PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 27090933-7 2016 Further, combination treatment (UA/RSG) stimulated the IRS-1, PI3-kinase, Akt, and GLUT 4 translocation. ursolic acid 32-34 thymoma viral proto-oncogene 1 Mus musculus 74-77 26567247-12 2017 Our data suggest that UA inhibits miR-21 expression and increases PTEN expression, which in turn inhibits Akt and mTOR and restores normal levels of autophagy. ursolic acid 22-24 thymoma viral proto-oncogene 1 Mus musculus 106-109 26567247-13 2017 Conclusions: Our data suggest that podocyte injury is associated with reduced levels of autophagy during exposure to high glucose conditions, UA attenuated podocyte injury via an increase in autophagy through miR-21 inhibition and PTEN expression, which inhibit the abnormal activation of the PI3K/Akt/mTOR pathway. ursolic acid 142-144 thymoma viral proto-oncogene 1 Mus musculus 298-301 30157245-6 2018 We observe that UA treatment significantly attenuates SCI induced decreases in activated forms of mTOR, and signaling intermediates PI3K, AKT, and S6K, and the upregulation of catabolic genes including FOXO1, MAFbx, MURF-1, and PSMD11. ursolic acid 16-18 thymoma viral proto-oncogene 1 Mus musculus 138-141 27734181-10 2017 Moreover, UA significantly increased the expression of AKT, an Nrf2 upstream factor, suggesting that UA play a neuroprotective role through the activation of the Nrf2-ARE signal pathway. ursolic acid 10-12 thymoma viral proto-oncogene 1 Mus musculus 55-58 27734181-10 2017 Moreover, UA significantly increased the expression of AKT, an Nrf2 upstream factor, suggesting that UA play a neuroprotective role through the activation of the Nrf2-ARE signal pathway. ursolic acid 101-103 thymoma viral proto-oncogene 1 Mus musculus 55-58 27090933-8 2016 These results strongly suggest that combination treatment (UA/RSG) activates IRS-PI3-kinase-Akt-dependent signaling pathways to induce GLUT 4 translocation and increases the expression of insulin receptor to improve glucose intolerance. ursolic acid 59-61 thymoma viral proto-oncogene 1 Mus musculus 92-95 23707761-3 2013 Evidence shows that UA can activate PI3K/Akt signaling and suppress Forkhead box protein O1 (FoxO1) activity. ursolic acid 20-22 thymoma viral proto-oncogene 1 Mus musculus 41-44 26100520-4 2015 The combination of ursolic acid + resveratrol inhibited TPA-induced signaling pathways, including EGFR, STAT3, Src, Akt, Cox-2, Fas, NF-kappaB, p38 MAPK, c-Jun, and JNK1/2 while increasing levels of tumor suppressors, such as p21 and PDCD4, to a greater extent compared with the groups treated with the individual compounds. ursolic acid 19-31 thymoma viral proto-oncogene 1 Mus musculus 116-119 24042330-10 2013 Furthermore, UA suppressed the activation of sonic hedgehog (SHH), STAT3, Akt and p70S6K pathways. ursolic acid 13-15 thymoma viral proto-oncogene 1 Mus musculus 74-77 23707761-8 2013 Moreover, UA attenuated the mitochondrial dysfunction and cognitive deficits through promoting Akt phosphorylation and FoxO1 nuclear exclusion in the hippocampus of DA-treated mice. ursolic acid 10-12 thymoma viral proto-oncogene 1 Mus musculus 95-98 21496491-6 2011 Mechanistically, UA markedly inhibited LPS-induced IkappaBalpha phosphorylation and degradation, NF-kappaB p65 nuclear translocation and p38 activation in mouse brain, but did not affect the activation of TLR4, MyD88, ERK, JNK and Akt. ursolic acid 17-19 thymoma viral proto-oncogene 1 Mus musculus 231-234 22745735-2 2012 We recently found that ursolic acid increases skeletal muscle Akt activity and stimulates muscle growth in non-obese mice. ursolic acid 23-35 thymoma viral proto-oncogene 1 Mus musculus 62-65 22745735-3 2012 Here, we tested the hypothesis that ursolic acid might increase skeletal muscle Akt activity in a mouse model of diet-induced obesity. ursolic acid 36-48 thymoma viral proto-oncogene 1 Mus musculus 80-83 22745735-5 2012 In skeletal muscle, ursolic acid increased Akt activity, as well as downstream mRNAs that promote glucose utilization (hexokinase-II), blood vessel recruitment (Vegfa) and autocrine/paracrine IGF-I signaling (Igf1). ursolic acid 20-32 thymoma viral proto-oncogene 1 Mus musculus 43-46 22427843-6 2012 With respect to the molecular mechanism, we found that UA down-regulated activation of various pro-inflammatory mediators including, NF-kappaB, STAT3, AKT and IKKalpha/beta phosphorylation in the dorsolateral prostate (DLP) tissues that correlated with the reduction in serum levels of TNF-alpha and IL-6. ursolic acid 55-57 thymoma viral proto-oncogene 1 Mus musculus 151-154 33970415-13 2021 Compared with the model group, the expression of PI3K, AKT, and mTOR protein in the ursolic acid group was significantly reduced. ursolic acid 84-96 thymoma viral proto-oncogene 1 Mus musculus 55-58 33970415-15 2021 In conclusion, ursolic acid can inhibit the proliferation and migration of VSMCs in aortic aneurysm mice through the miR-126/PTEN/PI3K/AKT/mTOR signaling pathway. ursolic acid 15-27 thymoma viral proto-oncogene 1 Mus musculus 135-138 30609217-4 2019 Mechanistically, ursolic acid increased AKT and endothelial nitric-oxide synthase (eNOS) phosphorylation levels, and enhanced eNOS expression, while inhibiting doxorubicin induced eNOS uncoupling through NADPH oxidase 4 (NOX4) down-regulation. ursolic acid 17-29 thymoma viral proto-oncogene 1 Mus musculus 40-43 32787765-10 2020 RESULTS: The results obtained in our study have suggested that UA significantly reduced the overexpression of alpha-Synuclein and regulated the phosphorylation of survival-related kinases (Akt and ERK) apart from alleviating the behavioral abnormalities and protecting the dopaminergic neurons from oxidative stress and neuroinflammation. ursolic acid 63-65 thymoma viral proto-oncogene 1 Mus musculus 189-192