PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
33821300-6	2021	DEX also markedly attenuated the increases in malondialdehyde 5 (MDA 5) and inositol-dependent enzyme a (IRE-a), attenuated the decrease in superoxide dismutase 1(SOD-1), reversed the low expression of B-cell lymphoma-2 (Bcl-2), and the high expressions of Bax and Caspase-3.	Dexmedetomidine	0-3	BCL2-associated X protein	Mus musculus	257-260	
35434046-9	2022	Of note, dexmedetomidine suppressed LIR-induced lung tissue apoptosis by modulating apoptosis-associated protein such as Bax, Bcl-2, and cleaved caspase 3.	Dexmedetomidine	9-24	BCL2-associated X protein	Mus musculus	121-124	
33782744-10	2021	At the same time, it was observed that DEX improved the Bcl-2/Bax ratio.	Dexmedetomidine	39-42	BCL2-associated X protein	Mus musculus	62-65	
34159456-10	2021	In addition, Dex remarkably reduced the surgery-induced increased ratio of Bax/Bcl-2 and apoptotic neurons in the hippocampi of aged mice.	Dexmedetomidine	13-16	BCL2-associated X protein	Mus musculus	75-78	
35528513-7	2022	Our results showed that Dex (50 mug/kg) most significantly attenuated MPTP-induced motor dysfunction and restored TH-positive neurons in the SN, increased the expression of the antiapoptotic protein Bcl-2, and decreased the expression of apoptotic proteins cleaved casepase3, cleaved casepase9, and Bax.	Dexmedetomidine	24-27	BCL2-associated X protein	Mus musculus	299-302	
31643023-8	2020	Moreover, the expression of anti-apoptotic protein Bcl-2 was increased, whereas the expression of pro-apoptotic protein Bax was decreased by Dex.	Dexmedetomidine	141-144	BCL2-associated X protein	Mus musculus	120-123	
31927655-11	2020	In addition, DEX dramatically prevented sepsis-induced pulmonary cell apoptosis in mice, as reflected by decreases in the number of TUNEL-positive cells, the protein expression of cleaved caspase-9 and cleaved caspase 3 and the Bax/Bcl-2 ratio.	Dexmedetomidine	13-16	BCL2-associated X protein	Mus musculus	228-231	
28709158-10	2017	The results showed that DEX decreased TUNEL-positive cells induced by heatstroke in a Bax/Bcl-2-related manner.	Dexmedetomidine	24-27	BCL2-associated X protein	Mus musculus	86-89	
27987330-6	2017	As to the mechanisms, exposure of neuro-2a cells to dexmedetomidine substantially attenuated I/R-induced translocation of Bax protein from the cytosol to mitochondria and reduction in the mitochondrial membrane potential (MMP).	Dexmedetomidine	52-67	BCL2-associated X protein	Mus musculus	122-125	
27987330-10	2017	Taken together, this study has shown the neuroprotective effects of dexmedetomidine against I/R-induced apoptotic insults via an intrinsic Bax-mitochondria-cytochrome c-caspase protease pathway.	Dexmedetomidine	68-83	BCL2-associated X protein	Mus musculus	139-142	
29566706-20	2018	Dexmedetomidine increased p-Akt in a time- and dose-dependent manner, and down-regulated the expression of caspase 3 and Bax and up-regulated the Bcl-2 expression in PMVECs.	Dexmedetomidine	0-15	BCL2-associated X protein	Mus musculus	121-124	
28224201-10	2017	Mice treated with DEX exhibited less apoptotic tubular cells in response to cisplatin insult, which was associated with decreased Bax and reduced activation of p53 and caspase-3.	Dexmedetomidine	18-21	BCL2-associated X protein	Mus musculus	130-133	
26683659-8	2016	Dexmedetomidine pretreatment effectively improved histological outcome and restored levels of caspase-3, the Bax/Bcl-2 ratio, NF-kappaB, and COX-2.	Dexmedetomidine	0-15	BCL2-associated X protein	Mus musculus	109-112	
28173746-11	2017	The associated results also demonstrated that Dex treatment ameliorated the LPS-induced neuronal apoptosis, probably by upregulating the Bcl-2 expression and downregulating the Bax expression.	Dexmedetomidine	46-49	BCL2-associated X protein	Mus musculus	177-180