PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 34237977-12 2021 Dex can alleviate cerebral CI/RI in rats by increasing alpha2-adrenergic receptor and blocking JNK phosphorylation and activation of caspase-3. Dexmedetomidine 0-3 mitogen-activated protein kinase 8 Rattus norvegicus 95-98 34237977-0 2021 Dexmedetomidine attenuates cerebral ischemia-reperfusion injury in rats by inhibiting the JNK pathway. Dexmedetomidine 0-15 mitogen-activated protein kinase 8 Rattus norvegicus 90-93 34237977-2 2021 This study was conducted to explore the effects of dexmedetomidine (Dex) on the c-Jun N-terminal kinase (JNK) pathway in CI/RI, and to provide a theoretical basis for the recovery of brain function after cerebral ischemia. Dexmedetomidine 51-66 mitogen-activated protein kinase 8 Rattus norvegicus 80-103 34237977-2 2021 This study was conducted to explore the effects of dexmedetomidine (Dex) on the c-Jun N-terminal kinase (JNK) pathway in CI/RI, and to provide a theoretical basis for the recovery of brain function after cerebral ischemia. Dexmedetomidine 68-71 mitogen-activated protein kinase 8 Rattus norvegicus 80-103 34237977-7 2021 RESULTS: Compared with the Sham group, the rats in I/R, I/R + Dex, I/R + Yoh + Dex, and I/R + SP600125 groups developed hemiparesis of the left forelimb at different levels with a higher neurological deficit score, brain water content, infarct volume, and markedly upregulated expression of cleaved caspase-3, p-JNK (P<0.05). Dexmedetomidine 62-65 mitogen-activated protein kinase 8 Rattus norvegicus 312-315 34237977-7 2021 RESULTS: Compared with the Sham group, the rats in I/R, I/R + Dex, I/R + Yoh + Dex, and I/R + SP600125 groups developed hemiparesis of the left forelimb at different levels with a higher neurological deficit score, brain water content, infarct volume, and markedly upregulated expression of cleaved caspase-3, p-JNK (P<0.05). Dexmedetomidine 79-82 mitogen-activated protein kinase 8 Rattus norvegicus 312-315 35457136-7 2022 Dexmedetomidine-induced EGFR tyrosine and JNK phosphorylation were inhibited by rauwolscine, PP1, PP2, GM6001, and AG1478. Dexmedetomidine 0-15 mitogen-activated protein kinase 8 Rattus norvegicus 42-45 35457136-8 2022 Furthermore, dexmedetomidine-induced JNK phosphorylation reduced upon EGFR siRNA treatment. Dexmedetomidine 13-28 mitogen-activated protein kinase 8 Rattus norvegicus 37-40 35457136-9 2022 Therefore, these results suggested that the transactivation of EGFR associated with dexmedetomidine-induced contraction, mediated by the alpha-2 adrenoceptor, Src kinase, and matrix metalloproteinase, caused JNK phosphorylation and increased calcium levels. Dexmedetomidine 84-99 mitogen-activated protein kinase 8 Rattus norvegicus 208-211 35527005-0 2022 Dexmedetomidine attenuates acute stress-induced liver injury in rats by regulating the miR-34a-5p/ROS/JNK/p38 signaling pathway. Dexmedetomidine 0-15 mitogen-activated protein kinase 8 Rattus norvegicus 102-105 35527005-12 2022 Collectively, DEX could alleviate acute stress-induced liver injury through ROS/JNK/p38 signaling pathway via downregulation of miR-34a-5p. Dexmedetomidine 14-17 mitogen-activated protein kinase 8 Rattus norvegicus 80-83 31446520-0 2019 Role of JNK Signaling Pathway in Dexmedetomidine Post-Conditioning-Induced Reduction of the Inflammatory Response and Autophagy Effect of Focal Cerebral Ischemia Reperfusion Injury in