PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 22477202-0 2012 Ursolic acid-induced apoptosis in K562 cells involving upregulation of PTEN gene expression and inactivation of the PI3K/Akt pathway. ursolic acid 0-12 phosphatase and tensin homolog Homo sapiens 71-75 24762997-1 2014 The study was aimed to investigate the inducing effect of ursolic acid (UA) on the apoptosis of human T-cell leukemia/lymphoma (Jurkat), and whether the regulation of PTEN involved in the effect of UA on Jurkat cells. ursolic acid 198-200 phosphatase and tensin homolog Homo sapiens 167-171 24762997-9 2014 It is concluded that UA may induce Jurkat cell apoptosis by up-regulating the PTEN mRNA expression. ursolic acid 21-23 phosphatase and tensin homolog Homo sapiens 78-82 25520072-0 2014 Ursolic acid promotes apoptosis of SGC-7901 gastric cancer cells through ROCK/PTEN mediated mitochondrial translocation of cofilin-1. ursolic acid 0-12 phosphatase and tensin homolog Homo sapiens 78-82 25520072-5 2014 Further mechanistic studies revealed that the ROCK1/PTEN signaling pathway plays a critical role in UA-mediated mitochondrial translocation of cofilin-1 and apoptosis. ursolic acid 100-102 phosphatase and tensin homolog Homo sapiens 52-56 25520072-6 2014 These findings imply that induction of apoptosis by ursolic acid stems primarily from the activation of ROCK1 and PTEN, resulting in the translocation of cofilin-1 from cytoplasm to mitochondria, release of cytochrome c, activation of caspase-3 and caspase-9, and finally inducing apoptosis of gastric cancer SGC-7901 cells. ursolic acid 52-64 phosphatase and tensin homolog Homo sapiens 114-118 22477202-4 2012 Here, we demonstrated that UA was able to inhibit growth, induce apoptosis in a human chronic myelogenous leukemia cell line (K562 cells) via upregulation of PTEN gene expression, inhibit Akt kinase activity, change mitochondrial transmembrane potential and reduce the release of cytochrome c and the activity of caspases. ursolic acid 27-29 phosphatase and tensin homolog Homo sapiens 158-162 22477202-5 2012 These results suggest that UA may elicit its strong antitumor effects via upregulation of the PTEN gene and inhibition of the PI3K/Akt pathway. ursolic acid 27-29 phosphatase and tensin homolog Homo sapiens 94-98 27698874-9 2016 The results of the present study indicate that the anticancer effect of ursolic acid activates cell apoptosis through ROCK/PTEN mediated mitochondrial translocation of cofilin-1 in prostate cancer. ursolic acid 72-84 phosphatase and tensin homolog Homo sapiens 123-127 29595211-0 2018 Correction: A smart pH-responsive nano-carrier as a drug delivery system for the targeted delivery of ursolic acid: suppresses cancer growth and metastasis by modulating P53/MMP-9/PTEN/CD44 mediated multiple signaling pathways. ursolic acid 102-114 phosphatase and tensin homolog Homo sapiens 180-184 29595211-1 2018 Correction for "A smart pH-responsive nano-carrier as a drug delivery system for the targeted delivery of ursolic acid: suppresses cancer growth and metastasis by modulating P53/MMP-9/PTEN/CD44 mediated multiple signaling pathways" by Kai Jiang et al., Nanoscale, 2017, 9, 9428-9439. ursolic acid 106-118 phosphatase and tensin homolog Homo sapiens 184-188 29435058-0 2018 Ursolic acid activates the apoptosis of prostate cancer via ROCK/PTEN mediated mitochondrial translocation of cofilin-1. ursolic acid 0-12 phosphatase and tensin homolog Homo sapiens 65-69 29435058-3 2018 The aim of the present study was to assess whether ursolic acid activates the apoptosis of prostate cancer and to investigate the mechanism by which the Rho-associated protein kinase 1 (ROCK1)/phosphatase and tensin homolog (PTEN) signaling pathway performs a role in ursolic acid-mediated cofilin-1 to induce apoptosis in human prostate cancer. ursolic acid 51-63 phosphatase and tensin homolog Homo sapiens 225-229 29435058-3 2018 The aim of the present study was to assess whether ursolic acid activates the apoptosis of prostate cancer and to investigate the mechanism by which the Rho-associated protein kinase 1 (ROCK1)/phosphatase and tensin homolog (PTEN) signaling pathway performs a role in ursolic acid-mediated cofilin-1 to induce apoptosis in human prostate cancer. ursolic acid 268-280 phosphatase and tensin homolog Homo sapiens 225-229 29435058-8 2018 In conclusion, these findings demonstrated that ursolic acid activates the apoptosis of prostate cancer via ROCK/PTEN mediated cofilin-1/cytochrome c which mediated caspase-3/9 activities. ursolic acid 48-60 phosphatase and tensin homolog Homo sapiens 113-117 27698874-0 2016 Anti-cancer effect of ursolic acid activates apoptosis through ROCK/PTEN mediated mitochondrial translocation of cofilin-1 in prostate cancer. ursolic acid 22-34 phosphatase and tensin homolog Homo sapiens 68-72 27698874-8 2016 Ursolic acid significantly suppressed the ROCK/PTEN signaling pathway and inhibited cofilin-1 protein expression in DU145 cells. ursolic acid 0-12 phosphatase and tensin homolog Homo sapiens 47-51 23600297-0 2012 [Ursolic acid as antitumor agent and inductor of PTEN and brown fat]. ursolic acid 1-13 phosphatase and tensin homolog Homo sapiens 49-53 23600297-2 2012 Beside inhibiting tumor cell growth in vitro and in vivo and activating of apoptosis, UA (as well as some other related and not related compounds) is capable to induce PTEN (a tumor suppressor mutation of which is rather often discovered in human tumors including endometrial cancer type I) and amount/activity of brown fat. ursolic acid 86-88 phosphatase and tensin homolog Homo sapiens 168-172 28660943-0 2017 A smart pH-responsive nano-carrier as a drug delivery system for the targeted delivery of ursolic acid: suppresses cancer growth and metastasis by modulating P53/MMP-9/PTEN/CD44 mediated multiple signaling pathways. ursolic acid 90-102 phosphatase and tensin homolog Homo sapiens 168-172 28660943-7 2017 Mechanistically, UA@M-CS-FA induced cancer cell apoptosis and inhibited migration via cell cycle arrest in the G0/G1 stage, regulating the PARP/Bcl-2/MMP-9/CD44/PTEN/P53. ursolic acid 17-19 phosphatase and tensin homolog Homo sapiens 161-165