PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 35605218-0 2022 Dexmedetomidine Leads to the Mitigation of Myocardial Ischemia/Reperfusion-Induced Acute Lung Injury in Diabetic Rats Via Modulation of Hypoxia-Inducible Factor-1alpha. Dexmedetomidine 0-15 hypoxia inducible factor 1 subunit alpha Rattus norvegicus 136-167 33774474-8 2021 Concertedly, DEX reversed the impaired mitochondrial morphology in LPS stimulated-wild type mice or NC siRNA transfected NR8383 cells, upregulated the expression of mitochondrial fusion protein, while downregulated the expression of fission protein in HIF-1a/HO-1 dependent pathway. Dexmedetomidine 13-16 hypoxia inducible factor 1 subunit alpha Rattus norvegicus 252-258 33774474-9 2021 Altogether, our data both in vivo and in vitro certified that DEX treatment ameliorated endotoxin-induced acute lung injury by preserving the dynamic equilibrium of mitochondrial fusion/fission through the regulation of HIF-1a/HO-1 signaling pathway. Dexmedetomidine 62-65 hypoxia inducible factor 1 subunit alpha Rattus norvegicus 220-226 35605218-1 2022 INTRODUCTION: The objective of this study is to investigate the protective mechanism of dexmedetomidine (Dex) in myocardial ischemia/reperfusion (MIR)-induced acute lung injury (ALI) of diabetic rats by inhibiting hypoxia-inducible factor-1alpha (HIF-1alpha). Dexmedetomidine 88-103 hypoxia inducible factor 1 subunit alpha Rattus norvegicus 214-245 35605218-1 2022 INTRODUCTION: The objective of this study is to investigate the protective mechanism of dexmedetomidine (Dex) in myocardial ischemia/reperfusion (MIR)-induced acute lung injury (ALI) of diabetic rats by inhibiting hypoxia-inducible factor-1alpha (HIF-1alpha). Dexmedetomidine 88-103 hypoxia inducible factor 1 subunit alpha Rattus norvegicus 247-257 35605218-1 2022 INTRODUCTION: The objective of this study is to investigate the protective mechanism of dexmedetomidine (Dex) in myocardial ischemia/reperfusion (MIR)-induced acute lung injury (ALI) of diabetic rats by inhibiting hypoxia-inducible factor-1alpha (HIF-1alpha). Dexmedetomidine 105-108 hypoxia inducible factor 1 subunit alpha Rattus norvegicus 214-245 35605218-1 2022 INTRODUCTION: The objective of this study is to investigate the protective mechanism of dexmedetomidine (Dex) in myocardial ischemia/reperfusion (MIR)-induced acute lung injury (ALI) of diabetic rats by inhibiting hypoxia-inducible factor-1alpha (HIF-1alpha). Dexmedetomidine 105-108 hypoxia inducible factor 1 subunit alpha Rattus norvegicus 247-257 35605218-8 2022 Besides, Dex could also inhibit HIF-1alpha expression. Dexmedetomidine 9-12 hypoxia inducible factor 1 subunit alpha Rattus norvegicus 32-42 35605218-9 2022 Moreover, Dex + LV-HIF-1alpha reversed the protective role of Dex on diabetic MIR-induced ALI. Dexmedetomidine 62-65 hypoxia inducible factor 1 subunit alpha Rattus norvegicus 19-29 35605218-10 2022 CONCLUSION: Our study has made it clear that Dex inhibited the upregulation of HIF-1alpha in diabetic MIR-induced ALI, and thus protect lung functions by quenching the accumulation of oxygen radical and reducing lung inflammatory response. Dexmedetomidine 45-48 hypoxia inducible factor 1 subunit alpha Rattus norvegicus 79-89 32024386-9 2020 Furthermore, Dex prevented PC12 cells from oxidative injury through the regulation of miR-199a/HIF-1alpha. Dexmedetomidine 13-16 hypoxia inducible factor 1 subunit alpha Rattus norvegicus 95-105 32024386-0 2020 Dexmedetomidine protects PC12 cells from oxidative damage through regulation of miR-199a/HIF-1alpha. Dexmedetomidine 0-15 hypoxia inducible factor 1 subunit alpha Rattus norvegicus 89-99 32024386-7 2020 Moreover, Dex up-regulated HIF-1alpha expression via decreasing miR-199a level in PC12 cells and miR-199a targeted the 3"-UTR of HIF-1alpha. Dexmedetomidine 10-13 hypoxia inducible factor 1 subunit alpha Rattus norvegicus 27-37 32024386-7 2020 Moreover, Dex up-regulated HIF-1alpha expression via decreasing miR-199a