PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
32787110-4	2020	The CSF1-CSF1R signaling pathway modulates the production, differentiation and function of TAMs; however, the discovery of selective CSF1R inhibitors devoid of Type III kinase activity has proven to be challenging.	tams	91-95	colony stimulating factor 1	Homo sapiens	4-8	
33545279-14	2021	This work is scientifically relevant as we demonstrate for the first time that local administration of a CSF-1Ri to the lungs leads to a shift in balance of TAMs in the TME of a model of lung tumor, adding to the sparse literature of CSF-1Ris related to lung cancers.	tams	157-161	colony stimulating factor 1	Homo sapiens	105-110	
30616794-4	2019	Several approaches to block TAMs have been investigated, including TAMs inactivation by means of the colony stimulating factor 1 (CSF-1)/CSF-1 receptor (CSF-1R) inhibitors or strategies to reprogram TAMs from M2 protumoral phenotype toward M1 antitumoral phenotype.	tams	67-71	colony stimulating factor 1	Homo sapiens	101-128	
30616794-4	2019	Several approaches to block TAMs have been investigated, including TAMs inactivation by means of the colony stimulating factor 1 (CSF-1)/CSF-1 receptor (CSF-1R) inhibitors or strategies to reprogram TAMs from M2 protumoral phenotype toward M1 antitumoral phenotype.	tams	67-71	colony stimulating factor 1	Homo sapiens	101-128	
29059867-5	2017	The extracellularly released BLZ-945 could be taken up by TAMs, which locate preferentially in the perivascular region [4], to directly disturb CSF-1/CSF-1R signaling pathway to suppress TAMs and modulate the tumor immune microenvironment, while the released small particles carrying Pt-prodrug could penetrate deeply into bulk tumor to kill more cancer cells [5], realizing synergistic antitumor effect of chemo- and immunotherapy (Fig.	tams	58-62	colony stimulating factor 1	Homo sapiens	144-149	
29875321-4	2018	This reduction in CSF1-dependent TAMs resulted in increased CD8+ T cell attack on tumors, but its effect on tumor growth was limited by a compensatory increase in Foxp3+ Treg cells.	tams	33-37	colony stimulating factor 1	Homo sapiens	18-22	
28101209-7	2016	Stratified analysis demonstrated that, in AIS/MIA patients, there was a statistically significant difference between the number of TAMs (TAMs <=25 and TAMs >25) in the CD68+CSF-1+IL-6+ group compared with other groups (including CD68+CSF-1-IL-6-, CD68+CSF-1+IL-6-, CD68+CSF-1-IL-6+ and CD68- groups).	tams	131-135	colony stimulating factor 1	Homo sapiens	179-184	
35366939-9	2022	TAb2 tumor cells drastically expanded F4/80+ TAMs from bone marrow precursors, requiring CSF1 and VEGF.	tams	45-49	colony stimulating factor 1	Homo sapiens	89-93	
34288020-14	2021	CONCLUSIONS: IL-1beta-induced SLC7A11 overexpression upregulated PD-L1 and CSF1 through alphaKG/HIF1alpha axis, which promoted TAMs and MDSCs infiltration.	tams	127-131	colony stimulating factor 1	Homo sapiens	75-79	
33805444-4	2021	Currently, inhibition of CSF-1/CSF-1R interaction by therapeutic antibody to deplete TAMs and their pro-tumor functions is becoming a prevalent strategy in cancer therapy.	tams	85-89	colony stimulating factor 1	Homo sapiens	25-30	
34969774-12	2021	This study further indicated that M-CSF secreted by OvCa cells drived the polarization of M2-TAMs.	tams	93-97	colony stimulating factor 1	Homo sapiens	34-39	
34969774-13	2021	Therefore, a CCL18-ZEB1-M-CSF interacting loop between OvCa cells and TAMs in the spheroids was identified.	tams	70-74	colony stimulating factor 1	Homo sapiens	24-29