PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 23477594-1 2013 We investigated the effect of dietary supplementation of sodium nitroprusside (SNP), a nitric oxide (NO) donor, and N-nitro-L-arginine methyl ester (L-NAME), a NO inhibitor, on neuronal nitric oxide synthase (nNOS) expression in and motility of small intestinum in broilers. NG-Nitroarginine Methyl Ester 149-155 nitric oxide synthase 1 Homo sapiens 177-207 25804308-8 2015 NOS inhibitor (L-NG-Nitroarginine Methyl Ester, L-NAME) or eNOS gene deletion (eNOS(-/-)) abolished Ang II-induced membrane trafficking of AT2R, nNOS protein expression and activity. NG-Nitroarginine Methyl Ester 15-46 nitric oxide synthase 1 Homo sapiens 145-149 23477594-9 2013 nNOS expression clearly was suppressed on day 21 by the diet supplemented with L-NAME, while the diet supplemented with SNP stimulated nNOS expression on day 21. NG-Nitroarginine Methyl Ester 79-85 nitric oxide synthase 1 Homo sapiens 0-4 23207953-9 2012 Additionally, LH and L-NAME had similar down-regulating effects on the expression of TGF-beta1 and pSmad2/3, which indicated that TGF-beta/Smad pathway might be a downstream signaling of nNOS/NO during LH treatment. NG-Nitroarginine Methyl Ester 21-27 nitric oxide synthase 1 Homo sapiens 187-191 23525247-7 2013 ATP also stimulated NO production in GPN neurones, as revealed by an increase in DAF fluorescence; this NO signal was inhibited by purinergic blockers, chelators of extracellular Ca(2+), the nNOS inhibitor l-NAME and the NO scavenger carboxy-PTIO. NG-Nitroarginine Methyl Ester 206-212 nitric oxide synthase 1 Homo sapiens 191-195 19073841-7 2009 Furthermore, inhibition of neuronal nitric oxide synthase (nNOS), NO, and cGMP significantly blocked the inhibitory effects of relaxin on alpha-SMA and Smad2 phosphorylation, while the NO inhibitor, L-nitroarginine methyl ester (hydrochloride) (L-NAME) significantly blocked the inhibitory actions of relaxin on collagen concentration in vivo. NG-Nitroarginine Methyl Ester 245-251 nitric oxide synthase 1 Homo sapiens 27-57 19073841-7 2009 Furthermore, inhibition of neuronal nitric oxide synthase (nNOS), NO, and cGMP significantly blocked the inhibitory effects of relaxin on alpha-SMA and Smad2 phosphorylation, while the NO inhibitor, L-nitroarginine methyl ester (hydrochloride) (L-NAME) significantly blocked the inhibitory actions of relaxin on collagen concentration in vivo. NG-Nitroarginine Methyl Ester 245-251 nitric oxide synthase 1 Homo sapiens 59-63 15978003-8 2005 Moreover, the effects of 7-nitroindazole, a selective nNOS inhibitor, mimicked the effects of L-NAME regarding both the enhancement of the ATP-induced Ca(2+) response and the attenuation of NO production. NG-Nitroarginine Methyl Ester 94-100 nitric oxide synthase 1 Homo sapiens 54-58 16331176-8 2005 RESULTS: eNOS and nNOS activity was significantly reduced in animals that received L-NAME alone or the combination with S-PBN. NG-Nitroarginine Methyl Ester 83-89 nitric oxide synthase 1 Homo sapiens 18-22 15170357-4 2004 ROS production could be prevented by the NOS inhibitor L-NAME, suggesting nNOS itself is involved in ROS generation. NG-Nitroarginine Methyl Ester 55-61 nitric oxide synthase 1 Homo sapiens 74-78 14602725-9 2004 Inhibition of nNOS-generated NO* with the competitive NOS inhibitor, NG-nitro-l-arginine methyl ester, in cells grown in l-arginine restored ERK1/2 activation to levels similar to that found when nNOS was activated in l-arginine-free media. NG-Nitroarginine Methyl Ester 69-101 nitric oxide synthase 1 Homo sapiens 14-18 15161750-2 2004 We now bring evidence that two inhibitors of nNOS, N-omega-nitro-l-arginine methyl ester (l-NAME) and 7-nitroindazole (7-NI), increase glucose-induced insulin secretion but affect beta-cell function differently. NG-Nitroarginine Methyl Ester 51-88 nitric oxide synthase 1 Homo sapiens 45-49 15161750-2 2004 We now bring evidence that two inhibitors of nNOS, N-omega-nitro-l-arginine methyl ester (l-NAME) and 7-nitroindazole (7-NI), increase glucose-induced insulin secretion but affect beta-cell function differently. NG-Nitroarginine Methyl Ester 90-96 nitric oxide synthase 1 Homo sapiens 45-49 14602725-9 2004 Inhibition of nNOS-generated NO* with the competitive NOS inhibitor, NG-nitro-l-arginine