PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 10647994-7 2000 Immunohistochemical localization of P-selectin expression on mesenteric venular endothelium was significantly increased after exposure to L-NAME and after hemorrhage-reinfusion, which was significantly attenuated by LXR-1035 (P<0.05). NG-Nitroarginine Methyl Ester 138-144 selectin P Rattus norvegicus 36-46 16020392-9 2005 L-NAME provoked increased expression of P-selectin, E-selectin, ICAM-1, and VCAM-1 in arterial endothelium, which was attenuated by losartan pretreatment. NG-Nitroarginine Methyl Ester 0-6 selectin P Rattus norvegicus 40-50 10591666-9 1999 Moreover, immunohistochemical analysis demonstrated significantly increased P-selectin expression on the mesenteric venular endothelium after superfusion with either L-NAME (P<0.01) or thrombin (P<0.01), which was significantly attenuated by simvastatin. NG-Nitroarginine Methyl Ester 166-172 selectin P Rattus norvegicus 76-86 10684448-6 1997 l-NAME enhanced the contractile response in response to norepinephrine, suppressed the relaxant response to acetyleholine, promoted leukocyte adherence to the endothelium and resulted in P-selectin expression on the aortic endothelium. NG-Nitroarginine Methyl Ester 0-6 selectin P Rattus norvegicus 187-197 9275235-6 1997 Immunohistochemical up-regulation of P-selectin expression on intestinal venular endothelium was significantly increased (P < 0.01) after exposure to L-NAME, and this was significantly attenuated by these lipoxin analogs (P < 0.01). NG-Nitroarginine Methyl Ester 153-159 selectin P Rattus norvegicus 37-47 9275235-7 1997 Thus, in vivo superfusion of the rat mesentery with stable lipoxin analogs at 10 nmol/liter reduces L-NAME-induced leukocyte rolling and adherence in the mesenteric rat microvasculature by attenuating P-selectin expression. NG-Nitroarginine Methyl Ester 100-106 selectin P Rattus norvegicus 201-211 9843819-11 1998 The mechanism of L-NAME-enhanced neutrophil infiltration may be due to the fact that the ratios of P-selectin and intercellular adhesion molecule 1 (ICAM-1) mRNA to glyceraldehyde-3-phosphate dehydrogenase mRNA extracted from the ischemic lobes of I/R-L-NAME rats were significantly increased when compared with the I/R-SNAP group. NG-Nitroarginine Methyl Ester 17-23 selectin P Rattus norvegicus 99-109 10684448-10 1997 The l-NAME-mediated increase in myeloperoxidase activity and leukocyte deposition in the spleen, but not in the lungs, was abolished by treatment of rats with the P-selectin antagonist CY1503 administered 30 minutes prior to l-NAME. NG-Nitroarginine Methyl Ester 4-10 selectin P Rattus norvegicus 163-173 10684448-10 1997 The l-NAME-mediated increase in myeloperoxidase activity and leukocyte deposition in the spleen, but not in the lungs, was abolished by treatment of rats with the P-selectin antagonist CY1503 administered 30 minutes prior to l-NAME. NG-Nitroarginine Methyl Ester 225-231 selectin P Rattus norvegicus 163-173 9045871-5 1997 In vivo, in the rat mesentery, thrombin (0.5 U/ml) or N(G)-nitro-L-arginine-methyl ester (50 microM) significantly increased venular leukocyte rolling and adherence, which were also significantly (P < 0.01) attenuated by ONOO (800 nM) accompanied by reduced P-selectin expression on the endothelial cell surface. NG-Nitroarginine Methyl Ester 54-88 selectin P Rattus norvegicus 261-271 7685251-5 1993 Monoclonal antibodies (MAbs) directed against adhesion molecules CD11/CD18, ICAM-1, or P-selectin, but not a nonbinding MAb, attenuated the albumin leakage induced by L-NAME. NG-Nitroarginine Methyl Ester 167-173 selectin P Rattus norvegicus 87-97 9121223-8 1996 Exposure of rat mesentery to L-NAME consistently increased P-selectin surface expression (p < 0.01) on the vascular endothelium which was significantly attenuated by defibrotide (p < 0.05). NG-Nitroarginine Methyl Ester 29-35 selectin P Rattus norvegicus 59-69 9121223-10 1996 Since P-selectin was upregulated by the