PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 23080082-6 2013 The ratio of CD4+Foxp3- and CD4+Foxp3+ fractions within the proliferating CD4+ pool progressively changed from 74:26 in control animals to 59:41 eleven days after irradiation, demonstrating a more dynamic increase in the proliferation and regeneration of the Treg pool. treg 259-263 CD4 antigen Mus musculus 13-16 25278453-0 2014 iNOS expression in CD4+ T cells limits Treg induction by repressing TGFbeta1: combined iNOS inhibition and Treg depletion unmask endogenous antitumor immunity. treg 39-43 CD4 antigen Mus musculus 19-22 23169344-9 2012 Both CD4(+) and CD8(+) T cells were involved in the anti-neuroblastoma responses induced by YB-1 immunization combined with Treg depletion. treg 124-128 CD4 antigen Mus musculus 5-8 23029447-2 2012 Previous work showed that IL-12 reversed Treg-mediated suppression of CD4(+)Foxp3(-) T cell (Tconv) proliferation. treg 41-45 CD4 antigen Mus musculus 70-73 34731632-2 2021 Here we show that cell-permeable alpha-ketoglutarate (alphaKG) alters the DNA methylation profile of naive CD4 T cells activated under Treg polarizing conditions, markedly attenuating FoxP3+ Treg differentiation and increasing inflammatory cytokines. treg 135-139 CD4 antigen Mus musculus 107-110 21697460-6 2011 Adoptively transferred CD4(+)CD25(-) T cells were converted into Treg within the liver after BDL. treg 65-69 CD4 antigen Mus musculus 23-26 20884652-4 2011 In contrast, CD4 T cell expansion and reactivity were suppressed significantly in injured Treg-replete mice. treg 90-94 CD4 antigen Mus musculus 13-16 20869773-3 2010 Here we show that, although purified naive cells are highly susceptible to Treg generation, total CD4(+) T-cell populations from different mouse strains display significantly different sensitivities to TGF-beta/ATRA-induced Treg conversion. treg 224-228 CD4 antigen Mus musculus 98-101 15788479-5 2005 Treg injection induced a dramatic decrease of glomerular damage as well as a marked decrease of CD4+ T cell, CD8+ T cell, and macrophage infiltration. treg 0-4 CD4 antigen Mus musculus 96-99 34932195-0 2022 Platelets differentially modulate CD4+ Treg activation via GPIIa/IIIb-, fibrinogen-, and PAR4-dependent pathways. treg 39-43 CD4 antigen Mus musculus 34-37 34932195-3 2022 We hypothesized that platelet activation mechanisms via GPIIb/IIIa, fibrinogen, and PAR4 have an immunological effect and modulate CD4+ Treg activation early after trauma. treg 136-140 CD4 antigen Mus musculus 131-134 34910890-6 2022 In conclusion, sRAGE can serve as a novel immunometabolic modulator that ameliorates ischemic stroke recovery by inhibiting fatty acid synthesis and thus favoring CD4+ T cells polarization toward Treg after cerebral ischemia injury. treg 196-200 CD4 antigen Mus musculus 163-166 34583939-5 2021 Repeated weekly cycles of IL-2 mutein doses (day 0) followed by ASI (day 3) resulted in a 3- to 5-fold enrichment in Treg among Ag-responsive CD4 T cells. treg 117-121 CD4 antigen Mus musculus 142-145 34583939-7 2021 Combining Treg enrichment with ASI has the potential to durably treat autoimmune disease or allergy by increasing the Treg/conventional CD4 T cell ratio among autoantigen- or allergen-specific T cells. treg 10-14 CD4 antigen Mus musculus 136-139 21949026-7 2011 Finally, Treg depletion in C57BL/6 transgenic APPPS1 mice, a mouse model of AD, results in enhanced vaccine-induced CD4(+) T cell responses in AD compared with wild-type animals. treg 9-13 CD4 antigen Mus musculus 116-119 19068204-5 2008 RESULTS: In vivo, the mean survival time of recipients with islets and antigen-specific CD4(+)CD25(+) Treg cells were (34.57+/-17.15) days, whereas transplanted islets without Treg treatment survived (10.6+/-1.82) days in control mice. treg 102-106 CD4 antigen Mus musculus 88-91 17256743-11 2007 Finally, cellular immune therapy with CD4+CD25+ cells prevented ConA-induced liver injury, with higher protection by Treg from ConA-tolerized mice. treg 117-121 CD4 antigen Mus musculus 38-41 34363211-7 2021 Expression of a constitutively activated form of Akt2 in CD4 T cells was sufficient to increase glycolysis in Tregs and drive changes in Treg subsets. treg 137-141 CD4 antigen Mus musculus 57-60 34816649-13 2021 Conclusion: Activating alpha1-AR on CD4+T cells of CIA mice enhances Treg cell function,facilitating a shift of CD4+T cells toward Treg polarization. treg 131-135 CD4 antigen Mus musculus 36-39 34816649-13 2021 Conclusion: Activating alpha1-AR on CD4+T cells of CIA mice enhances Treg cell function,facilitating a shift of CD4+T cells toward Treg polarization. treg 131-135 CD4 antigen Mus musculus 112-115 34132158-8 2021 Furthermore, in an adoptive transfer model, Treg-specific GnRHR knockdown increased Foxp3 expression in decidual Tregs while decreasing the production of IFN-gamma and