PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 23584398-0 2013 Ezrin dephosphorylation/downregulation contributes to ursolic acid-mediated cell death in human leukemia cells. ursolic acid 54-66 ezrin Homo sapiens 0-5 23584398-6 2013 Knockdown of ezrin enhanced cell death mediated by UA, whereas overexpression of ezrin attenuated UA-induced apoptosis. ursolic acid 98-100 ezrin Homo sapiens 81-86 23584398-8 2013 Such findings suggest that the cytoskeletal protein ezrin may represent an attractive target for UA-mediated lethality in human leukemia cells. ursolic acid 97-99 ezrin Homo sapiens 52-57 23584398-3 2013 However, the exact role of ezrin in ursolic acid (UA)-induced apoptosis remains unclear. ursolic acid 36-48 ezrin Homo sapiens 27-32 23584398-4 2013 In this study, we show for the first time that UA induces apoptosis in both transformed and primary leukemia cells through dephosphorylation/downregulation of ezrin, association and polarized colocalization of Fas and ezrin, as well as formation of death-inducing signaling complex. ursolic acid 47-49 ezrin Homo sapiens 159-164 23584398-4 2013 In this study, we show for the first time that UA induces apoptosis in both transformed and primary leukemia cells through dephosphorylation/downregulation of ezrin, association and polarized colocalization of Fas and ezrin, as well as formation of death-inducing signaling complex. ursolic acid 47-49 ezrin Homo sapiens 218-223 23584398-6 2013 Knockdown of ezrin enhanced cell death mediated by UA, whereas overexpression of ezrin attenuated UA-induced apoptosis. ursolic acid 51-53 ezrin Homo sapiens 13-18