PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
18296272-4	2008	Strong leptin immunopositivity was observed in brown adipocytes cytoplasm of all room-acclimated groups, but nuclear leptin positivity was found only in L-NAME treated rats.	NG-Nitroarginine Methyl Ester	153-159	leptin	Rattus norvegicus	117-123	
21068181-11	2011	Pretreatment of explants with the NO synthase inhibitor Nomega-nitro-l-arginine methyl ester eliminated the effect of leptin on lipolysis, glyceroneogenesis, and expression of the HSL, Pck1, and PPARgamma genes.	NG-Nitroarginine Methyl Ester	56-92	leptin	Rattus norvegicus	118-124	
19649339-8	2009	L-NAME pretreatment caused complete inhibition of the relaxant responses to leptin in the control aortic rings, while it induced a reduction in these responses in the diabetic rings (P < 0.05).	NG-Nitroarginine Methyl Ester	0-6	leptin	Rattus norvegicus	76-82	
18296272-5	2008	In cold-acclimated control and L-NAME treated rats leptin immunopositivity was absent, while L-arginine treatment reversed the cold-induced suppression of leptin expression.	NG-Nitroarginine Methyl Ester	31-37	leptin	Rattus norvegicus	51-57	
22019256-6	2012	The lordosis induced by leptin at 1 and 2h after infusion was significantly reduced by the previous injection of either L-NAME or by ODQ.	NG-Nitroarginine Methyl Ester	120-126	leptin	Rattus norvegicus	24-30	
20071611-5	2010	N(omega)-nitro-l-arginine methyl ester prevented the effects of leptin on the reduction of ANP level.	NG-Nitroarginine Methyl Ester	0-38	leptin	Rattus norvegicus	64-70	
19323984-6	2009	The peripheral, hypotensive effect of chronic leptin in FBNF1 rats was prevented by blockade of nitric oxide production with L-NAME treatment.	NG-Nitroarginine Methyl Ester	125-131	leptin	Rattus norvegicus	46-52	
11799081-11	2002	The difference in leptin-induced contractile response between the WKY and the SHR groups was abolished by the NOS inhibitor, Nomega-nitro-L-arginine methyl ester (L-NAME), but not by elevated extracellular Ca(2+).	NG-Nitroarginine Methyl Ester	125-161	leptin	Rattus norvegicus	18-24	
16015682-8	2005	In N(G)-nitro L-arginine methyl ester (L-NAME)-pretreated animals, the ulcer prevention ability of leptin in AE-induced ulcer was significantly reduced, compared to rats without L-NAME pretreatment.	NG-Nitroarginine Methyl Ester	3-37	leptin	Rattus norvegicus	99-105	
16015682-8	2005	In N(G)-nitro L-arginine methyl ester (L-NAME)-pretreated animals, the ulcer prevention ability of leptin in AE-induced ulcer was significantly reduced, compared to rats without L-NAME pretreatment.	NG-Nitroarginine Methyl Ester	39-45	leptin	Rattus norvegicus	99-105	
16015682-8	2005	In N(G)-nitro L-arginine methyl ester (L-NAME)-pretreated animals, the ulcer prevention ability of leptin in AE-induced ulcer was significantly reduced, compared to rats without L-NAME pretreatment.	NG-Nitroarginine Methyl Ester	178-184	leptin	Rattus norvegicus	99-105	
15229341-6	2004	In the Sprague-Dawley rats chronically administered l-NAME (n = 8), an intravenous bolus of 400 microg/kg of leptin did not increase sodium excretion.	NG-Nitroarginine Methyl Ester	52-58	leptin	Rattus norvegicus	109-115	
15229341-7	2004	Acute sodium nitroprusside infusion to Sprague-Dawley rats chronically treated with L-NAME (n = 8) was associated with partial restoration of the sodium excretory response to leptin administration.	NG-Nitroarginine Methyl Ester	84-90	leptin	Rattus norvegicus	175-181	
12226143-11	2002	The effect of leptin on plasma and urinary NO(x) was abolished by the NO synthase inhibitor, N(G)-nitro-L-arginine methyl ester (L-NAME) (30 mg/kg intraperitoneal) administered 15 minutes before leptin injection.	NG-Nitroarginine Methyl Ester	93-127	leptin	Rattus norvegicus	14-20	
12226143-11	2002	The effect of leptin on plasma and urinary NO(x) was abolished by the NO synthase inhibitor, N(G)-nitro-L-arginine methyl ester (L-NAME) (30 mg/kg intraperitoneal) administered 15 minutes before leptin injection.	NG-Nitroarginine Methyl Ester	93-127	leptin	Rattus norvegicus	195-201	
12226143-11	2002	The effect of leptin on plasma and urinary NO(x) was abolished by the NO synthase inhibitor, N(G)-nitro-L-arginine methyl ester (L-NAME) (30 mg/kg intraperitoneal) administered 15 minutes before leptin injection.	NG-Nitroarginine Methyl Ester	129-135	leptin	Rattus norvegicus	14-20	
12226143-11	2002	The effect of leptin on plasma and urinary NO(x) was abolished by the NO synthase inhibitor, N(G)-nitro-L-arginine methyl ester (L-NAME) (30 mg/kg intraperitoneal) administered 15 minutes before leptin injection.	NG-Nitroarginine Methyl Ester	129-135	leptin	Rattus norvegicus	195-201	
11799081-11	2002	The difference in leptin-induced contractile response between the WKY and the SHR groups was abolished by the NOS inhibitor, Nomega-nitro-L-arginine methyl ester (L-NAME), but not by elevated extracellular Ca(2+).	NG-Nitroarginine Methyl Ester	163-169	leptin	Rattus norvegicus	18-24	
11230354-9	2001	L-NAME+leptin increased arterial pressure by 40+/-6 mm Hg and heart rate by 79+/-19 bpm compared with pretreatment levels.	NG-Nitroarginine Methyl Ester	0-6	leptin	Rattus norvegicus	7-13	
11025360-22	2000	The protective and hyperemic effects of centrally administered leptin were abolished by vagotomy, producing a fall in plasma leptin levels, and significantly attenuated by sensory denervation with capsaicin, by pretreatment with the CGRP antagonist, CGRP(8-37), or with L-NAME.	NG-Nitroarginine Methyl Ester	270-276	leptin	Rattus norvegicus	63-69	
11040226-10	2000	Pretreatment with the NO synthase inhibitor N:(omega)-nitro-L-arginine methyl ester (L-NAME, 100 micromol/L) blocked leptin-induced inhibition of both peak shortening and fluorescence intensity change.	NG-Nitroarginine Methyl Ester	85-91	leptin	Rattus norvegicus	117-123	
10422768-17	1999	Indomethacin, which suppressed prostaglandin generation by approximately 90%, failed to influence leptin- or CCK-8-induced protection against ethanol, whereas L-NAME attenuated significantly CCK-8- and leptin-induced protection and hyperemia but addition to L-NAME of L-arginine, but not D-arginine, restored the protective and hyperemic effects of both hormones.	NG-Nitroarginine Methyl Ester	159-165	leptin	Rattus norvegicus	202-208