IL-17 in decidual effector CD4+ T cells and reducing the production of IFN-gamma in decidual effector CD8+ T cells. treg 44-48 CD4 antigen Mus musculus 195-198 35550500-0 2022 Tim-3+ decidual Mphis induced Th2 and Treg bias in decidual CD4+T cells and promoted pregnancy maintenance via CD132. treg 38-42 CD4 antigen Mus musculus 60-63 35216600-8 2022 Additionally, the combination treatment upregulated Treg-related genes-Nt5e, Foxp3, Ikzf2, Nrp1 and Itgb8-in murine CD4+-T cells. treg 52-56 CD4 antigen Mus musculus 116-119 35401514-8 2022 We found that in wild-type mice, CD4+ Tregs exhibit a significant upregulation of VISTA which correlates with higher Treg abundance in the spleen and small intestine following septic insult. treg 117-121 CD4 antigen Mus musculus 33-36 35563702-5 2022 Specifically, the homeostasis of CD4+CD25+Foxp3+ but not the CD4+CD25-Foxp3+ fraction is severely perturbed when NFAT signaling is blocked, leading to a strongly reduced Treg population. treg 170-174 CD4 antigen Mus musculus 33-36 32976550-6 2021 In vitro, inducible Treg differentiation from naive CD4+ T cells was enhanced by IRX4204; in vivo, IRX4204 increased the conversion of donor Foxp3- T cells into peripheral Foxp3+ Tregs in GVHD mice. treg 20-24 CD4 antigen Mus musculus 52-55 32536579-12 2020 Mice overexpressing Id1 in CD4+ T cells possessed significantly higher Treg levels in spleen and lower autoantibody concentrations in serum. treg 71-75 CD4 antigen Mus musculus 27-30 33539546-9 2021 Exposure of primed CD4+ T cells to CD83/OVA-carrying exosomes promoted antigen-specific Treg generation. treg 88-92 CD4 antigen Mus musculus 19-22 32948683-7 2020 PD-1 and CTLA-4 were upregulated on tumor-infiltrating CD4+ and CD8+ T cells in irradiated and nonirradiated tumors, suggesting that immune checkpoint inhibitors could be beneficial after LRT and Foxp3+ Treg depletion. treg 203-207 CD4 antigen Mus musculus 55-58 32562271-8 2020 Heparin promoted functional CD4+ CD25+ forkhead box protein 3 (FoxP3)+ Treg generation from naive CD4+ T cells, increased interleukin (IL)-2 production and enhanced the activation of pre-existing Tregs with IL-2. treg 71-75 CD4 antigen Mus musculus 98-101 33013877-6 2020 Further Treg-enrichment (~80%) of the AgX population indicated FoxP3+CD25hiCD4+ Treg played a key role in EAU-suppression while FoxP3-CD25lo/-CD4+ T cells did not. treg 8-12 CD4 antigen Mus musculus 75-78 33378664-8 2020 Collectively, our study identifies CD4+ T cell KLF10 as an essential regulator of obesity and insulin resistance by altering Treg metabolism and mobilization. treg 125-129 CD4 antigen Mus musculus 35-38 32240221-8 2020 Extensive analysis of chemokine expression in gonadal fat and adipose CD4+CD25+T cells revealed several chemokine signals related to female-specific VAT-Treg accumulation such as CCL24, CCR6, and CXCR3. treg 153-157 CD4 antigen Mus musculus 70-73 32499651-3 2020 Here, using shared synteny to guide loss-of-function analysis of homologues of human enhancers in mice, we show that the prominent autoimmune and allergic disease risk locus at chromosome 11q13.52-7 contains a distal enhancer that is functional in CD4+ regulatory T (Treg) cells and required for Treg-mediated suppression of colitis. treg 267-271 CD4 antigen Mus musculus 248-251 31039339-6 2019 Insulin-specific CD4+ cell expansion peaked after 48 h of incubation and was in favour of Treg. treg 90-94 CD4 antigen Mus musculus 17-20 31653839-3 2019 Here, we compare immune repertoires of Treg-deficient and Treg-sufficient mice to find Tregs continuously constraining one-third of mature CD4+Foxp3- cells from converting to pathogenic effectors in healthy mice. treg 39-43 CD4 antigen Mus musculus 139-142 31288845-12 2019 Importantly, both the CD4+CD25-Foxp3+ T cells and the CD4+CD25+Foxp3+ Tregs in mice receiving SM16 diet exhibited diminished ability to suppress naive T cell proliferation in vitro compared to Treg from mice on control diet. treg 70-74 CD4 antigen Mus musculus 54-57 30612787-8 2019 Splenic CD4+ T cell expansion under same conditions resulted in a higher (44-45%) iTreg cell ratio that further increased (up to 50% Treg) in the presence of DX. treg 83-87 CD4 antigen Mus musculus 8-11 28539382-2 2017 We previously found that IL-2, which is critical for Treg homeostasis, upregulates the IL-33 receptor (ST2) on CD4+ T cells, thus we hypothesized that IL-2 and IL-33 cooperate to enhance Treg function. treg 187-191 CD4 antigen Mus musculus 111-114 28652399-7 2017 Thus, we propose that CD4+GITR+CD122+CD25-Foxp3- cells represent a Treg pre-precursor population, whose transition into Treg precursors is mediated via c-REL. treg 67-71 CD4 antigen Mus musculus 22-25 27564970-17 2016 The same results were found when CD4 + CD25- T-cells were co-cultured with Treg in the NS group. treg 75-79 CD4 antigen Mus musculus 33-36