level in PC12 cells and miR-199a targeted the 3"-UTR of HIF-1alpha. Dexmedetomidine 10-13 hypoxia inducible factor 1 subunit alpha Rattus norvegicus 129-139 31680420-0 2020 Dexmedetomidine post-treatment attenuates cardiac ischaemia/reperfusion injury by inhibiting apoptosis through HIF-1alpha signalling. Dexmedetomidine 0-15 hypoxia inducible factor 1 subunit alpha Rattus norvegicus 111-121 33336761-0 2020 Dexmedetomidine promotes the recovery of renal function and reduces the inflammatory level in renal ischemia-reperfusion injury rats through PI3K/Akt/HIF-1alpha signaling pathway. Dexmedetomidine 0-15 hypoxia inducible factor 1 subunit alpha Rattus norvegicus 150-160 33336761-1 2020 OBJECTIVE: To evaluate the protective effect of dexmedetomidine (Dex) against renal ischemia-reperfusion injury (RIRI) in rats through the phosphatidylinositol 3-hydroxy kinase (PI3K)/protein kinase B (Akt)/hypoxia-inducible factor-1alpha (HIF-1alpha) signaling pathway. Dexmedetomidine 48-63 hypoxia inducible factor 1 subunit alpha Rattus norvegicus 207-238 33336761-1 2020 OBJECTIVE: To evaluate the protective effect of dexmedetomidine (Dex) against renal ischemia-reperfusion injury (RIRI) in rats through the phosphatidylinositol 3-hydroxy kinase (PI3K)/protein kinase B (Akt)/hypoxia-inducible factor-1alpha (HIF-1alpha) signaling pathway. Dexmedetomidine 48-63 hypoxia inducible factor 1 subunit alpha Rattus norvegicus 240-250 31810122-14 2020 The diaphragmatic lipid peroxidation adducts 4-HNE and HIF-1alpha levels were significantly lower in dexmedetomidine group and propofol group compared to midazolam group (p < 0.05, respectively). Dexmedetomidine 101-116 hypoxia inducible factor 1 subunit alpha Rattus norvegicus 55-65 33336761-9 2020 CONCLUSIONS: Dex promotes the recovery of renal function and reduces the inflammatory level in RIRI rats through the PI3K/Akt/HIF-1alpha signaling pathway. Dexmedetomidine 13-16 hypoxia inducible factor 1 subunit alpha Rattus norvegicus 126-136 31680420-2 2020 This study aimed to investigate whether post-treatment with dexmedetomidine (DEX) could protect against I/R-induced cardiac apoptosis in vivo and in vitro via regulating HIF-1alpha signalling pathway. Dexmedetomidine 60-75 hypoxia inducible factor 1 subunit alpha Rattus norvegicus 170-180 31680420-2 2020 This study aimed to investigate whether post-treatment with dexmedetomidine (DEX) could protect against I/R-induced cardiac apoptosis in vivo and in vitro via regulating HIF-1alpha signalling pathway. Dexmedetomidine 77-80 hypoxia inducible factor 1 subunit alpha Rattus norvegicus 170-180 31680420-4 2020 Dexmedetomidine administration at the beginning of reperfusion or reoxygenation attenuated I/R-induced myocardial injury or H/R-induced cell death, alleviated mitochondrial dysfunction, reduced the number of apoptotic cardiomyocytes, inhibited the activation of HIF-1alpha and modulated the expressions of apoptosis-related proteins including BCL-2, BAX, BNIP3, cleaved caspase-3 and cleaved PARP. Dexmedetomidine 0-15 hypoxia inducible factor 1 subunit alpha Rattus norvegicus 262-272 31680420-5 2020 Conversely, the HIF-1alpha prolyl hydroxylase-2 inhibitor IOX2 partly blocked DEX-mediated cardioprotection both in vivo and in vitro. Dexmedetomidine 78-81 hypoxia inducible factor 1 subunit alpha Rattus norvegicus 16-26 31680420-6 2020 Mechanistically, DEX down-regulated HIF-1alpha expression at the post-transcriptional level and inhibited the transcriptional activation of the target gene BNIP3. Dexmedetomidine 17-20 hypoxia inducible factor 1 subunit alpha Rattus norvegicus 36-46 31511215-0 2019 [Dexmedetomidine hydrochloride up-regulates expression of hypoxia inducible factor-1alpha to alleviate renal ischemiareperfusion injury in diabetic rats]. Dexmedetomidine 1-30 hypoxia inducible factor 1 subunit alpha Rattus norvegicus 58-89 31260683-0 2019 Dexmedetomidine protects hippocampal neurons against hypoxia/reoxygenation-induced apoptosis through