PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
22052438-0	2012	Cryptotanshinone down-regulates androgen receptor signaling by modulating lysine-specific demethylase 1 function.	cryptotanshinone	0-16	androgen receptor	Homo sapiens	32-49	
22052438-3	2012	In our study, we showed that cryptotanshinone inhibited the growth of AR-positive prostate cancer cells, suggesting that cryptotanshinone affected AR function.	cryptotanshinone	29-45	androgen receptor	Homo sapiens	70-72	
22052438-3	2012	In our study, we showed that cryptotanshinone inhibited the growth of AR-positive prostate cancer cells, suggesting that cryptotanshinone affected AR function.	cryptotanshinone	29-45	androgen receptor	Homo sapiens	147-149	
22052438-3	2012	In our study, we showed that cryptotanshinone inhibited the growth of AR-positive prostate cancer cells, suggesting that cryptotanshinone affected AR function.	cryptotanshinone	121-137	androgen receptor	Homo sapiens	70-72	
22052438-3	2012	In our study, we showed that cryptotanshinone inhibited the growth of AR-positive prostate cancer cells, suggesting that cryptotanshinone affected AR function.	cryptotanshinone	121-137	androgen receptor	Homo sapiens	147-149	
22052438-4	2012	Cryptotanshinone also profoundly inhibited the transcriptional activity of AR and suppressed the expression of several AR-target genes at the mRNA and the protein levels.	cryptotanshinone	0-16	androgen receptor	Homo sapiens	75-77	
22052438-4	2012	Cryptotanshinone also profoundly inhibited the transcriptional activity of AR and suppressed the expression of several AR-target genes at the mRNA and the protein levels.	cryptotanshinone	0-16	androgen receptor	Homo sapiens	119-121	
22052438-5	2012	At the molecular level, cryptotanshinone disrupted the interaction between AR and lysine-specific demethylase 1 (LSD1), and inhibited the complex of AR and LSD1 to the promoter of AR target genes without affecting the protein degradation and translocation of AR.	cryptotanshinone	24-40	androgen receptor	Homo sapiens	75-77	
22052438-5	2012	At the molecular level, cryptotanshinone disrupted the interaction between AR and lysine-specific demethylase 1 (LSD1), and inhibited the complex of AR and LSD1 to the promoter of AR target genes without affecting the protein degradation and translocation of AR.	cryptotanshinone	24-40	androgen receptor	Homo sapiens	149-151	
22052438-5	2012	At the molecular level, cryptotanshinone disrupted the interaction between AR and lysine-specific demethylase 1 (LSD1), and inhibited the complex of AR and LSD1 to the promoter of AR target genes without affecting the protein degradation and translocation of AR.	cryptotanshinone	24-40	androgen receptor	Homo sapiens	149-151	
22052438-5	2012	At the molecular level, cryptotanshinone disrupted the interaction between AR and lysine-specific demethylase 1 (LSD1), and inhibited the complex of AR and LSD1 to the promoter of AR target genes without affecting the protein degradation and translocation of AR.	cryptotanshinone	24-40	androgen receptor	Homo sapiens	149-151	
22052438-7	2012	These data suggest that cryptotanshinone functions via inhibition of LSD1, a protein that promotes AR-dependent transcriptional activity via derepression of H3K9.	cryptotanshinone	24-40	androgen receptor	Homo sapiens	99-101	
22052438-8	2012	In summary, we describe a novel mechanism whereby cryptotanshinone down-regulates AR signaling via functional inhibition of LSD1-mediated demethylation of H3K9 and represses the transcriptional activity of AR.	cryptotanshinone	50-66	androgen receptor	Homo sapiens	82-84	
22052438-8	2012	In summary, we describe a novel mechanism whereby cryptotanshinone down-regulates AR signaling via functional inhibition of LSD1-mediated demethylation of H3K9 and represses the transcriptional activity of AR.	cryptotanshinone	50-66	androgen receptor	Homo sapiens	206-208	
22154085-0	2012	Cryptotanshinone suppresses androgen receptor-mediated growth in androgen dependent and castration resistant prostate cancer cells.	cryptotanshinone	0-16	androgen receptor	Homo sapiens	28-45	
22154085-4	2012	Our results indicated that 0.5 muM CTS effectively suppresses the growth of AR-positive PCa cells, but has little effect on AR negative PC-3 cells and non-malignant prostate epithelial cells.	cryptotanshinone	35-38	androgen receptor	Homo sapiens	76-78	
22154085-5	2012	Furthermore, our data indicated that CTS could modulate AR transactivation and suppress the DHT-mediated AR target genes (PSA, TMPRSS2, and TMEPA1) expression in both androgen responsive PCa LNCaP cells and castration resistant CWR22rv1 cells.	cryptotanshinone	37-40	androgen receptor	Homo sapiens	56-58	
22154085-6	2012	Importantly, CTS selectively inhibits AR without repressing the activities of other nuclear receptors, including ERalpha, GR, and PR.	cryptotanshinone	13-16	androgen receptor	Homo sapiens	38-40	
22154085-7	2012	The mechanistic studies indicate that CTS functions as an AR inhibitor to suppress androgen/AR-mediated cell growth and PSA expression by blocking AR dimerization and the AR-coregulator complex formation.	cryptotanshinone	38-41	androgen receptor	Homo sapiens	58-60	
22154085-7	2012	The mechanistic studies indicate that CTS functions as an AR inhibitor to suppress androgen/AR-mediated cell growth and PSA expression by blocking AR dimerization and the AR-coregulator complex formation.	cryptotanshinone	38-41	androgen receptor	Homo sapiens	92-94	
22154085-7	2012	The mechanistic studies indicate that CTS functions as an AR inhibitor to suppress androgen/AR-mediated cell growth and PSA expression by blocking AR dimerization and the AR-coregulator complex formation.	cryptotanshinone	38-41	androgen receptor	Homo sapiens	92-94	
22154085-8	2012	Furthermore, we showed that CTS effectively inhibits CWR22Rv1 cell growth and expressions of AR target genes in the xenograft animal model.	cryptotanshinone	28-31	androgen receptor	Homo sapiens	93-95