methyl ester, in cells grown in l-arginine restored ERK1/2 activation to levels similar to that found when nNOS was activated in l-arginine-free media. NG-Nitroarginine Methyl Ester 69-101 nitric oxide synthase 1 Homo sapiens 196-200 8611587-9 1996 The observed g values of the nNOS heme were 7.68, and 1.81 and were unchanged by occupation of the substrate binding site by L-arginine or NAME. NG-Nitroarginine Methyl Ester 139-143 nitric oxide synthase 1 Homo sapiens 29-33 9870939-6 1999 The NOS inhibitor L-nitroarginine methyl ester is neuroprotective in wild-type and nNOS-/- cultures, confirming the role of iNOS-derived NO in gp41 neurotoxicity. NG-Nitroarginine Methyl Ester 18-46 nitric oxide synthase 1 Homo sapiens 83-87 10760483-3 2000 Our results indicate that capsaicin (1 microM)-evoked release of immunoreactive calcitonin gene-related peptide (iCGRP) is significantly reduced in the presence of the NO synthase inhibitor, L-NAME (10-400 nM; F(3,45)=68.38; P<0.001) and, the selective nNOS inhibitor, 3-bromo-7-nitroindazole (170-680 nM; F(5,48)=56.2; P<0. NG-Nitroarginine Methyl Ester 191-197 nitric oxide synthase 1 Homo sapiens 256-260 9150420-0 1997 Potent inhibition of human neuronal nitric oxide synthase by N(G)-nitro-L-arginine methyl ester results from contaminating N(G)-nitro-L-arginine. NG-Nitroarginine Methyl Ester 61-95 nitric oxide synthase 1 Homo sapiens 36-57 9150420-1 1997 N(G)-Nitro-L-arginine methyl ester (L-NAME), inhibits the three isozymes of nitric oxide synthase (NOS) in vitro and in vivo. NG-Nitroarginine Methyl Ester 0-34 nitric oxide synthase 1 Homo sapiens 76-97 9150420-1 1997 N(G)-Nitro-L-arginine methyl ester (L-NAME), inhibits the three isozymes of nitric oxide synthase (NOS) in vitro and in vivo. NG-Nitroarginine Methyl Ester 36-42 nitric oxide synthase 1 Homo sapiens 76-97 9150420-3 1997 L-NAME was a time-dependent inhibitor of neuronal NOS (nNOS). NG-Nitroarginine Methyl Ester 0-6 nitric oxide synthase 1 Homo sapiens 41-53 9150420-3 1997 L-NAME was a time-dependent inhibitor of neuronal NOS (nNOS). NG-Nitroarginine Methyl Ester 0-6 nitric oxide synthase 1 Homo sapiens 55-59 9150420-5 1997 The time-dependent inhibition of nNOS by L-NAME was the result of this time-dependent formation of L-NA. NG-Nitroarginine Methyl Ester 41-47 nitric oxide synthase 1 Homo sapiens 33-37 9150420-7 1997 These data suggested that L-NAME itself was a weak and rapidly reversible inhibitor of nNOS. NG-Nitroarginine Methyl Ester 26-32 nitric oxide synthase 1 Homo sapiens 87-91 9150420-8 1997 Most of the inhibition of nNOS by a solution of L-NAME is the result of the formation of L-NA. NG-Nitroarginine Methyl Ester 48-54 nitric oxide synthase 1 Homo sapiens 26-30 29552127-10 2018 L-NAME increased the cell damage caused by TMZ while reducing the oxidative stress at 48 h. The preferential nNOS inhibitor 7-NI also improved the TMZ effects. NG-Nitroarginine Methyl Ester 0-6 nitric oxide synthase 1 Homo sapiens 109-113 32193098-5 2020 Conversely, we show that NOS1 inhibition by N(G)-nitro-L-arginine methyl ester (L-NAME) suppresses OxLDL uptake and proinflammatory cytokine expression. NG-Nitroarginine Methyl Ester 44-78 nitric oxide synthase 1 Homo sapiens 25-29 32193098-5 2020 Conversely, we show that NOS1 inhibition by N(G)-nitro-L-arginine methyl ester (L-NAME) suppresses OxLDL uptake and proinflammatory cytokine expression. NG-Nitroarginine Methyl Ester 80-86 nitric oxide synthase 1 Homo sapiens 25-29 31699997-6 2019 The roles of three isoforms of nitric oxide synthases (nNOS, eNOS, and iNOS) were validated using L-NAME (eNOS inhibitor), SMT (iNOS inhibitor), and spermidine (nNOS inhibitor). NG-Nitroarginine Methyl Ester 98-104 nitric oxide synthase 1 Homo sapiens 55-59 30713473-9 2018 The expression of nNOS and p-ERK proteins were down-regulated when the T98G cells were pretreated with CsA (1 nM, 10 nM, and 100 nM), CAIP (50 microM), and L-NAME (0.1 mM) as compared to MOR. NG-Nitroarginine Methyl Ester 156-162 nitric oxide synthase 1 Homo sapiens 18-22 28243469-8 2017 Moreover, in an in vivo study, the NOS1 inhibitor N(G)-nitro-L-arginine methyl ester activated AKT/mTOR signaling and promoted autophagy in xenograph tumors. NG-Nitroarginine Methyl Ester 50-84 nitric oxide synthase 1 Homo sapiens 35-39