PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 34512368-3 2021 In this review, we focus on summarizing some representative natural active compounds, mainly including curcumin, resveratrol, paclitaxel, Bufalin, and Ursolic acid that may ultimately trigger cancer cell death through the regulation of some key autophagic signaling pathways, such as RAS-RAF-MEK-ERK, PI3K-AKT-mTOR, AMPK, ULK1, Beclin-1, Atg5 and p53. ursolic acid 151-163 tumor protein p53 Homo sapiens 347-350 32617130-5 2020 UA pretreatment of HDFs also attenuated the UVB-induced expression of inflammatory (TNF-alpha and NF-kappaB) and apoptotic (p53, Bax, and caspase-3) and MMPs (MMP-2 and MMP-9) and enhanced the Bcl-2 protein levels in 20 muM UA treatment, when compared to concentrations. ursolic acid 0-2 tumor protein p53 Homo sapiens 124-127 34141150-6 2021 Ursolic acid treatment downregulated the gene expression of survival factors BCL-2, SURVIVIN, NFKB and SP1, while upregulated the growth-restricting genes BAX, P21 and P53. ursolic acid 0-12 tumor protein p53 Homo sapiens 168-171 28660943-0 2017 A smart pH-responsive nano-carrier as a drug delivery system for the targeted delivery of ursolic acid: suppresses cancer growth and metastasis by modulating P53/MMP-9/PTEN/CD44 mediated multiple signaling pathways. ursolic acid 90-102 tumor protein p53 Homo sapiens 158-161 29595211-0 2018 Correction: A smart pH-responsive nano-carrier as a drug delivery system for the targeted delivery of ursolic acid: suppresses cancer growth and metastasis by modulating P53/MMP-9/PTEN/CD44 mediated multiple signaling pathways. ursolic acid 102-114 tumor protein p53 Homo sapiens 170-173 29595211-1 2018 Correction for "A smart pH-responsive nano-carrier as a drug delivery system for the targeted delivery of ursolic acid: suppresses cancer growth and metastasis by modulating P53/MMP-9/PTEN/CD44 mediated multiple signaling pathways" by Kai Jiang et al., Nanoscale, 2017, 9, 9428-9439. ursolic acid 106-118 tumor protein p53 Homo sapiens 174-177 28660943-7 2017 Mechanistically, UA@M-CS-FA induced cancer cell apoptosis and inhibited migration via cell cycle arrest in the G0/G1 stage, regulating the PARP/Bcl-2/MMP-9/CD44/PTEN/P53. ursolic acid 17-19 tumor protein p53 Homo sapiens 166-169 28259944-10 2017 Data indicated that ursolic acid nanoparticles, indeed, significantly suppress cervial cancer cell proliferation, invasion and migration compared to the control group, and apoptosis was induced by ursolic acid nanoparticles in cervical cancer cells through activating caspases, p53 and suppressing anti-apoptosis-related signals. ursolic acid 20-32 tumor protein p53 Homo sapiens 278-281 28259944-10 2017 Data indicated that ursolic acid nanoparticles, indeed, significantly suppress cervial cancer cell proliferation, invasion and migration compared to the control group, and apoptosis was induced by ursolic acid nanoparticles in cervical cancer cells through activating caspases, p53 and suppressing anti-apoptosis-related signals. ursolic acid 197-209 tumor protein p53 Homo sapiens 278-281 27496965-0 2016 Ursolic acid, a pentacyclin triterpene, potentiates TRAIL-induced apoptosis through p53-independent up-regulation of death receptors. ursolic acid 0-12 tumor protein p53 Homo sapiens 84-87 27665868-9 2016 UA increases the expression level of p53 in a concentration-dependent manner, and inhibition of p53 reduces the anticancer effect of UA in 143B cells. ursolic acid 0-2 tumor protein p53 Homo sapiens 37-40 27665868-9 2016 UA increases the expression level of p53 in a concentration-dependent manner, and inhibition of p53 reduces the anticancer effect of UA in 143B cells. ursolic acid 133-135 tumor protein p53 Homo sapiens 96-99 27665868-10 2016 Moreover, inhibition of p53 partly reverses the UA-induced downregulation of beta-catenin, as do the targets of Wnt/beta-catenin signaling, such as c-Myc and cyclin