2) in osteoblasts was not affected by docetaxel even at 10(-6) M. Docetaxel at 10(-6) M, but not at 10(-8) M, inhibited pit-forming activity of osteoclasts cultured on dentine. Docetaxel 147-156 tumor necrosis factor (ligand) superfamily, member 11 Mus musculus 0-5 18606716-11 2008 RANKL inhibition may enhance docetaxel effects by increasing tumor cell apoptosis as evident by increased active caspase-3. Docetaxel 29-38 tumor necrosis factor (ligand) superfamily, member 11 Mus musculus 0-5 18606716-12 2008 These studies show that inhibition of RANKL provides an additive benefit to docetaxel treatment in a murine model of prostate cancer bone metastasis and supports clinical evaluation of this treatment option in patients. Docetaxel 76-85 tumor necrosis factor (ligand) superfamily, member 11 Mus musculus 38-43 18324676-0 2008 RANKL inhibition is an effective adjuvant for docetaxel in a prostate cancer bone metastases model. Docetaxel 46-55 tumor necrosis factor (ligand) superfamily, member 11 Mus musculus 0-5 18324676-6 2008 METHODS: The efficacy of inhibiting RANKL, using a recombinant soluble RANK extracellular domain fused with the immunoglobulin Fc domain (RANK-Fc), was tested as an adjuvant therapy with docetaxel for PCa bone metastasis in a murine intra-tibial model. Docetaxel 187-196 tumor necrosis factor (ligand) superfamily, member 11 Mus musculus 36-41