activation HIF-1alpha/p53 signaling. Dexmedetomidine 0-15 hypoxia inducible factor 1 subunit alpha Rattus norvegicus 112-122 31260683-1 2019 PURPOSE: To observe the effect of dexmedetomidine (DEX) on mitochondrial apoptosis of hippocampal neurons in hypoxia/reoxygenation (H/R) brain injury in developing rats, and to investigate its regulatory mechanism on HIF-1alpha/p53 signaling pathway. Dexmedetomidine 34-49 hypoxia inducible factor 1 subunit alpha Rattus norvegicus 217-227 31260683-1 2019 PURPOSE: To observe the effect of dexmedetomidine (DEX) on mitochondrial apoptosis of hippocampal neurons in hypoxia/reoxygenation (H/R) brain injury in developing rats, and to investigate its regulatory mechanism on HIF-1alpha/p53 signaling pathway. Dexmedetomidine 51-54 hypoxia inducible factor 1 subunit alpha Rattus norvegicus 217-227 31260683-8 2019 In addition, by adding inhibitors yohimbine and 2-methoxyestradiol (2ME2), we found that DEX could activate HIF-1alpha/p53 signaling pathway. Dexmedetomidine 89-92 hypoxia inducible factor 1 subunit alpha Rattus norvegicus 108-118 31260683-10 2019 CONCLUSION: DEX alleviates H/R-induced brain injury and mitochondrial apoptosis in developing rats through alpha2 receptor, which may be related to activation of HIF-1alpha/p53 signaling pathway to up-regulate the expression of Ngb. Dexmedetomidine 12-15 hypoxia inducible factor 1 subunit alpha Rattus norvegicus 162-172 31511215-1 2019 OBJECTIVE: To verify whether dexmedetomidine hydrochloride (Dex) alleviates renal ischemia-reperfusion (IR) injury in diabetic rats by increasing the expression of hypoxia inducible factor-1alpha (HIF-1alpha). Dexmedetomidine 60-63 hypoxia inducible factor 1 subunit alpha Rattus norvegicus 197-207 31511215-8 2019 The expressions of Scr, BUN, p-eNOS, and eNOS decreased while HIF-1alpha expression increased significantly in Dex-treated rats with renal IR injury (P &lt; 0.05). Dexmedetomidine 111-114 hypoxia inducible factor 1 subunit alpha Rattus norvegicus 62-72 31511215-10 2019 In the diabetic rats with renal IR injury, Dex treatment prior to the injury significantly lowered the expressions of Scr, BUN, p-eNOS, eNOS, cleaved caspase-3, and Bax, decreased the percentage of apoptotic cells, and increased the levels of HIF-1a and Bcl-2 (P &lt; 0.05). Dexmedetomidine 43-46 hypoxia inducible factor 1 subunit alpha Rattus norvegicus 243-249 31511215-12 2019 CONCLUSIONS: Dex alleviates renal IR injury in diabetic rats probably by inhibiting renal expression of HIF-1alpha and glomerular cell apoptosis. Dexmedetomidine 13-16 hypoxia inducible factor 1 subunit alpha Rattus norvegicus 104-114 31511215-1 2019 OBJECTIVE: To verify whether dexmedetomidine hydrochloride (Dex) alleviates renal ischemia-reperfusion (IR) injury in diabetic rats by increasing the expression of hypoxia inducible factor-1alpha (HIF-1alpha). Dexmedetomidine 29-58 hypoxia inducible factor 1 subunit alpha Rattus norvegicus 164-195 31511215-1 2019 OBJECTIVE: To verify whether dexmedetomidine hydrochloride (Dex) alleviates renal ischemia-reperfusion (IR) injury in diabetic rats by increasing the expression of hypoxia inducible factor-1alpha (HIF-1alpha). Dexmedetomidine 29-58 hypoxia inducible factor 1 subunit alpha Rattus norvegicus 197-207 31511215-1 2019 OBJECTIVE: To verify whether dexmedetomidine hydrochloride (Dex) alleviates renal ischemia-reperfusion (IR) injury in diabetic rats by increasing the expression of hypoxia inducible factor-1alpha (HIF-1alpha). Dexmedetomidine 60-63 hypoxia inducible factor 1 subunit alpha Rattus norvegicus 164-195 30657579-16 2019 In addition, dexmedetomidine pretreatment increased the expression levels of HIF-1alpha, p-Akt and HIF- in the Dex group when compared to those in the IR group. Dexmedetomidine 13-28 hypoxia inducible factor 1 subunit alpha Rattus norvegicus 77-87 31589938-0 2019 Dexmedetomidine Attenuates Lung Injury in Obstructive Jaundice Rats Through PI3K/Akt/HIF-1alpha Signaling