PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
10644521-8	2000	Exposure of BAEC without L-Arg to substance P and a Ca(2+) ionophore (A-23187) increased O(-)(2)* formation, which was blocked with concurrent presence of L-Arg or the NOS antagonist N(omega)-nitro-L-arginine methyl ester.	NG-Nitroarginine Methyl Ester	183-221	tachykinin precursor 1	Homo sapiens	34-45	
21946672-8	2011	Tetrodotoxin or N(G)-nitro-L-arginine methyl ester pretreatment significantly enhanced betaAla(8)-NKA(4-10)-induced contraction.	NG-Nitroarginine Methyl Ester	16-50	tachykinin precursor 1	Homo sapiens	98-101	
17537972-7	2007	Local anesthesia of the masseter nerve prevented the increase in GFAP and IL-1beta after inflammation, and substance P, a prototype neurotransmitter of primary afferents, induced similar increases in GFAP and IL-1beta, which was blocked by a nitric oxide synthase inhibitor N(G)-nitro-L-arginine methyl ester.	NG-Nitroarginine Methyl Ester	274-308	tachykinin precursor 1	Homo sapiens	107-118	
17023511-15	2006	The CVC response to whole-body heat stress in L-NAME sites was significantly reduced (32 +/- 3% CVC(max); P < 0.001) compared to both control sites and sites pretreated with substance P.	NG-Nitroarginine Methyl Ester	46-52	tachykinin precursor 1	Homo sapiens	177-188	
10666071-8	2000	However, in endothelium-denuded arteries transduced with recombinant eNOS, bradykinin and substance P caused relaxations that were abolished in the presence of the NOS inhibitor N(G)-nitro-L-arginine methyl ester.	NG-Nitroarginine Methyl Ester	178-212	tachykinin precursor 1	Homo sapiens	90-101	
16123103-15	2005	Substance P produced a dose-dependent increase in skin blood flow with the concentrations of substance P tested, which was significantly attenuated in the presence of L-NAME and the combination of L-NAME plus pyrilamine.	NG-Nitroarginine Methyl Ester	167-173	tachykinin precursor 1	Homo sapiens	0-11	
16123103-15	2005	Substance P produced a dose-dependent increase in skin blood flow with the concentrations of substance P tested, which was significantly attenuated in the presence of L-NAME and the combination of L-NAME plus pyrilamine.	NG-Nitroarginine Methyl Ester	197-203	tachykinin precursor 1	Homo sapiens	0-11	
11122309-4	2000	In the presence of Nomega-nitro-L-arginine methyl ester (nitric oxide synthase inhibitor), 10(-6) M propofol still enhanced the substance P-induced relaxation in arteries but not veins, whereas 10(-4) M propofol inhibited the relaxation in both arteries (rightward shift of the concentration-response curve) and veins (28+/-7.5%, n = 8).	NG-Nitroarginine Methyl Ester	19-55	tachykinin precursor 1	Homo sapiens	128-139	
8567541-7	1995	The effects of Ro-24-9981 on substance P-induced responses were significantly attenuated by NG-nitro-L-arginine methyl ester and restored by L-arginine (P < 0.05).	NG-Nitroarginine Methyl Ester	92-124	tachykinin precursor 1	Homo sapiens	29-40	
9016405-8	1996	NG-nitro-L-arginine methyl ester (10(-4) M), an inhibitor of nitric oxide synthase, potentiated the responses to norepinephrine in artery rings with endothelium, nearly abolished the acetylcholine-induced relaxation, and attenuated the relaxation induced by substance P.	NG-Nitroarginine Methyl Ester	0-32	tachykinin precursor 1	Homo sapiens	258-269	
7511218-5	1994	SP caused concentration-related, endothelium-dependent relaxations of the splenic artery that were inhibited by 100 microM L-NAME, indicating that the relaxations could be attributed to the stimulated release of NO from endothelial cells.	NG-Nitroarginine Methyl Ester	123-129	tachykinin precursor 1	Homo sapiens	0-2	
7537470-4	1995	The effect of increased microvessel permeability induced by substance P (10(-11) M) was blocked with the nonpeptide substance P receptor antagonist CP-96,345 and NG-nitro-L-arginine methyl ester (L-NAME), an inhibitor of nitric oxide synthase.	NG-Nitroarginine Methyl Ester	162-194	tachykinin precursor 1	Homo sapiens	60-71	
7537470-4	1995	The effect of increased microvessel permeability induced by substance P (10(-11) M) was blocked with the nonpeptide substance P receptor antagonist CP-96,345 and NG-nitro-L-arginine methyl ester (L-NAME), an inhibitor of nitric oxide synthase.	NG-Nitroarginine Methyl Ester	196-202	tachykinin precursor 1	Homo sapiens	60-71	
7529915-4	1995	Maximal relaxation induced by substance P was not significantly affected by indomethacin (10 mumol/L), but was reduced from 58.7% (95% confidence interval [CI] 41.3-76.1) in control experiments to 24.7% (95% CI 18.3-31.1) after luminal rubbing and to 32.3% (95% CI 19.8-44.8) after exposure to L-NAME (0.1 mmol/L) (P = .001).	NG-Nitroarginine Methyl Ester	294-300	tachykinin precursor 1	Homo sapiens	30-41	
7516884-8	1994	The similarity in the inhibitory effects of N omega-nitro-L-arginine methyl ester and N omega-nitro-L-arginine on responses to acetylcholine, bradykinin, and substance P suggest that the L-arginine analog, N omega-nitro-L-arginine, as well as the methyl ester of N omega-nitro-L-arginine, are useful probes for studying endothelium-dependent vasodilator responses in the mesenteric vascular bed of the cat.	NG-Nitroarginine Methyl Ester	44-81	tachykinin precursor 1	Homo sapiens	158-169	
8250644-7	1993	L-NAME inhibited the relaxation induced by substance P in endothelium-intact preparations.	NG-Nitroarginine Methyl Ester	0-6	tachykinin precursor 1	Homo sapiens	43-54	
7680535-6	1993	The NO synthesis inhibitor, N omega-nitro-L-argininemethyl ester (L-NAME), and the soluble guanylate cyclase inhibitor, methylene blue (MB), selectively inhibited pulmonary vasodilator responses to substance P and to acetylcholine.	NG-Nitroarginine Methyl Ester	28-64	tachykinin precursor 1	Homo sapiens	198-209	
32673994-7	2020	Most importantly, N(omega)-nitro-L-arginine methyl ester (L-NAME, a nitric oxide synthase inhibitor) decreased protein levels of nitrotyrosine and concomitantly increased expression of membrane-bound fractalkine after exposure to SP.	NG-Nitroarginine Methyl Ester	18-56	tachykinin precursor 1	Homo sapiens	230-232	
32673994-7	2020	Most importantly, N(omega)-nitro-L-arginine methyl ester (L-NAME, a nitric oxide synthase inhibitor) decreased protein levels of nitrotyrosine and concomitantly increased expression of membrane-bound fractalkine after exposure to SP.	NG-Nitroarginine Methyl Ester	58-64	tachykinin precursor 1	Homo sapiens	230-232