PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 32203934-0 2020 Regulation of docetaxel chemosensitivity by NR2F6 in breast cancer. Docetaxel 14-23 nuclear receptor subfamily 2 group F member 6 Homo sapiens 44-49 32203934-4 2020 Herein, both data mining and profiling analysis using clinical BCa biopsies showed that expression levels of the nuclear receptor subfamily 2, group F, member 6 (NR2F6), a recently characterized central transcription factor for cancer immune surveillance, were significantly downregulated in DTX-resistant BCa. Docetaxel 292-295 nuclear receptor subfamily 2 group F member 6 Homo sapiens 113-160 32203934-4 2020 Herein, both data mining and profiling analysis using clinical BCa biopsies showed that expression levels of the nuclear receptor subfamily 2, group F, member 6 (NR2F6), a recently characterized central transcription factor for cancer immune surveillance, were significantly downregulated in DTX-resistant BCa. Docetaxel 292-295 nuclear receptor subfamily 2 group F member 6 Homo sapiens 162-167 32203934-6 2020 In both genetically engineered cell models and patient-derived xenograft models, we provided evidence that BCa cells with insufficient NR2F6 expression were less responsive to DTX treatment. Docetaxel 176-179 nuclear receptor subfamily 2 group F member 6 Homo sapiens 135-140 32203934-8 2020 Stable PDGFRB inhibition ameliorated NR2F6 deficiency-impaired response to DTX in BCa cells, indicating that NR2F6"s effect on DTX response is mediated, at least in part, through transcriptional repression of PDGFRB. Docetaxel 75-78 nuclear receptor subfamily 2 group F member 6 Homo sapiens 37-42 32203934-8 2020 Stable PDGFRB inhibition ameliorated NR2F6 deficiency-impaired response to DTX in BCa cells, indicating that NR2F6"s effect on DTX response is mediated, at least in part, through transcriptional repression of PDGFRB. Docetaxel 75-78 nuclear receptor subfamily 2 group F member 6 Homo sapiens 109-114 32203934-8 2020 Stable PDGFRB inhibition ameliorated NR2F6 deficiency-impaired response to DTX in BCa cells, indicating that NR2F6"s effect on DTX response is mediated, at least in part, through transcriptional repression of PDGFRB. Docetaxel 127-130 nuclear receptor subfamily 2 group F member 6 Homo sapiens 37-42 32203934-8 2020 Stable PDGFRB inhibition ameliorated NR2F6 deficiency-impaired response to DTX in BCa cells, indicating that NR2F6"s effect on DTX response is mediated, at least in part, through transcriptional repression of PDGFRB. Docetaxel 127-130 nuclear receptor subfamily 2 group F member 6 Homo sapiens 109-114