PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
34691057-7	2021	Moreover, pathogens seem also to enhance Treg functions as shown in human immunodeficiency virus infection, where Tregs express higher levels of effector molecules such as cytotoxic T-lymphocyte-associated protein 4, CD39 and cAMP and show increased suppressive capacity.	tregs	114-119	cytotoxic T-lymphocyte associated protein 4	Homo sapiens	172-215	
34384744-7	2021	Both immune checkpoint deficiencies are biologically characterized by low levels of CTLA-4 protein on the cell surface of Tregs, accounting for the autoimmune manifestations observed in CTLA4-insufficient and LRBA-deficient patients.	tregs	122-127	cytotoxic T-lymphocyte associated protein 4	Homo sapiens	84-90	
34592958-8	2021	RESULTS: The frequency of Tregs was higher in chronic patients than in healthy controls (P = 0.026) and acute patients (P = 0.042); The frequency of CTLA-4+ Tregs in chronic patients was significantly higher than that in healthy controls (P = 0.011).	tregs	26-31	cytotoxic T-lymphocyte associated protein 4	Homo sapiens	149-155	
34592958-13	2021	CTLA-4 and TGF-beta1 may contribute to Tregs-mediated immunosuppression in the chronic infection stage of a Brucella infection.	tregs	39-44	cytotoxic T-lymphocyte associated protein 4	Homo sapiens	0-6	
34384744-7	2021	Both immune checkpoint deficiencies are biologically characterized by low levels of CTLA-4 protein on the cell surface of Tregs, accounting for the autoimmune manifestations observed in CTLA4-insufficient and LRBA-deficient patients.	tregs	122-127	cytotoxic T-lymphocyte associated protein 4	Homo sapiens	186-191	
35523809-7	2022	B7x-mediated regulation of Tregs reduces the efficacy of anti-CTLA-4 treatment, a therapeutic that partially relies on Treg-depletion.	tregs	27-32	cytotoxic T-lymphocyte associated protein 4	Homo sapiens	62-68	
34073458-3	2021	We show that, while CD4 CTL are resistant to suppression by Tregs in vitro, the conditioned medium of CD4 CTL accentuates the suppressive phenotype of Tregs by upregulating IL-10, Granzyme B, CTLA-4, and PD-1.	tregs	60-65	cytotoxic T-lymphocyte associated protein 4	Homo sapiens	192-198	
34073458-3	2021	We show that, while CD4 CTL are resistant to suppression by Tregs in vitro, the conditioned medium of CD4 CTL accentuates the suppressive phenotype of Tregs by upregulating IL-10, Granzyme B, CTLA-4, and PD-1.	tregs	151-156	cytotoxic T-lymphocyte associated protein 4	Homo sapiens	192-198	
33490159-15	2020	Furthermore, tumor necrosis factor (TNF), through interaction with TNFR2, enhanced the suppressive capacity of Tregs by up-regulating CTLA-4 and PD-L1 expression.	tregs	111-116	cytotoxic T-lymphocyte associated protein 4	Homo sapiens	134-140	
35326731-5	2022	Although activating T-cells is regarded as the primary anti-tumor mechanism of anti-CTLA-4 therapies, mounting evidence in the literature suggests targeting intra-tumoral Tregs as the primary mechanism of action of these agents.	tregs	171-176	cytotoxic T-lymphocyte associated protein 4	Homo sapiens	84-90	
35326731-7	2022	Anti-CTLA-4 therapy can enhance the priming of T-cells by blockading CD80/86-CTLA-4 interactions or depleting Tregs through antibody-dependent cellular cytotoxicity and phagocytosis.	tregs	110-115	cytotoxic T-lymphocyte associated protein 4	Homo sapiens	5-11	
33986285-7	2021	Ex vivo expansion of Tregs from patients with PD restored and enhanced their suppressive functions while expanded Tregs displayed increased expression of foxp3, il2ra (CD25), nt5e (CD73), il10, il13, ctla4, pdcd1 (PD1), and gzmb.	tregs	114-119	cytotoxic T-lymphocyte associated protein 4	Homo sapiens	200-205	
30415745-11	2018	Indeed, Tregs generated in the presence of hAECs expressed higher levels of CTLA-4 compared to Tregs generated in their absence and restrained the proliferation of autologus PBMCs in MLR system.	tregs	8-13	cytotoxic T-lymphocyte associated protein 4	Homo sapiens	76-82	
32840510-5	2020	Further results revealed that the synergistic immune stimulatory effects of CTLA-4 and PD-1 blockades in the form of hSNPs were at least partly through regulating the immune suppressive function of both Tregs and TIM3+ exhausted-like CD8 T cells and allowing effector T cells to expand.	tregs	203-208	cytotoxic T-lymphocyte associated protein 4	Homo sapiens	76-82	
32351508-5	2020	Administration of CTLA-4 monoclonal antibodies (mAbs) strongly enhanced IL36-stimulated antitumor activities through depletion of Tregs.	tregs	130-135	cytotoxic T-lymphocyte associated protein 4	Homo sapiens	18-24	
32621335-0	2020	CTLA-4 and HLA-DQ are key molecules in the regulation of mDC-mediated cellular immunity by Tregs in severe aplastic anemia.	tregs	91-96	cytotoxic T-lymphocyte associated protein 4	Homo sapiens	0-6	
29367462-3	2018	Based on high expression of CD5, we identified a subset of self-reactive Tregs expressing elevated levels of T-bet, GITR, CTLA-4, and ICOS, which imparted significant protection from autoimmune diabetes.	tregs	73-78	cytotoxic T-lymphocyte associated protein 4	Homo sapiens	122-128