Rats. Dexmedetomidine 33-48 mitogen-activated protein kinase 8 Rattus norvegicus 8-11 32451082-8 2020 The dexmedetomidine-induced TNF-alpha mRNA increase was accompanied by phosphorylation of JNK and ERK, which was blocked by a JNK inhibitor. Dexmedetomidine 4-19 mitogen-activated protein kinase 8 Rattus norvegicus 90-93 32451082-8 2020 The dexmedetomidine-induced TNF-alpha mRNA increase was accompanied by phosphorylation of JNK and ERK, which was blocked by a JNK inhibitor. Dexmedetomidine 4-19 mitogen-activated protein kinase 8 Rattus norvegicus 126-129 31999428-0 2020 Dexmedetomidine alleviates neurogenesis damage following neonatal midazolam exposure in rats through JNK and P38 MAPK pathways. Dexmedetomidine 0-15 mitogen-activated protein kinase 8 Rattus norvegicus 101-104 31999428-15 2020 These results indicate that dexmedetomidine alleviated midazolam-induced neurogenesis damage via JNK and P38 MAPK pathways. Dexmedetomidine 28-43 mitogen-activated protein kinase 8 Rattus norvegicus 97-100 31446520-9 2019 However, the protective effect of dexmedetomidine on brain injury in MCAO rats was reversed by JNK pathway activator. Dexmedetomidine 34-49 mitogen-activated protein kinase 8 Rattus norvegicus 95-98 31682592-8 2019 Dexmedetomidine induced GRP78 expression but inhibited CHOP, Caspase-3 and phosphorylated-JNK expression in brain tissues. Dexmedetomidine 0-15 mitogen-activated protein kinase 8 Rattus norvegicus 90-93 30250633-0 2018 Dexmedetomidine Ameliorates Acute Stress-Induced Kidney Injury by Attenuating Oxidative Stress and Apoptosis through Inhibition of the ROS/JNK Signaling Pathway. Dexmedetomidine 0-15 mitogen-activated protein kinase 8 Rattus norvegicus 139-142 30618065-9 2019 DEX treatment also effectively inhibited acute stress-induced c-Jun N-terminal kinase (JNK), P38, and BAD signaling pathway activation, and significantly induced MKP-1 activation. Dexmedetomidine 0-3 mitogen-activated protein kinase 8 Rattus norvegicus 62-85 30618065-9 2019 DEX treatment also effectively inhibited acute stress-induced c-Jun N-terminal kinase (JNK), P38, and BAD signaling pathway activation, and significantly induced MKP-1 activation. Dexmedetomidine 0-3 mitogen-activated protein kinase 8 Rattus norvegicus 87-90 30250633-10 2018 DEX also inhibited the release of norepinephrine (NE), decreased the production of reactive oxygen species (ROS), and inhibited JNK phosphorylation. Dexmedetomidine 0-3 mitogen-activated protein kinase 8 Rattus norvegicus 128-131 30250633-12 2018 In summary, DEX protects against acute stress-induced kidney injury in rats by reducing oxidative stress and apoptosis via inhibition of the ROS/JNK pathway. Dexmedetomidine 12-15 mitogen-activated protein kinase 8 Rattus norvegicus 145-148 25224579-1 2014 Vasoconstriction induced by dexmedetomidine, a highly selective alpha-2 adrenoceptor agonist, mainly involves c-Jun NH2 -terminal kinase (JNK) phosphorylation in the isolated endothelium-denuded aorta. Dexmedetomidine 28-43 mitogen-activated protein kinase 8 Rattus norvegicus 138-141 26392810-11 2015 Dexmedetomidine also induced JNK phosphorylation, which was inhibited by rottlerin. Dexmedetomidine 0-15 mitogen-activated protein kinase 8 Rattus norvegicus 29-32 26392810-12 2015 Taken together, these results suggest that the dexmedetomidine-induced contraction involves PKC-delta-dependent JNK phosphorylation in the isolated rat