D1. ursolic acid 48-50 tumor protein p53 Homo sapiens 24-27 27665868-11 2016 Our findings indicated that UA can inhibit the proliferation of 143B OS cells through inactivation of Wnt/beta-catenin signaling, which may be mediated partly by upregulating the expression of p53. ursolic acid 28-30 tumor protein p53 Homo sapiens 193-196 24375173-7 2014 Mechanistically, the nuclear transportation of p65 and p53 was reduced by UA administration prior to UVR exposure while the levels of p65 and p53 nuclear transportation in SM cells were sustained at a substantially higher level. ursolic acid 74-76 tumor protein p53 Homo sapiens 55-58 24989277-9 2014 Meanwhile, UA up-regulated the mRNA and protein levels of P53 in the same manner. ursolic acid 11-13 tumor protein p53 Homo sapiens 58-61 24375173-9 2014 These results were consistent with reduced proliferation observed in the clonogenic assay, indicating that UA treatment enhanced the phototoxicity of UVR, by modulating the activation of p53 and NF-kappaB and initiating a mitogenic response to optical radiation that triggered mitochondria-dependent apoptosis, particularly in skin melanoma cells. ursolic acid 107-109 tumor protein p53 Homo sapiens 187-190 24071474-0 2013 Ursolic acid induces apoptosis of SW480 cells via p53 activation. ursolic acid 0-12 tumor protein p53 Homo sapiens 50-53 24071474-3 2013 Both the expression level and transcriptional activity of p53, an apoptotic protein, were remarkably up-regulated in cells treated with ursolic acid compared to blank group. ursolic acid 136-148 tumor protein p53 Homo sapiens 58-61 22959527-0 2012 Synthesis of novel ursolic acid heterocyclic derivatives with improved abilities of antiproliferation and induction of p53, p21waf1 and NOXA in pancreatic cancer cells. ursolic acid 19-31 tumor protein p53 Homo sapiens 119-122 12969763-7 2003 In addition, UVA-induced enhanced expression of p53, a hallmark of UV-induced DNA damage and cell death, was also significantly inhibited by pretreatment with asiatic acid or ursolic acid. ursolic acid 175-187 tumor protein p53 Homo sapiens 48-51 24071474-5 2013 Above results demonstrate that ursolic acid induces the activation of p53, NF-kappaB and Bax, leading to the enhancement of p21 transcriptional activity and activation of Caspase-9 and -3, thus finally induces apoptosis of SW480 cells. ursolic acid 31-43 tumor protein p53 Homo sapiens 70-73 21703625-0 2011 Ursolic acid causes DNA-damage, p53-mediated, mitochondria- and caspase-dependent human endothelial cell apoptosis, and accelerates atherosclerotic plaque formation in vivo. ursolic acid 0-12 tumor protein p53 Homo sapiens 32-35 21703625-4 2011 UA causes DNA-damage, followed by the activation of a p53-, BAK-, and caspase-dependent cell-death pathway. ursolic acid 0-2 tumor protein p53 Homo sapiens 54-77 21156789-0 2011 Ursolic acid, a pentacyclin triterpene, potentiates TRAIL-induced apoptosis through p53-independent up-regulation of death receptors: evidence for the role of reactive oxygen species and JNK. ursolic acid 0-12 tumor protein p53 Homo sapiens 84-87 21156789-9 2011 Induction of DRs was independent of p53 because UA induced DR4 and DR5 in HCT116 p53(-/-) cells. ursolic acid 48-50 tumor protein p53 Homo sapiens 81-84 20819578-0 2010 Ursolic acid induces human hepatoma cell line SMMC-7721 apoptosis via p53-dependent pathway. ursolic acid 0-12 tumor protein p53 Homo sapiens 70-73 16104504-12 2005 UA increased p 53 protein expression. ursolic acid 0-2 tumor protein p53 Homo sapiens 13-17 16104504-13 2005 CONCLUSION: The results suggest that UA evokes MCF-7 cell apoptosis is correlation with the up-regulation of p 53. ursolic acid 37-39 tumor protein p53 Homo sapiens 109-113 12792782-6 2003 During UA treatment, we also demonstrated that p53 was phosphorylated at serine 392 and translocated to the nucleus. ursolic acid 7-9 tumor protein p53 Homo sapiens 47-50