PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
29960167-0	2018	Dexmedetomidine protects against lipopolysaccharide-induced sepsis-associated acute kidney injury via an alpha7 nAChR-dependent pathway.	Dexmedetomidine	0-15	cholinergic receptor, nicotinic, alpha polypeptide 7	Mus musculus	105-117	
29960167-9	2018	Furthermore, the protective role of DEX was markedly inhibited by the alpha7 nicotinic acetylcholine receptor (nAChR) antagonist alpha-bungarotoxin.	Dexmedetomidine	36-39	cholinergic receptor, nicotinic, alpha polypeptide 7	Mus musculus	111-116	
29960167-10	2018	These findings provided novel evidence for the anti-apoptotic and anti-inflammatory effects of DEX in LPS-induced AKI mice through an alpha7 nAChR-dependent signaling pathway.	Dexmedetomidine	95-98	cholinergic receptor, nicotinic, alpha polypeptide 7	Mus musculus	134-146	
26911944-0	2016	[Role of alpha7 nicotinic acetylcholine receptor in attenuation of endotoxin induced delirium with dexmedetomidine in mice].	Dexmedetomidine	99-114	cholinergic receptor, nicotinic, alpha polypeptide 7	Mus musculus	9-48	
26911944-1	2016	OBJECTIVE: To observe the role of alpha7 nicotinic acetylcholine receptor (alpha7nAChR) in the protection against delirium by the use of dexmedetomidine (DEX) in endotoxin derived delirium and its mechanism.	Dexmedetomidine	137-152	cholinergic receptor, nicotinic, alpha polypeptide 7	Mus musculus	34-73	
26911944-1	2016	OBJECTIVE: To observe the role of alpha7 nicotinic acetylcholine receptor (alpha7nAChR) in the protection against delirium by the use of dexmedetomidine (DEX) in endotoxin derived delirium and its mechanism.	Dexmedetomidine	137-152	cholinergic receptor, nicotinic, alpha polypeptide 7	Mus musculus	75-86	
26911944-1	2016	OBJECTIVE: To observe the role of alpha7 nicotinic acetylcholine receptor (alpha7nAChR) in the protection against delirium by the use of dexmedetomidine (DEX) in endotoxin derived delirium and its mechanism.	Dexmedetomidine	154-157	cholinergic receptor, nicotinic, alpha polypeptide 7	Mus musculus	34-73	
26911944-1	2016	OBJECTIVE: To observe the role of alpha7 nicotinic acetylcholine receptor (alpha7nAChR) in the protection against delirium by the use of dexmedetomidine (DEX) in endotoxin derived delirium and its mechanism.	Dexmedetomidine	154-157	cholinergic receptor, nicotinic, alpha polypeptide 7	Mus musculus	75-86	
26911944-5	2016	The mice in alpha-BGT+DEX+LPS group were intraperitoneally injected with alpha7nAChR inhibitor alpha-BGT 1 mug/kg 15 minutes before DEX injection.	Dexmedetomidine	22-25	cholinergic receptor, nicotinic, alpha polypeptide 7	Mus musculus	73-84	
26911944-23	2016	DEX could attenuate endotoxemia-associated delirium syndrome through transforming central neurotransmitter, and its mechanism maybe related with alpha7nAChR.	Dexmedetomidine	0-3	cholinergic receptor, nicotinic, alpha polypeptide 7	Mus musculus	145-156	
33141376-10	2021	Splenectomy inhibited dexmedetomidine-mediated activation of the alpha7nAChR pathway.	Dexmedetomidine	22-37	cholinergic receptor, nicotinic, alpha polypeptide 7	Mus musculus	65-76	
27074053-10	2016	The overall results demonstrate that Dex inhibits the LPS-induced inflammatory reaction in the lung tissues of septic mice partly through the alpha7nAChR-dependent cholinergic anti-inflammatory pathway.	Dexmedetomidine	37-40	cholinergic receptor, nicotinic, alpha polypeptide 7	Mus musculus	142-153	
26702389-2	2015	The protective effects of Dex may reportedly be due to the activation of the alpha7 nicotinic acetylcholine receptor (alpha7nAChR)-dependent cholinergic anti-inflammatory pathway.	Dexmedetomidine	26-29	cholinergic receptor, nicotinic, alpha polypeptide 7	Mus musculus	77-116	
26702389-2	2015	The protective effects of Dex may reportedly be due to the activation of the alpha7 nicotinic acetylcholine receptor (alpha7nAChR)-dependent cholinergic anti-inflammatory pathway.	Dexmedetomidine	26-29	cholinergic receptor, nicotinic, alpha polypeptide 7	Mus musculus	118-129	
26702389-8	2015	Conversely, preemptive injection of alpha-bungarotoxin, a selective alpha7nAChR antagonist, reversed these effects of Dex.	Dexmedetomidine	118-121	cholinergic receptor, nicotinic, alpha polypeptide 7	Mus musculus	68-79	
24803295-15	2014	These findings show that central alpha-2 agonist dexmedetomidine suppresses systemic inflammation through vagal- and alpha7nAChR-dependent mechanism.	Dexmedetomidine	49-64	cholinergic receptor, nicotinic, alpha polypeptide 7	Mus musculus	117-128