PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
31386893-10	2019	The NaHS-induced ANP secretion during hypoxia was also blocked by the pretreatment with HIF-1alpha inhibitor (2-methoxy- estradiol), PPAR-gamma inhibitor (GW9662) but not by NOS inhibitor (L-NAME) and endothelin receptor inhibitor (bosentan).	NG-Nitroarginine Methyl Ester	189-195	natriuretic peptide A	Rattus norvegicus	17-20	
10818074-2	2000	N(G)-nitro-L-arginine methyl ester bolus (L-NAME, 1 mg/kg) reverted the decrease in mean arterial pressure induced by ANP administration (5 microg/kg bolus and 0.2 microg x kg(-1) x min(-1) infusion), and the injection of L-NAME before peptide administration suppressed the ANP hypotensive response.	NG-Nitroarginine Methyl Ester	0-34	natriuretic peptide A	Rattus norvegicus	118-121	
15177930-3	2004	The aim of this study was to evaluate ANP plasma levels, content and mRNA in atria of male Wistar rats chronically treated with oral Nomega-nitro-L-arginine methyl ester (L-NAME) after 4 weeks of high-salt diet.	NG-Nitroarginine Methyl Ester	133-169	natriuretic peptide A	Rattus norvegicus	38-41	
15177930-3	2004	The aim of this study was to evaluate ANP plasma levels, content and mRNA in atria of male Wistar rats chronically treated with oral Nomega-nitro-L-arginine methyl ester (L-NAME) after 4 weeks of high-salt diet.	NG-Nitroarginine Methyl Ester	171-177	natriuretic peptide A	Rattus norvegicus	38-41	
30388373-4	2019	Systemic L-NAME treatment induced a dose-dependent increase in blood pressure and increased mRNA levels of atrial natriuretic peptide (ANP) and phosphorylation levels of p44/42 MAPK without any change in cardiac mass.	NG-Nitroarginine Methyl Ester	9-15	natriuretic peptide A	Rattus norvegicus	107-133	
20974001-3	2010	RESULTS: Injections of L-NAME or ANG-II produced an increase in plasma vasopressin (VP), oxytocin (OT) and atrial natriuretic peptide (ANP) levels, an increase in water and sodium intake, mean arterial blood pressure and sodium excretion, and a reduction of urinary volume.	NG-Nitroarginine Methyl Ester	23-29	natriuretic peptide A	Rattus norvegicus	107-133	
20071611-5	2010	N(omega)-nitro-l-arginine methyl ester prevented the effects of leptin on the reduction of ANP level.	NG-Nitroarginine Methyl Ester	0-38	natriuretic peptide A	Rattus norvegicus	91-94	
12198334-7	2002	>L-NAME treatment increased ventricular atrial natriuretic peptide (ANP) and B-type natriuretic peptide (BNP) mRNA levels and immunoreactive BNP levels significantly.	NG-Nitroarginine Methyl Ester	4-10	natriuretic peptide A	Rattus norvegicus	43-69	
12198334-7	2002	>L-NAME treatment increased ventricular atrial natriuretic peptide (ANP) and B-type natriuretic peptide (BNP) mRNA levels and immunoreactive BNP levels significantly.	NG-Nitroarginine Methyl Ester	4-10	natriuretic peptide A	Rattus norvegicus	71-74	
12198334-8	2002	Losartan therapy decreased the >l-NAME-induced ventricular ANP gene expression by 69% (p < 0.05) and also reduced ventricular BNP mRNA levels so that it did not differ from control.	NG-Nitroarginine Methyl Ester	35-41	natriuretic peptide A	Rattus norvegicus	62-65	
12198334-11	2002	Results suggest that >l-NAME-induced hypertension and the associated activation of ventricular ANP and BNP gene expression are, at least in part, mediated by angiotensin II, whereas the resistance vessel hypertrophy following nitric oxide synthase inhibition is angiotensin II independent.	NG-Nitroarginine Methyl Ester	25-31	natriuretic peptide A	Rattus norvegicus	98-101	