aorta. Dexmedetomidine 47-62 mitogen-activated protein kinase 8 Rattus norvegicus 112-115 26392810-0 2015 Dexmedetomidine-Induced Contraction in the Isolated Endothelium-Denuded Rat Aorta Involves PKC-delta-mediated JNK Phosphorylation. Dexmedetomidine 0-15 mitogen-activated protein kinase 8 Rattus norvegicus 110-113 25224579-2 2014 We carried out an in vitro study to determine the main arachidonic acid metabolic pathway that is involved in dexmedetomidine-induced JNK activation. Dexmedetomidine 110-125 mitogen-activated protein kinase 8 Rattus norvegicus 134-137 25224579-9 2014 SP600125, rauwolscine, quinacrine dihydrochloride, nordihydroguaiaretic acid, AA-861, phenidone and GF 109203X attenuated dexmedetomidine-induced JNK phosphorylation. Dexmedetomidine 122-137 mitogen-activated protein kinase 8 Rattus norvegicus 146-149 25224579-11 2014 Thus, dexmedetomidine-induced alpha-2 adrenoceptor-mediated contraction is mediated mainly by 5-LOX and partially by COX-2, which leads to JNK phosphorylation. Dexmedetomidine 6-21 mitogen-activated protein kinase 8 Rattus norvegicus 139-142 25332685-0 2014 Dexmedetomidine-induced contraction involves phosphorylation of caldesmon by JNK in endothelium-denuded rat aortas. Dexmedetomidine 0-15 mitogen-activated protein kinase 8 Rattus norvegicus 77-80 25332685-7 2014 The effects of GF109203X (a PKC inhibitor) on DMT- or PDBu-induced JNK phosphorylation in VSMCs were assessed. Dexmedetomidine 46-49 mitogen-activated protein kinase 8 Rattus norvegicus 67-70 25332685-11 2014 Additionally, PDBu induced caldesmon phosphorylation, and GF109203X attenuated the JNK phosphorylation induced by DMT or PDBu. Dexmedetomidine 114-117 mitogen-activated protein kinase 8 Rattus norvegicus 83-86 25332685-13 2014 These results suggest that alpha-2 adrenoceptor-mediated, DMT-induced contraction involves caldesmon phosphorylation that is mediated by JNK phosphorylation by PKC. Dexmedetomidine 58-61 mitogen-activated protein kinase 8 Rattus norvegicus 137-140 25026397-0 2014 Both JNK and P38 MAPK pathways participate in the protection by dexmedetomidine against isoflurane-induced neuroapoptosis in the hippocampus of neonatal rats. Dexmedetomidine 64-79 mitogen-activated protein kinase 8 Rattus norvegicus 5-8 25026397-12 2014 Our results indicate that the JNK and p38 pathways, not the ERK pathway are involved in dexmedetomidine-induced neuroprotection against isoflurane effects. Dexmedetomidine 88-103 mitogen-activated protein kinase 8 Rattus norvegicus 30-33 21488184-6 2011 Dexmedetomidine-induced phosphorylation of ERK, JNK, and p38 MAPK in rat aortic SMCs was detected using Western blotting. Dexmedetomidine 0-15 mitogen-activated protein kinase 8 Rattus norvegicus 48-51 21488184-10 2011 Dexmedetomidine induced phosphorylation of JNK and p38 MAPK in rat aortic SMCs, but did not induce phosphorylation of ERK. Dexmedetomidine 0-15 mitogen-activated protein kinase 8 Rattus norvegicus 43-46 21488184-11 2011 CONCLUSION: Dexmedetomidine-induced contraction involves a JNK- and p38 MAPK-mediated pathway downstream of alpha2-adrenoceptor stimulation in rat aortic SMCs. Dexmedetomidine 12-27 mitogen-activated protein kinase 8 Rattus norvegicus 59-62 21488184-0 2011 c-Jun NH2-terminal kinase contributes to dexmedetomidine-induced contraction in isolated rat aortic smooth muscle. Dexmedetomidine 41-56 mitogen-activated protein kinase 8 Rattus norvegicus 0-25