Pathway. Dexmedetomidine 0-15 hypoxia inducible factor 1 subunit alpha Rattus norvegicus 85-95 31589938-12 2019 CONCLUSION: Dexmedetomidine can attenuate lung injury in obstructive jaundice rats through PI3K/Akt/HIF-1alpha signaling pathway. Dexmedetomidine 12-27 hypoxia inducible factor 1 subunit alpha Rattus norvegicus 100-110 30657579-17 2019 The mRNA expressions of HIF-1a, p-Akt, Caspase-3, and Caspase-9 in lung tissue of rats was significantly reduced after dexmedetomidine pretreatment. Dexmedetomidine 119-134 hypoxia inducible factor 1 subunit alpha Rattus norvegicus 24-30 22150679-9 2012 The proteins of HIF-1alpha, VEGF and RTP801 were significantly increased by dexmedetomidine treatment. Dexmedetomidine 76-91 hypoxia inducible factor 1 subunit alpha Rattus norvegicus 16-26 27412350-0 2016 Dexmedetomidine protects against lung ischemia-reperfusion injury by the PI3K/Akt/HIF-1alpha signaling pathway. Dexmedetomidine 0-15 hypoxia inducible factor 1 subunit alpha Rattus norvegicus 82-92 27412350-1 2016 PURPOSE: To evaluate the role of the phosphatidylinositol 3 kinase (PI3K)/protein kinase B (Akt)/hypoxia-inducible factor 1alpha (HIF-1alpha) signaling pathway in the protection by dexmedetomidine against lung ischemia-reperfusion injury (IRI) in rats. Dexmedetomidine 181-196 hypoxia inducible factor 1 subunit alpha Rattus norvegicus 97-128 27412350-1 2016 PURPOSE: To evaluate the role of the phosphatidylinositol 3 kinase (PI3K)/protein kinase B (Akt)/hypoxia-inducible factor 1alpha (HIF-1alpha) signaling pathway in the protection by dexmedetomidine against lung ischemia-reperfusion injury (IRI) in rats. Dexmedetomidine 181-196 hypoxia inducible factor 1 subunit alpha Rattus norvegicus 130-140 27412350-8 2016 CONCLUSIONS: Administration of dexmedetomidine before ischemia can provide a protection against lung IRI by re-installing the PI3K/Akt/HIF-1alpha signaling pathway. Dexmedetomidine 31-46 hypoxia inducible factor 1 subunit alpha Rattus norvegicus 135-145 30456861-0 2018 Dexmedetomidine alleviates cerebral ischemia-reperfusion injury in rats via inhibition of hypoxia-inducible factor-1alpha. Dexmedetomidine 0-15 hypoxia inducible factor 1 subunit alpha Rattus norvegicus 90-121 30456861-2 2018 Thus, we aimed to study the role and mechanism of Dex in cerebral I/R injury by inhibiting hypoxia-inducible factor-1alpha (HIF-1alpha) and apoptosis. Dexmedetomidine 50-53 hypoxia inducible factor 1 subunit alpha Rattus norvegicus 91-122 30456861-2 2018 Thus, we aimed to study the role and mechanism of Dex in cerebral I/R injury by inhibiting hypoxia-inducible factor-1alpha (HIF-1alpha) and apoptosis. Dexmedetomidine 50-53 hypoxia inducible factor 1 subunit alpha Rattus norvegicus 124-134 30456861-9 2018 Furthermore, activation of HIF-1alpha expression blocks the inhibitory effect of Dex on neuronal apoptosis in I/R rats. Dexmedetomidine 81-84 hypoxia inducible factor 1 subunit alpha Rattus norvegicus 27-37 30456861-10 2018 Dex may inhibit the neuronal apoptosis of I/R rats by inhibiting the HIF-1alpha pathway and then improve the cerebral I/R injury in rats. Dexmedetomidine 0-3 hypoxia inducible factor 1 subunit alpha Rattus norvegicus 69-79 25565380-12 2016 Dexmedetomidine preconditioning also elevated HIF-1alpha and VEGF expression after global cerebral ischemia following asphyxial CA. Dexmedetomidine 0-15 hypoxia inducible factor 1 subunit alpha Rattus norvegicus 46-56 25565380-13 2016 CONCLUSION: Dexmedetomidine preconditioning protected against cerebral ischemic injury and was associated with upregulation of HIF-1alpha and VEGF expression. Dexmedetomidine 12-27 hypoxia inducible factor 1 subunit alpha Rattus norvegicus 127-137 22150679-10 2012 CONCLUSIONS: Dexmedetomidine activated the I2 imidazoline receptor-PI3K/AKT pathway, and up-regulated HIF-1alpha, VEGF and RTP801 expression to protect against OGD-induced injury in rat C6 cells. Dexmedetomidine 13-28 hypoxia inducible factor 1 subunit alpha Rattus norvegicus 102-112