PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 27725198-0 2016 Differential effect of rebamipide on transmembrane mucin biosynthesis in stratified ocular surface epithelial cells. rebamipide 23-33 LOC100508689 Homo sapiens 51-56 33232357-0 2020 Assessment of mucin-related gene alterations following treatment with rebamipide ophthalmic suspension in Sjogren"s syndrome-associated dry eyes. rebamipide 70-80 LOC100508689 Homo sapiens 14-19 33232357-3 2020 In addition, we investigated alterations in mucin-related gene expression secondary to treatment with rebamipide ophthalmic suspension in patients with Sjogren"s syndrome-associated dry eyes (SS-DE). rebamipide 102-112 LOC100508689 Homo sapiens 44-49 28587435-1 2017 It has been demonstrated that topical administration of rebamipide, which is an antiulcer agent, increases the mucin level of the tear film and ameliorates ocular surface conditions such as lid wiper epitheliopathy. rebamipide 56-66 LOC100508689 Homo sapiens 111-116 22335446-10 2012 CONCLUSIONS: Rebamipide promoted glycoconjugate, which has a property as a mucin-like glycoprotein, in human corneal epithelial cells. rebamipide 13-23 LOC100508689 Homo sapiens 75-80 22969286-3 2012 The therapeutic effects of rebamipide eye drops are due to its ability to increase corneal and conjunctival mucin-like substances and improve corneal and conjunctival injury in vivo. rebamipide 27-37 LOC100508689 Homo sapiens 108-113 18975081-6 2009 Total gastric mucin output was significantly increased by 53% by rebamipide administration from 3.2 +/- 1.2 mg hexose/10 min to 4.9 +/- 2.2 mg hexose/10 min (P < 0.01). rebamipide 65-75 LOC100508689 Homo sapiens 14-19 18975081-7 2009 Further analysis by ion-exchange chromatography revealed that rebamipide administration induced a specific increase in acidic mucin rich in sialic acid. rebamipide 62-72 LOC100508689 Homo sapiens 126-131 35184054-10 2022 Adding either exogenous mucin or the mucin secretagogue, rebamipide, partially alleviated the PSL-induced dysbiosis of the gut microbiota. rebamipide 57-67 LOC100508689 Homo sapiens 37-42 28983630-3 2017 The present study investigated whether rebamipide (Reb) acts as a secretagogue of intestinal mucin and the underlying mechanisms involved, thereby focusing on the effect on goblet cells. rebamipide 39-49 LOC100508689 Homo sapiens 93-98 28458352-7 2017 The administration of this ultrafine rebamipide suspension (2%) increased the conjunctival mucin, which was comparable to the commercially available micro-particle suspension (2%). rebamipide 37-47 LOC100508689 Homo sapiens 91-96 27257394-1 2016 OBJECTIVE: Rebamipide ophthalmic suspension was developed for the treatment of dry eyes and for other corneal diseases, promoting the secretion of both mucin in tear fluid and membrane-associated mucin, increasing the number of goblet cells, and restoring the barrier function of the corneal epithelium. rebamipide 11-21 LOC100508689 Homo sapiens 152-157 27257394-1 2016 OBJECTIVE: Rebamipide ophthalmic suspension was developed for the treatment of dry eyes and for other corneal diseases, promoting the secretion of both mucin in tear fluid and membrane-associated mucin, increasing the number of goblet cells, and restoring the barrier function of the corneal epithelium. rebamipide 11-21 LOC100508689 Homo sapiens 196-201 24204116-1 2013 Administration of topical rebamipide increases the mucin level of tear film and improves the ocular surface in short break-up time type of dry eye. rebamipide 26-36 LOC100508689 Homo sapiens 51-56 25574215-1 2015 The topical administration of rebamipide (Mucosta ), an antiulcer agent, clinically increases the mucin level of tear film. rebamipide 30-40 LOC100508689 Homo sapiens 98-103 25574215-7 2015 By contrast, the secondary resected specimen obtained three months after the initiation of topical rebamipide treatment revealed the epithelium and nevus, where numerous goblet cells were present (28 cells/HPF), and mucin-like substances were markedly secreted from the goblet cells. rebamipide 99-109 LOC100508689 Homo sapiens 216-221 24940041-3 2014 Investigations have confirmed that rebamipide increases corneal and conjunctival mucin-like substances along with improving corneal and conjunctival injury. rebamipide 35-45 LOC100508689 Homo sapiens 81-86 24940041-4 2014 Clinically, rebamipide ophthalmic suspensions can effectively treat tear deficiency and mucin-caused corneal epithelial damage, and can restore the microstructure responsible for tear stability. rebamipide 12-22 LOC100508689 Homo sapiens 88-93 23662915-3 2013 The eyedrop form of rebamipide, approved in Japan for use in the treatment of dry eye diseases, upregulates mucin secretion and production, thereby suppressing superficial punctate keratopathy on the ocular surface of patients with this disease. rebamipide 20-30 LOC100508689 Homo sapiens 108-113 27194990-5 2016 Subjective symptoms and expression levels of ocular surface mucin improved after combined treatment of rebamipide (4 times daily) and fluorometholone (once daily) ophthalmic suspension. rebamipide 103-113 LOC100508689 Homo sapiens 60-65 27194990-8 2016 Subjective symptoms and expression levels of ocular surface mucin improved by combined treatment of rebamipide (4 times daily) and fluorometholone (once daily) ophthalmic suspension. rebamipide 100-110 LOC100508689 Homo sapiens 60-65