PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 33830475-0 2021 IL-2/IL-2R Antibody Complex Enhances Treg-Induced Neuroprotection by Dampening TNF-alpha Inflammation in an In Vitro Stroke Model. treg 37-41 tumor necrosis factor Homo sapiens 79-88 33830475-8 2021 Moreover, the inflammatory marker, TNF-alpha, was upregulated after OGD/R, dampened by both Tregs and more efficiently by IL-2/IL-2R-treated Tregs but more pronounced in the latter, and not affected by IL-2/IL-2R treatment alone, suggesting IL-2/IL-2R-Treg-mediated modulation of inflammatory response in stroke. treg 92-96 tumor necrosis factor Homo sapiens 35-44 31262519-5 2019 TGF-betasRII, a blocker of transforming growth factor-beta (TGF-beta), can attenuate the effects of Treg elevation, suggesting that TGF-beta is the main cytokine, while Breg cells rather than interleukin-10 (IL-10) regulate the differentiation of Treg cells. treg 100-104 tumor necrosis factor Homo sapiens 27-58 33532902-8 2021 Moreover, we focus on metabolic reprogramming of Tregs that could unveil potential regulatory networks favoring tumorigenesis/progression, and provide novel insights, including inhibitors against acetyl-coA carboxylase 1 and transforming growth factor beta into targeting Treg metabolism for therapeutic benefits. treg 49-53 tumor necrosis factor Homo sapiens 225-256 33000506-3 2020 In this study, we explored whether TNF-alpha-mediated inflammation upregulates MHC-II on AT-II cells to trigger Treg expansion in inflammation-driven lung adenocarcinoma (IDLA). treg 112-116 tumor necrosis factor Homo sapiens 35-44 33000506-10 2020 Thus, tumor cells of AT-II cellular origin contribute to Treg expansion in an MHC-II-dependent manner in TNF-alpha-mediated IDLA. treg 57-61 tumor necrosis factor Homo sapiens 105-114 29861472-5 2018 We have recently reported that Treg-induced Foxp3 binds the interleukin-2 (IL-2), interferon-gamma (IFN- gamma), and tumor necrosis factor-alpha (TNF-alpha) promoters in virus-specific CD8+ T cells. treg 31-35 tumor necrosis factor Homo sapiens 117-144 29861472-5 2018 We have recently reported that Treg-induced Foxp3 binds the interleukin-2 (IL-2), interferon-gamma (IFN- gamma), and tumor necrosis factor-alpha (TNF-alpha) promoters in virus-specific CD8+ T cells. treg 31-35 tumor necrosis factor Homo sapiens 146-155 22159472-5 2012 Prior to surgery, the patients demonstrated Treg-mediated suppression of TNFalpha and IFNgamma expression that could be perturbed through the PGE(2)/cAMP pathway and the immune suppression was significantly higher in the group that later developed disease recurrence (P = 0.046). treg 44-48 tumor necrosis factor Homo sapiens 73-81 20339032-5 2010 Inhibition of PKC-theta protected Treg from inactivation by TNF-alpha, restored activity of defective Treg from rheumatoid arthritis patients, and enhanced protection of mice from inflammatory colitis. treg 34-38 tumor necrosis factor Homo sapiens 60-69 21555530-6 2011 Furthermore, we show that physiologically produced NO from TNF and inducible NO synthase-producing dendritic cells can contribute to Th1 development predominating over Treg development through a synergistic activity induced when these cells cocluster with conventional dendritic cells presenting Ag to naive Th cells. treg 168-172 tumor necrosis factor Homo sapiens 59-62 35623290-7 2022 Here, we summarize and discuss the latest progress in the studies on the downstream signaling pathways of TNF-TNFR2 for controlling Treg homeostasis, differentiation and proliferation. treg 132-136 tumor necrosis factor Homo sapiens 106-109 34452547-15 2021 CONCLUSION: TNFalpha has a positive correlation with M2 and Treg distribution,but mostly through a different mechanism other than EBER-TLR3 interaction. treg 60-64 tumor necrosis factor Homo sapiens 12-20 17654744-7 2007 Neutralization of IL-10 and TGF-beta or exogenous IL-1beta had no effect on Treg-mediated suppression of the anti-HBcAg response, whereas exogenous TNF-alpha partially abrogated Treg-mediated suppression. treg 178-182 tumor necrosis factor Homo sapiens 148-157 34471865-3 2021 Patients with PsA had an increased Th17:Treg ratio which was reversed by anti-tumor necrosis factor (TNF) therapy. treg 40-44 tumor necrosis factor Homo sapiens 78-99 34471865-3 2021 Patients with PsA had an increased Th17:Treg ratio which was reversed by anti-tumor necrosis factor (TNF) therapy. treg 40-44 tumor necrosis factor Homo sapiens 101-104 34471865-5 2021 In contrast, Treg from patients with PsA treated with anti-TNF suppressed CCL20-driven effector T-cell migration. treg 13-17 tumor necrosis factor Homo sapiens 59-62 34471865-6 2021 The boosting effect of TNF blockade upon Treg suppression of migration was accompanied by increased effector T-cell CCL20 production and enhanced interaction between Treg and effector T cells. treg 41-45 tumor necrosis factor Homo sapiens 23-26 34471865-6 2021 The boosting effect of TNF blockade upon Treg suppression of migration was accompanied by increased effector T-cell CCL20 production and enhanced interaction between Treg and effector T cells. treg 166-170 tumor necrosis factor Homo sapiens 23-26 34193955-7 2021 Additionally, we identify transforming growth factor beta (TGFbeta) as an essential factor for Treg induction secreted by MAPC cells. treg 95-99 tumor necrosis factor Homo sapiens 26-57 35584681-4 2022 Disease-imprinted macrophages express increased IL-1beta and are predicted to elicit altered TNF superfamily interactions with cutaneous Treg, and we demonstrate the direct loss of T cell regulation within the resolved skin. treg 137-141 tumor necrosis factor Homo sapiens 93-96