PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
32706450-12	2020	In addition, Dex repressed Caspase-9 expression and apoptotic cell numbers in spinal cord tissues in CCI rats.	Dexmedetomidine	13-16	caspase 9	Rattus norvegicus	27-36	
34363182-10	2021	Furthermore, DEX and SB203582 diminished LPS-induced apoptosis, indicated by decreased Bax and Tom20 fluorescent double-stained cells, reduced annexin V-FITC/PI apoptosis rate, and reduced protein expression levels of Bax, cytochrome C, cleaved caspase-9, and cleaved caspase-3.	Dexmedetomidine	13-16	caspase 9	Rattus norvegicus	245-254	
34135573-9	2021	Results: High concentrations of DEX (>=100 muM) significantly reduced cell viability, induced neuronal apoptosis, upregulated the protein expression of cleaved caspase 3, Bax, cleaved caspase 9, and Cyt-c. DEX also considerably promoted the release of ROS.	Dexmedetomidine	32-35	caspase 9	Rattus norvegicus	184-193	
34135573-9	2021	Results: High concentrations of DEX (>=100 muM) significantly reduced cell viability, induced neuronal apoptosis, upregulated the protein expression of cleaved caspase 3, Bax, cleaved caspase 9, and Cyt-c. DEX also considerably promoted the release of ROS.	Dexmedetomidine	206-209	caspase 9	Rattus norvegicus	184-193	
32411568-13	2020	In cisplatin-treated cultured hippocampal neurons, Dex treatment and miR-429-3p overexpression significantly increased mitochondrial DNA gene mt-ND1expression and decreased caspase-9 expression.	Dexmedetomidine	51-54	caspase 9	Rattus norvegicus	173-182	
32158395-10	2020	DEX decreased the levels of blood urea nitrogen (BUN) and creatinine (Cre), urine kidney injury molecule-1 (KIM-1), neutrophil gelatinase-associated lipocalin (NGAL), reactive oxygen species (ROS), and apoptosis proteins (such as cleaved caspase-9 and cleaved caspase-3).	Dexmedetomidine	0-3	caspase 9	Rattus norvegicus	238-247	
32419697-13	2020	Moreover, DEX notably reduced expressions of caspase-3, caspase-9, cyt-c, and bax and increased expression of bcl-2.	Dexmedetomidine	10-13	caspase 9	Rattus norvegicus	56-65	
31308624-10	2019	In addition, DEX dose-dependently reduced apoptotic PC12 cells induced by lidocaine,as reflected by the decreased expression of apoptosis-related Bax, caspase-3 and caspase-9 and increased expression of anti-apoptotic Bcl-2 compared to the cells only treated with lidocaine.	Dexmedetomidine	13-16	caspase 9	Rattus norvegicus	165-174	
31511220-8	2019	CONCLUSIONS: Dexmedetomidine can effectively alleviate lung injury in rats during CPB possibly by targeting caspase-3 and caspase-9 proteins that are related to PI3K/Akt signaling pathway.	Dexmedetomidine	13-28	caspase 9	Rattus norvegicus	122-131	
30657579-17	2019	The mRNA expressions of HIF-1a, p-Akt, Caspase-3, and Caspase-9 in lung tissue of rats was significantly reduced after dexmedetomidine pretreatment.	Dexmedetomidine	119-134	caspase 9	Rattus norvegicus	54-63	
30250633-11	2018	Additionally, DEX downregulated the expression of Bax, cytochrome C, cleaved caspase 9, and cleaved caspase 3 proteins in mitochondria-dependent pathways.	Dexmedetomidine	14-17	caspase 9	Rattus norvegicus	77-86	
27069541-9	2016	Compared with the model group, rats given Dex had (1) shorter escape latencies, (2) more platform crossings, (3) fewer relaxin-3 and c-fos positive neurons in the hippocampal CA1 area, (4) upregulation of Bcl-2, (5) downregulation of Fas, caspase-8, and caspase-9 proteins, and (6) decreased neuroapoptosis in the hippocampus.	Dexmedetomidine	42-45	caspase 9	Rattus norvegicus	254-263	
27872485-9	2016	The DEX and ISC+DEX treatments also decreased the expression levels of caspase 3, caspase 9, and poly (ADP-ribose) polymerase in the hippocampus and DRG.	Dexmedetomidine	4-7	caspase 9	Rattus norvegicus	82-91	
27872485-9	2016	The DEX and ISC+DEX treatments also decreased the expression levels of caspase 3, caspase 9, and poly (ADP-ribose) polymerase in the hippocampus and DRG.	Dexmedetomidine	16-19	caspase 9	Rattus norvegicus	82-91