PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
16012738-7	2005	A mitochondrial pathway has been suggested to be involved in ursolic acid-induced apoptosis because the treatment induces mitochondria cytochrome c release.	ursolic acid	61-73	cytochrome c, somatic	Homo sapiens	135-147	
29435058-8	2018	In conclusion, these findings demonstrated that ursolic acid activates the apoptosis of prostate cancer via ROCK/PTEN mediated cofilin-1/cytochrome c which mediated caspase-3/9 activities.	ursolic acid	48-60	cytochrome c, somatic	Homo sapiens	137-149	
10925354-4	2000	Furthermore, 30 microM of UA induced DNA fragmentation and subdiploid cells and enhanced the release of cytochrome c and the activation of caspase-3.	ursolic acid	26-28	cytochrome c, somatic	Homo sapiens	104-116	
10925354-5	2000	These results suggest that UA induces cell death through apoptosis, which may be mediated by cytochrome c-dependent caspase-3 activation.	ursolic acid	27-29	cytochrome c, somatic	Homo sapiens	93-105	
10925354-10	2000	Taken together, we suggest that UA-induced cell-cycle arrest may be mediated by inhibition of DNA replication and the increase of p21(WAF1) expression, which induces the release of cytochrome c and the activation of caspase-3, leading to apoptosis of HepG2 cells.	ursolic acid	32-34	cytochrome c, somatic	Homo sapiens	181-193	
25520072-6	2014	These findings imply that induction of apoptosis by ursolic acid stems primarily from the activation of ROCK1 and PTEN, resulting in the translocation of cofilin-1 from cytoplasm to mitochondria, release of cytochrome c, activation of caspase-3 and caspase-9, and finally inducing apoptosis of gastric cancer SGC-7901 cells.	ursolic acid	52-64	cytochrome c, somatic	Homo sapiens	207-219	
27698874-7	2016	Furthermore, cytoplasmic and mitochondrial cytochrome c protein expression was significantly activated and suppressed, respectively, by ursolic acid.	ursolic acid	136-148	cytochrome c, somatic	Homo sapiens	43-55	
24197982-4	2014	In our present study, we found in apoptotic gastric cancer BGC-823 cells induced by ursolic acid that a translocation of cofilin-1 protein from the cytoplasm to the mitochondria promoted the release of cytochrome c from the mitochondria to the cytoplasm, thereby activating the caspase cascade and finally inducing gastric cancer cell apoptosis.	ursolic acid	84-96	cytochrome c, somatic	Homo sapiens	202-214	
23737956-11	2013	Furthermore, UA treatment induced colon cancer cell apoptosis, increased the cleavage of PARP, caspase-3 and 9, and trigged the release of cytochrome c from mitochondrial inter-membrane space into cytosol.	ursolic acid	13-15	cytochrome c, somatic	Homo sapiens	139-151	
24881958-3	2014	Here, we reported that UA induced apoptosis through the mitochondrial intrinsic pathway in HeLa cells, as shown by release of cytosol cytochrome c, activation of caspase-9 and -3, reduction of Bcl-2 and Bcl-xL, and increase of Bax and Bak.	ursolic acid	23-25	cytochrome c, somatic	Homo sapiens	134-146	
24881958-6	2014	U0126 markedly increased UA-induced the Bax/Bcl-2 ratio, the increase of cytosol cytochrome c, and the levels of cleaved caspase-3, but SB203580 had little effects on the above characters, suggesting the ERK1/2 signaling pathway is required for apoptosis.	ursolic acid	25-27	cytochrome c, somatic	Homo sapiens	81-93	
23737956-12	2013	These results indicate that UA inhibits cell proliferation and induces apoptosis in colon cancer cells through simultaneous modulation of the multiple signaling pathways such as MMP9/CDH1, Akt/ERK, COX-2/PGE2, p300/NF-kappaB/CREB2, and cytochrome c/caspase pathways.	ursolic acid	28-30	cytochrome c, somatic	Homo sapiens	236-248	
23330808-6	2013	Moreover, we found that the enhanced effects of UA and melatonin combination are mediated through simultaneous modulation of cytochrome c/caspase, MMP9/COX-2, and p300/NF-kappaB signaling pathways.	ursolic acid	48-50	cytochrome c, somatic	Homo sapiens	125-137	
23330808-7	2013	Combined treatment with UA and melatonin triggered the release of cytochrome c from the mitochondrial intermembrane space into the cytosol, induced cleavage of caspase and PARP proteins, enhanced inhibition of MMP9 and COX-2 expression, promoted p300 and NF-kappaB translocation from cell nuclei to cytoplasm, and abrogated NF-kappaB binding and p300 recruitment to COX-2 promoter in colon cancer cells.	ursolic acid	24-26	cytochrome c, somatic	Homo sapiens	66-78	
21910059-6	2011	We also found that ursolic acid induced Bax up-regulation and Bcl-2 down-regulation and release of cytochrome C to the cytosol from mitochondria.	ursolic acid	19-31	cytochrome c, somatic	Homo sapiens	99-111	
19908232-7	2010	Chemosensitization by ursolic acid in cancer cells was dependent on the amplified activation of intrinsic pathway (caspase-8-BID-mitochondria-cytochrome c-caspase-3) by augmentation of BID cleavage and activation of Fas/FasL-caspase-8 pathway.	ursolic acid	22-34	cytochrome c, somatic	Homo sapiens	142-154	
20415421-6	2010	OA and UA-induced apoptosis involving the release of mitochondria cytochrome c into the cytosol and subsequently induced the activation of caspase-9 and caspase-3, followed by cleavage of poly (ADP-ribose) polymerase (PARP).	ursolic acid	7-9	cytochrome c, somatic	Homo sapiens	66-78	
20137120-5	2010	Caspase-9, caspase-3 and cytochrome C were activated, and the phosphorylation of Akt was inhibited in the Jurkat cell apoptosis process induced by UA.	ursolic acid	147-149	cytochrome c, somatic	Homo sapiens	25-37	
22477202-4	2012	Here, we demonstrated that UA was able to inhibit growth, induce apoptosis in a human chronic myelogenous leukemia cell line (K562 cells) via upregulation of PTEN gene expression, inhibit Akt kinase activity, change mitochondrial transmembrane potential and reduce the release of cytochrome c and the activity of caspases.	ursolic acid	27-29	cytochrome c, somatic	Homo sapiens	280-292