specific nitric oxide synthase inhibitor L-NAME, the present study also confirms the crucial role exerted by nitric oxide in attenuating leukocyte-endothelial cell interaction during various pathophysiological conditions. NG-Nitroarginine Methyl Ester 81-87 selectin P Rattus norvegicus 6-16 8604008-8 1996 This action of TMS appears to be mediated by reduction of P-selectin expression because immunohistochemical analysis demonstrated that TMS significantly attenuated endothelial P-selectin expression in the L-NAME-superfused rat mesenteric microvasculature. NG-Nitroarginine Methyl Ester 205-211 selectin P Rattus norvegicus 58-68 8604008-8 1996 This action of TMS appears to be mediated by reduction of P-selectin expression because immunohistochemical analysis demonstrated that TMS significantly attenuated endothelial P-selectin expression in the L-NAME-superfused rat mesenteric microvasculature. NG-Nitroarginine Methyl Ester 205-211 selectin P Rattus norvegicus 176-186 8604008-9 1996 Similarly, TMS markedly attenuated rapid P-selectin expression in rat platelets stimulated with either thrombin or L-NAME assessed by flow cytometry. NG-Nitroarginine Methyl Ester 115-121 selectin P Rattus norvegicus 41-51 7583592-11 1995 Furthermore, all rings treated with ox-LDL or L-NAME demonstrated marked expression of P-selectin leukocyte adhesion molecules, determined by immunohistochemistry. NG-Nitroarginine Methyl Ester 46-52 selectin P Rattus norvegicus 87-97 7523213-8 1994 Immunohistochemistry showed a significant increase in P-selectin expression after 60 minutes of superfusion with L-NAME, which was attenuated by L-arginine, hSOD, and 8-br-cGMP. NG-Nitroarginine Methyl Ester 113-119 selectin P Rattus norvegicus 54-64 8024002-7 1994 Pretreatment with anti-intracellular adhesion molecule-1, anti-P-selectin, or anti-CD18 monoclonal antibody attenuated L-NAME-elicited venular leukocyte adhesion without abolishing CDCF fluorescence in situ. NG-Nitroarginine Methyl Ester 119-125 selectin P Rattus norvegicus 63-73 8838455-5 1996 Moreover, immunohistochemical localization of P-selectin expression on mesenteric venules was significantly increased (P < 0.01) after exposure to L-NAME, which was significantly attenuated by oligotide (P < 0.05). NG-Nitroarginine Methyl Ester 150-156 selectin P Rattus norvegicus 46-56 8838455-7 1996 Stimulation of rat platelets with L-NAME significantly (P < 0.05) increased the fluorescence intensity of P-selectin, while the concomitant treatment of isolated rat platelets with L-NAME plus oligotide significantly (P < 0.005) attenuated P-selectin fluorescence intensity. NG-Nitroarginine Methyl Ester 34-40 selectin P Rattus norvegicus 109-119 8838455-7 1996 Stimulation of rat platelets with L-NAME significantly (P < 0.05) increased the fluorescence intensity of P-selectin, while the concomitant treatment of isolated rat platelets with L-NAME plus oligotide significantly (P < 0.005) attenuated P-selectin fluorescence intensity. NG-Nitroarginine Methyl Ester 34-40 selectin P Rattus norvegicus 246-256 8838455-7 1996 Stimulation of rat platelets with L-NAME significantly (P < 0.05) increased the fluorescence intensity of P-selectin, while the concomitant treatment of isolated rat platelets with L-NAME plus oligotide significantly (P < 0.005) attenuated P-selectin fluorescence intensity. NG-Nitroarginine Methyl Ester 184-190 selectin P Rattus norvegicus 109-119 8838455-7 1996 Stimulation of rat platelets with L-NAME significantly (P < 0.05) increased the fluorescence intensity of P-selectin, while the concomitant treatment of isolated rat platelets with L-NAME plus oligotide significantly (P < 0.005) attenuated P-selectin fluorescence intensity. NG-Nitroarginine Methyl Ester 184-190 selectin P Rattus norvegicus 246-256 7685251-7 1993 Only 8-br-cGMP and the P-selectin MAb attenuated the platelet-leukocyte aggregation elicited by L-NAME. NG-Nitroarginine Methyl Ester 96-102 selectin P Rattus norvegicus 23-33