PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
32512068-4	2020	TAMs in IBC secrete high levels of the cytokines interleukin-8 (IL-8) and monocyte chemoattractant protein-1 (MCP-1/CCL2) compared to non-IBC patients.	tams	0-4	C-C motif chemokine ligand 2	Homo sapiens	74-108	
33205453-8	2021	Furthermore, we found that, after treatment with S100A9, HepG2 and MHCC-97H cells recruited more macrophages via chemokine (C C motif) ligand 2, which suggests a positive feedback between TAMs and HCC cells.	tams	188-192	C-C motif chemokine ligand 2	Homo sapiens	113-143	
32512068-4	2020	TAMs in IBC secrete high levels of the cytokines interleukin-8 (IL-8) and monocyte chemoattractant protein-1 (MCP-1/CCL2) compared to non-IBC patients.	tams	0-4	C-C motif chemokine ligand 2	Homo sapiens	110-115	
32512068-4	2020	TAMs in IBC secrete high levels of the cytokines interleukin-8 (IL-8) and monocyte chemoattractant protein-1 (MCP-1/CCL2) compared to non-IBC patients.	tams	0-4	C-C motif chemokine ligand 2	Homo sapiens	116-120	
30165193-7	2018	Among these cytokines increased in conditioned media of co-cultured cells, CCL2 was secreted from TAMs, leading to induction of ERO1-alpha, MMP-9 upregulation, and invasiveness in MCF10A cells.	tams	98-102	C-C motif chemokine ligand 2	Homo sapiens	75-79	
32103760-11	2020	Animal studies show blockade of CCL2-CCR2 axis strongly reduces tumor incidence by hindering TAMs recruitment and thereby potentiates the antitumor efficacy of CD8+ T cells in the tumor microenvironment.	tams	93-97	C-C motif chemokine ligand 2	Homo sapiens	32-36	
32140070-8	2020	We first report the connection between Wnt5a/CaMKII/ERK/CCL2 axis and biological functions of TAMs in tumor microenvironment, indicating that Wnt5a may be a novel therapeutic target for CRC.	tams	94-98	C-C motif chemokine ligand 2	Homo sapiens	56-60	
31243299-6	2019	As a result, neddylation inactivation exhibits lower chemotaxis of monocytes, thereby decreasing TAMs infiltration, which can be alleviated by CCL2 addition.	tams	97-101	C-C motif chemokine ligand 2	Homo sapiens	143-147	
30927925-13	2019	CONCLUSIONS: Our data indicates that TAMs induce EMT program to enhance CRC migration, invasion, and CTC-mediated metastasis by regulating the JAK2/STAT3/miR-506-3p/FoxQ1 axis, which in turn leads to the production of CCL2 that promote macrophage recruitment, revealing a new cross-talk between immune cells and tumor cells in CRC microenvironment.	tams	37-41	C-C motif chemokine ligand 2	Homo sapiens	218-222	
32195015-5	2020	The formation and secretion of TAMs with M2 phenotypic characteristics, such as HIF-1alpha, and TNF-alpha, affect the progress of cancer cells by interfering with the secretion of MCP-1 by CAAs.	tams	31-35	C-C motif chemokine ligand 2	Homo sapiens	180-185	
11571719-8	2001	In addition, MCP-1 expression tended to be associated with the accumulation of TAMs, which were counted by CD68 staining, and with microvessel density.	tams	79-83	C-C motif chemokine ligand 2	Homo sapiens	13-18	
28039457-2	2017	We previously reported that TAMs promote prostate cancer metastasis via activation of the CCL2-CCR2 axis.	tams	28-32	C-C motif chemokine ligand 2	Homo sapiens	90-94	
29038174-7	2017	Mechanistically, ZEB1 expression in TAMs induced their polarization toward an F4/80low pro-tumor phenotype, including direct activation of Ccr2 In turn, expression of ZEB1 by TAMs induced Ccl2, Cd74, and a mesenchymal/stem-like phenotype in cancer cells.	tams	36-40	C-C motif chemokine ligand 2	Homo sapiens	188-192	
29038174-7	2017	Mechanistically, ZEB1 expression in TAMs induced their polarization toward an F4/80low pro-tumor phenotype, including direct activation of Ccr2 In turn, expression of ZEB1 by TAMs induced Ccl2, Cd74, and a mesenchymal/stem-like phenotype in cancer cells.	tams	175-179	C-C motif chemokine ligand 2	Homo sapiens	188-192	
11571719-9	2001	MCP-1 expression in TAMs was correlated significantly with the histologic vessel invasion of tumor cells.	tams	20-24	C-C motif chemokine ligand 2	Homo sapiens	0-5	
34178639-8	2021	The recruitment of TAMs and the secretion of CCL2 were dramatically reduced after LDHA was knocked down in vitro and in vivo.	tams	19-23	C-C motif chemokine ligand 2	Homo sapiens	45-49	
10209485-3	1998	To investigate the molecular mechanism leading to the TAM-rich stroma, the expression of a monocyte-specific chemotactic and activating factor, monocyte chemoattractant protein-1 (MCP-1), was studied by reverse transcriptase-polymerase chain reaction (RT-PCR) and in situ hybridization (ISH), and the presence of TAMs was demonstrated by immunohistochemistry in nine LELCs.	tams	313-317	C-C motif chemokine ligand 2	Homo sapiens	144-178	
10209485-3	1998	To investigate the molecular mechanism leading to the TAM-rich stroma, the expression of a monocyte-specific chemotactic and activating factor, monocyte chemoattractant protein-1 (MCP-1), was studied by reverse transcriptase-polymerase chain reaction (RT-PCR) and in situ hybridization (ISH), and the presence of TAMs was demonstrated by immunohistochemistry in nine LELCs.	tams	313-317	C-C motif chemokine ligand 2	Homo sapiens	180-185