PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
17855663-9	2007	Ursolic acid down-regulated the expression of STAT3-regulated gene products such as cyclin D1, Bcl-2, Bcl-xL, survivin, Mcl-1, and vascular endothelial growth factor.	ursolic acid	0-12	cyclin D1	Homo sapiens	84-93	
15350828-4	2004	The results showed that UA blocked cell cycle progression in the G1 phase that was associated with a marked decrease in the protein expression of cyclin D1, D2, and E and their activating partner cdk2, 4, and 6 with concomitant induction of p21/WAF1.	ursolic acid	24-26	cyclin D1	Homo sapiens	146-155	
34584036-6	2021	We identified ursolic acid in MRBE through LC/mass spectrum (MS) and observed that it also decreased intracellular beta-catenin, c-myc, and cyclin D1 levels.	ursolic acid	14-26	cyclin D1	Homo sapiens	140-149	
12907607-0	2003	Ursolic acid inhibits nuclear factor-kappaB activation induced by carcinogenic agents through suppression of IkappaBalpha kinase and p65 phosphorylation: correlation with down-regulation of cyclooxygenase 2, matrix metalloproteinase 9, and cyclin D1.	ursolic acid	0-12	cyclin D1	Homo sapiens	240-249	
30214619-9	2018	Mechanistically, RME and UA inhibited G1-S phase transition resulting in an increased G1:S+G2/M ratio and decreased cyclin D1 expression.	ursolic acid	25-27	cyclin D1	Homo sapiens	116-125	
29798594-11	2017	Conclusion: Ursolic acid can effectively inhibit the proliferation of osteosarcoma cell line U2-OS, induce the down-regulation of cyclin D1 expression leading to G 0/G 1 phase arrest, increase the activation of Caspase-3 and promote cell apoptosis.	ursolic acid	12-24	cyclin D1	Homo sapiens	130-139	
27665868-10	2016	Moreover, inhibition of p53 partly reverses the UA-induced downregulation of beta-catenin, as do the targets of Wnt/beta-catenin signaling, such as c-Myc and cyclin D1.	ursolic acid	48-50	cyclin D1	Homo sapiens	158-167	
28090191-4	2016	Also, ursolic acid treatment accumulated the sub-G1 population, attenuated the expression of procapase 9, cyclin D1, pAKT, p-glycogen synthase kinase 3-alpha/beta (pGSK3alpha/beta), beta-catenin and nuclear factor kappa-light-chain-enhancer of activated B cells (NFkB) and also cleaved caspase 3 and poly (ADP-ribose) polymerase (PARP) in mesothelioma cells.	ursolic acid	6-18	cyclin D1	Homo sapiens	106-115	
24083669-0	2013	Effect of ursolic acid on MAPK in cyclin D1 signaling and RING-type E3 ligase (SCF E3s) in two endometrial cancer cell lines.	ursolic acid	10-22	cyclin D1	Homo sapiens	34-43	
24083669-5	2013	Ursolic acid (UA) treatment of SNG-2 cells, an endometrial cancer cell line, decreased cyclin D1, pERK1/2, FBXW8, and Cullin1 levels in a dose- and time-dependent manner.	ursolic acid	0-12	cyclin D1	Homo sapiens	87-96	
24083669-5	2013	Ursolic acid (UA) treatment of SNG-2 cells, an endometrial cancer cell line, decreased cyclin D1, pERK1/2, FBXW8, and Cullin1 levels in a dose- and time-dependent manner.	ursolic acid	14-16	cyclin D1	Homo sapiens	87-96	
21191671-4	2012	After treatment, UA-induced apoptosis was accompanied by a significant decrease in CyclinD1/CDK4 expression, which can be regulated by FoxM1.	ursolic acid	17-19	cyclin D1	Homo sapiens	83-91	
21191671-7	2012	Taken together, the data suggest that the proapoptotic effect of UA on MCF-7 cells is mediated by inhibition of FoxM1 and is highly correlated with inactivation of CyclinD1/CDK4.	ursolic acid	65-67	cyclin D1	Homo sapiens	164-172