PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
32999002-5	2020	ICOS expression was higher on intratumoral TReg than on effector CD8 T cells.	treg	43-47	inducible T cell costimulator	Homo sapiens	0-4	
32726458-2	2020	When activated, ICOS signaling promotes FOXP3 CNS2 gene demethylation and stabilizes Treg differentiation.	treg	85-89	inducible T cell costimulator	Homo sapiens	16-20	
32726458-11	2020	Overall, these results demonstrated that ICOS signaling could significantly improve FOXP3 expression and enhance Treg functional potency.	treg	113-117	inducible T cell costimulator	Homo sapiens	41-45	
31143518-5	2019	Indeed, administration of a neutralizing mAb to human ICOS reduced Treg proportions and numbers and improved CD4 + T cell proliferation in humanized mice.	treg	67-71	inducible T cell costimulator	Homo sapiens	54-58	
30319662-10	2018	These results suggest that ICOSL expression by AML cells may directly drive Treg expansion as a mechanism of immune evasion and ICOS+ Treg cell frequency is a better prognostic predictor in patients with AML.	treg	76-80	inducible T cell costimulator	Homo sapiens	27-31	
32573411-11	2021	CONCLUSIONS: Our data reveal a crucial role of Treg immune senescence for the occurrence of disease flares in SLE patients, with ICOS+-Treg cells being most affected.	treg	47-51	inducible T cell costimulator	Homo sapiens	129-133