10945935-2	2000	The atrial tissue expression of ANP mRNA was determined in rats treated with an inhibitor of NO synthesis, N(G)-nitro-L-arginine methyl ester (L-NAME), for 4 weeks.	NG-Nitroarginine Methyl Ester	107-141	natriuretic peptide A	Rattus norvegicus	32-35	
10945935-2	2000	The atrial tissue expression of ANP mRNA was determined in rats treated with an inhibitor of NO synthesis, N(G)-nitro-L-arginine methyl ester (L-NAME), for 4 weeks.	NG-Nitroarginine Methyl Ester	143-149	natriuretic peptide A	Rattus norvegicus	32-35	
10818074-2	2000	N(G)-nitro-L-arginine methyl ester bolus (L-NAME, 1 mg/kg) reverted the decrease in mean arterial pressure induced by ANP administration (5 microg/kg bolus and 0.2 microg x kg(-1) x min(-1) infusion), and the injection of L-NAME before peptide administration suppressed the ANP hypotensive response.	NG-Nitroarginine Methyl Ester	222-228	natriuretic peptide A	Rattus norvegicus	118-121	
10818074-5	2000	In both cases, L-NAME prevented the ANP effect on NADPH-diaphorase activity.	NG-Nitroarginine Methyl Ester	15-21	natriuretic peptide A	Rattus norvegicus	36-39	
10818074-2	2000	N(G)-nitro-L-arginine methyl ester bolus (L-NAME, 1 mg/kg) reverted the decrease in mean arterial pressure induced by ANP administration (5 microg/kg bolus and 0.2 microg x kg(-1) x min(-1) infusion), and the injection of L-NAME before peptide administration suppressed the ANP hypotensive response.	NG-Nitroarginine Methyl Ester	42-48	natriuretic peptide A	Rattus norvegicus	118-121	
8613225-6	1996	Pretreatment with 10(-4) mol/L N-nitro-L-arginine methyl ester (L-NAME) or 5 x 10(-6) mol/L indomethacin blocked CNP-induced dilation; dilation by ANF was unaffected by indomethacin (52 +/- 25%, n=5) and potentiated by L-NAME (73 +/- 14%, n=5).	NG-Nitroarginine Methyl Ester	64-70	natriuretic peptide A	Rattus norvegicus	147-150	
10458519-5	1999	A similar potentiation of the ANP-response was observed by pre-treatment with N(G)-nitro-L-arginine methyl ester (L-NAME, 3 x 10(-4) mol/l) or methylene blue (2 x 10(-5) mol/l) in unrubbed HR thoracic aorta.	NG-Nitroarginine Methyl Ester	78-112	natriuretic peptide A	Rattus norvegicus	30-33	
10458519-5	1999	A similar potentiation of the ANP-response was observed by pre-treatment with N(G)-nitro-L-arginine methyl ester (L-NAME, 3 x 10(-4) mol/l) or methylene blue (2 x 10(-5) mol/l) in unrubbed HR thoracic aorta.	NG-Nitroarginine Methyl Ester	114-120	natriuretic peptide A	Rattus norvegicus	30-33	
8883033-6	1996	Plasma atrial natriuretic peptide (ANP) levels were elevated in the nephritis (p < 0.001) and in the nephritis-L-NAME groups (p < 0.05.	NG-Nitroarginine Methyl Ester	114-120	natriuretic peptide A	Rattus norvegicus	7-33	
7867578-0	1995	Role of nitric oxide on cardiac hormone secretion: effect of NG-nitro-L-arginine methyl ester on atrial natriuretic peptide and brain natriuretic peptide release.	NG-Nitroarginine Methyl Ester	61-93	natriuretic peptide A	Rattus norvegicus	97-123	
8396039-9	1993	In contrast, L-NAME reduced the aorta cGMP concentration 6-fold, despite an increased level of circulating ANF.	NG-Nitroarginine Methyl Ester	13-19	natriuretic peptide A	Rattus norvegicus	107-110	
35203062-9	2022	The suppression of ANP secretion by CORM-2 was attenuated by pretreatment with 5-hydroxydecanoic acid, paxilline, and 1H-(1,2,4) oxadiazolo (4,3-a) quinoxalin-1-one, but not by diltiazem, wortmannin, LY-294002, or NG-nitro-L-arginine methyl ester.	NG-Nitroarginine Methyl Ester	214-246	natriuretic peptide A	Rattus norvegicus	19-22