PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 11259567-0 2001 Rebamipide suppresses formyl-methionyl-leucyl-phenylalanine (fMLP)-induced superoxide production by inhibiting fMLP-receptor binding in human neutrophils. rebamipide 0-10 formyl peptide receptor 1 Homo sapiens 61-65 11259567-0 2001 Rebamipide suppresses formyl-methionyl-leucyl-phenylalanine (fMLP)-induced superoxide production by inhibiting fMLP-receptor binding in human neutrophils. rebamipide 0-10 formyl peptide receptor 1 Homo sapiens 111-124 11259567-1 2001 The purpose of the present work was to investigate the mechanism underlying the inhibitory action of rebamipide on superoxide anion (O2) production induced by the chemotactic peptide formyl-methionyl-leucyl-phenylalanine (fMLP) in human neutrophils. rebamipide 101-111 formyl peptide receptor 1 Homo sapiens 222-226 11259567-3 2001 Rebamipide inhibited PIP(3) production in parallel with the inhibition of fMLP-induced O2 production. rebamipide 0-10 formyl peptide receptor 1 Homo sapiens 74-78 11259567-6 2001 Scatchard analysis of [3H]fMLP binding to human neutrophil membrane revealed that rebamipide increased the K(D) value of [3H]fMLP without altering the number of [3H]fMLP binding sites, suggesting that rebamipide has a competitive antagonistic action against the fMLP-receptor. rebamipide 82-92 formyl peptide receptor 1 Homo sapiens 26-30 11259567-6 2001 Scatchard analysis of [3H]fMLP binding to human neutrophil membrane revealed that rebamipide increased the K(D) value of [3H]fMLP without altering the number of [3H]fMLP binding sites, suggesting that rebamipide has a competitive antagonistic action against the fMLP-receptor. rebamipide 82-92 formyl peptide receptor 1 Homo sapiens 125-129 11259567-6 2001 Scatchard analysis of [3H]fMLP binding to human neutrophil membrane revealed that rebamipide increased the K(D) value of [3H]fMLP without altering the number of [3H]fMLP binding sites, suggesting that rebamipide has a competitive antagonistic action against the fMLP-receptor. rebamipide 82-92 formyl peptide receptor 1 Homo sapiens 125-129 11259567-6 2001 Scatchard analysis of [3H]fMLP binding to human neutrophil membrane revealed that rebamipide increased the K(D) value of [3H]fMLP without altering the number of [3H]fMLP binding sites, suggesting that rebamipide has a competitive antagonistic action against the fMLP-receptor. rebamipide 82-92 formyl peptide receptor 1 Homo sapiens 262-275 11259567-7 2001 The competitive antagonistic action was further confirmed by the finding that rebamipide caused a parallel shift to the right in the dose-response curve of O2 production induced by fMLP. rebamipide 78-88 formyl peptide receptor 1 Homo sapiens 181-185 11259567-8 2001 These results provide evidence that the competitive inhibitory action of rebamipide on the fMLP-receptor plays a main role in its inhibitory action on fMLP-induced O2 production. rebamipide 73-83 formyl peptide receptor 1 Homo sapiens 91-104 11259567-8 2001 These results provide evidence that the competitive inhibitory action of rebamipide on the fMLP-receptor plays a main role in its inhibitory action on fMLP-induced O2 production. rebamipide 73-83 formyl peptide receptor 1 Homo sapiens 91-95