PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 34586722-4 2021 In detail, LUAD cells secreted exosomes to transport miR-19b-3p into TAMs so that miR-19b-3p targeted PTPRD and inhibited the PTPRD-mediated dephosphorylation of STAT3 in TAMs, leading to STAT3 activation and M2 polarization. tams 69-73 signal transducer and activator of transcription 3 Homo sapiens 162-167 25572805-7 2015 The possible TAMs-modulated drug resistance mechanism involved may be associated with elevation of bcl-2 gene expression and up-regulation of STAT3 signaling in tumor cells. tams 13-17 signal transducer and activator of transcription 3 Homo sapiens 142-147 25572805-8 2015 Furthermore, the blockage of TAMs-derived IL-10 by neutralizing antibody resulted in attenuation of STAT3 activation and decrease of bcl-2 mRNA expression, consequently enhanced sensitivity of breast cancer cells. tams 29-33 signal transducer and activator of transcription 3 Homo sapiens 100-105 25572805-9 2015 Our data suggested that TAMs might induce drug resistance through IL-10/STAT3/bcl-2 signaling pathway, providing possible new targets for breast tumor therapy. tams 24-28 signal transducer and activator of transcription 3 Homo sapiens 72-77 28285690-4 2017 In the present study, we investigated the relationship of TAMs and SCLC cells to test the hypothesis that TAMs induce tumor progression in SCLC via STAT3 activation. tams 106-110 signal transducer and activator of transcription 3 Homo sapiens 148-153 28285690-12 2017 CONCLUSION: These results suggest that TAMs are likely involved in SCLC progression via STAT3 activation and TAM-derived IL-6 is indicated to be one of molecules related to STAT3 activation in SCLC cells. tams 39-43 signal transducer and activator of transcription 3 Homo sapiens 88-93 25370943-8 2015 Overall, these results suggest that the B7-H3-mediated STAT3 signaling pathway is an important mechanism for inducing M2-type polarization of TAMs, which accelerates HCC development. tams 142-146 signal transducer and activator of transcription 3 Homo sapiens 55-60 34061243-3 2022 Signal transducer and activator of transcription 3 (STAT3) is over-activated in human cancers, and specifically within TAMs activation of STAT3 may induce an immunosuppressive (M2-like) phenotype. tams 119-123 signal transducer and activator of transcription 3 Homo sapiens 0-50 34061243-3 2022 Signal transducer and activator of transcription 3 (STAT3) is over-activated in human cancers, and specifically within TAMs activation of STAT3 may induce an immunosuppressive (M2-like) phenotype. tams 119-123 signal transducer and activator of transcription 3 Homo sapiens 52-57 34061243-3 2022 Signal transducer and activator of transcription 3 (STAT3) is over-activated in human cancers, and specifically within TAMs activation of STAT3 may induce an immunosuppressive (M2-like) phenotype. tams 119-123 signal transducer and activator of transcription 3 Homo sapiens 138-143 34061243-6 2022 Specific increase in pSTAT3 levels within CD163pos cells supports that the CD163 scavenger receptor may be a useful target for future delivery of STAT3-inhibitory drugs to TAMs in MM patients. tams 172-176 signal transducer and activator of transcription 3 Homo sapiens 146-151 34586722-4 2021 In detail, LUAD cells secreted exosomes to transport miR-19b-3p into TAMs so that miR-19b-3p targeted PTPRD and inhibited the PTPRD-mediated dephosphorylation of STAT3 in TAMs, leading to STAT3 activation and M2 polarization. tams 69-73 signal transducer and activator of transcription 3 Homo sapiens 188-193 35188323-5 2022 The phosphorylation of STAT3 and the TLR4/TRAF6/TBK1 cascade reaction in TAMs were analyzed using western blotting, and mitochondrial ROS (mtROS) production was measured using a MitoSox kit. tams 73-77 signal transducer and activator of transcription 3 Homo sapiens 23-28 35188323-7 2022 RESULTS: ALDH3A1 attenuated STAT3 phosphorylation at Ser727 rapidly and mtROS production earlier in TAMs via inhibiting TLR4/TRAF6/TBK1 cascade reaction. tams 100-104 signal transducer and activator of transcription 3 Homo sapiens 28-33 30927925-13 2019 CONCLUSIONS: Our data indicates that TAMs induce EMT program to enhance CRC migration, invasion, and CTC-mediated metastasis by regulating the JAK2/STAT3/miR-506-3p/FoxQ1 axis, which in turn leads to the production of CCL2 that promote macrophage recruitment, revealing a new cross-talk between immune cells and tumor cells in CRC microenvironment. tams 37-41 signal transducer and activator of transcription 3 Homo sapiens 148-153 35186730-5 2022 The polarization of TAMs is mainly regulated by the