PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
30021159-2	2018	OX40 signaling is known to inhibit Foxp3 expression and Treg induction, but the underlying mechanisms remain poorly defined.	treg	56-60	TNF receptor superfamily member 4	Homo sapiens	0-4	
34709423-10	2022	However, effector CD4+ T cells from slow progressors were more responsive to Treg suppression compared with healthy donors, demonstrated by increased suppression of CD25 and CD134 expression on effector CD4+ T cells.	treg	77-81	TNF receptor superfamily member 4	Homo sapiens	174-179	
29578532-0	2019	Critical role of OX40 signaling in the TCR-independent phase of human and murine thymic Treg generation.	treg	88-92	TNF receptor superfamily member 4	Homo sapiens	17-21	
33799782-8	2021	Moreover, higher TNFRSF4 expression was associated with greater survival, suggesting that TNFRSF4 could play a key role in mechanisms underlying the contribution of Treg in HNSCC outcomes.	treg	165-169	TNF receptor superfamily member 4	Homo sapiens	17-24	
33799782-8	2021	Moreover, higher TNFRSF4 expression was associated with greater survival, suggesting that TNFRSF4 could play a key role in mechanisms underlying the contribution of Treg in HNSCC outcomes.	treg	165-169	TNF receptor superfamily member 4	Homo sapiens	90-97	
33841630-4	2021	Activation of the OX40 signaling pathway can enhance the activity of CD4+/CD8+ T cells and inhibit the function of Treg.	treg	115-119	TNF receptor superfamily member 4	Homo sapiens	18-22	
33841630-5	2021	Simultaneously, OX40 can directly inhibit the expression of Foxp3, affect the inhibitory function of Treg, and inhibit the immunosuppressive factors in the tumor microenvironment so as to reverse immune escape and reverse drug resistance.	treg	101-105	TNF receptor superfamily member 4	Homo sapiens	16-20	
30021159-6	2018	Taken together, our results provide key mechanistic insights into how OX40 inhibits Foxp3 expression and Treg induction in the periphery.	treg	105-109	TNF receptor superfamily member 4	Homo sapiens	70-74