pathways such as NFKB1 pathways, STAT3 pathways, WNT5A pathways, and PI3K pathways in CRC. tams 20-24 signal transducer and activator of transcription 3 Homo sapiens 85-90 35256947-4 2022 Mechanistically, we demonstrate that TGR5 promotes TAMs into protumorigenic M2-like phenotypes via activating cAMP-STAT3/STAT6 signaling. tams 51-55 signal transducer and activator of transcription 3 Homo sapiens 115-120 34991659-6 2022 Reciprocally, IL-6 produced by TNBC cells activated the JAK2/STAT3 axis to induce TGF-beta1 secretion by TAMs, thus constituted a feed-forward circuit. tams 105-109 signal transducer and activator of transcription 3 Homo sapiens 61-66 34991668-10 2022 Cellular signaling assays indicated the activation of Jak/Stat3 pathway in the OSCC cells treated by the CM from M1-like TAMs. tams 121-125 signal transducer and activator of transcription 3 Homo sapiens 58-63 34991668-11 2022 Blocking the activation of the Jak/Stat3 pathway could significantly weaken the effects of M1-like TAMs on the colony forming, invasion, migration, microsphere forming and xenograft forming abilities of OSCC cells. tams 99-103 signal transducer and activator of transcription 3 Homo sapiens 35-40 34991668-13 2022 Bioinformatics prediction and ChIP assays revealed the activation of Stat3 by CM from M1-like TAMs could directly promote the transcription of THBS1 in OSCC cells. tams 94-98 signal transducer and activator of transcription 3 Homo sapiens 69-74 34991668-14 2022 CONCLUSIONS: We proposed that M1-like TAMs could cascade a mesenchymal/stem-like phenotype of OSCC via the IL6/Stat3/THBS1 feedback loop. tams 38-42 signal transducer and activator of transcription 3 Homo sapiens 111-116 32228612-13 2020 CONCLUSIONS: Our data indicate that Wnt5a could induce M2 polarization of TAMs by regulating CaKMII-ERK1/2-STAT3 pathway-mediated IL-10 secretion, ultimately promoting tumor growth and metastasis of CRC. tams 74-78 signal transducer and activator of transcription 3 Homo sapiens 107-112 33716082-15 2021 Both of TAMs and IL-10 caused STAT3 activation and PD-L1 higher expression, the immunosuppressive molecules in TNBC cells, and this effect can be attenuated by IL-10 neutralizing antibody. tams 8-12 signal transducer and activator of transcription 3 Homo sapiens 30-35 33716082-16 2021 Dandelion extract exerted inhibition on STAT3 and PD-L1 in TNBC cells under TAMs microenvironment. tams 76-80 signal transducer and activator of transcription 3 Homo sapiens 40-45 33009518-5 2021 Then, CCL5 educated macrophages toward TAMs, which reciprocally enhanced ccRCC progression through CCL5/CCR5 and activated STAT3/SOX17low/YAP. tams 39-43 signal transducer and activator of transcription 3 Homo sapiens 123-128 32603665-10 2020 Moreover, the induction of IKBKE by TAMs in TNBC cells was identified to be associated with STAT3 signaling, which was activated by TAM-secreted IL-6 and IL-10. tams 36-40 signal transducer and activator of transcription 3 Homo sapiens 92-97 32653013-9 2020 TAMs enhanced CRC cell proliferation and invasion via IL-6, and then activated the IL-6R/STAT3 pathway in CRC cells. tams 0-4 signal transducer and activator of transcription 3 Homo sapiens 89-94 32653013-13 2020 CONCLUSIONS: CPEB3 is involved in the crosstalk between CRC cells and TAMs by targeting IL-6R/STAT3 signaling. tams 70-74 signal transducer and activator of transcription 3 Homo sapiens 94-99 32300100-9 2020 Taken together, TAMs/CCL5 could promote PCSCs self-renewal and prostate cancer metastasis via activating beta-catenin/STAT3 signaling. tams 16-20 signal transducer and activator of transcription 3 Homo sapiens 118-123 32278133-9 2020 Furthermore, IL-37 promoted TAMs polarization from M2 to M1 subtype through inhibiting the IL-6/STAT3 signaling. tams 28-32 signal transducer and activator of transcription 3 Homo sapiens 96-101 30637473-3 2019 Activation of the transcription factor STAT3 within the tumor microenvironment is associated with worse prognosis, and STAT3 activation promotes the immunosuppressive phenotype of TAMs. tams 180-184 signal transducer and activator of transcription 3 Homo sapiens 119-124 30343113-4 2019 In this study, we proved that TAMs possess the ability to promote OS cell migration and invasion by upregulating COX-2, MMP9, and phosphorylated STAT3 and to induce the epithelial-mesenchymal transition (EMT). tams 30-34 signal transducer and activator of transcription 3 Homo sapiens 145-150 30343113-7 2019 We propose that TAMs promote OS metastasis and invasion by activating the COX-2/STAT3 axis and EMT. tams 16-20 signal transducer and activator of transcription 3 Homo sapiens 80-85