PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
24399733-0	2013	Inhibition of Wnt/beta-catenin signaling mediates ursolic acid-induced apoptosis in PC-3 prostate cancer cells.	ursolic acid	50-62	actin related protein 1B	Homo sapiens	84-88	
24399733-3	2013	To investigate the antitumor mechanism, the apoptotic mechanism of ursolic acid via Wnt/beta-catenin signaling was examined in PC-3 prostate cancer cells.	ursolic acid	67-79	actin related protein 1B	Homo sapiens	127-131	
24399733-5	2013	RESULTS: Ursolic acid showed cytotoxicity against PC-3, LNCaP and DU145 prostate cancer cells with IC50 of 35 muM, 47 muM and 80 muM, respectively.	ursolic acid	9-21	actin related protein 1B	Homo sapiens	50-54	
24399733-6	2013	Also, ursolic acid significantly increased the number of ethidium homodimer stained cells and apoptotic bodies, and dose-dependently enhanced the sub-G1 apoptotic accumulation in PC-3 cells.	ursolic acid	6-18	actin related protein 1B	Homo sapiens	179-183	
24399733-7	2013	Consistently, western blotting revealed that ursolic acid effectively cleaved poly (ADP-ribose) polymerase (PARP), activated caspase-9 and -3, suppressed the expression of survival proteins such as Bcl-XL, Bcl-2 and Mcl-1, and upregulated the expression of Bax in PC-3 cells.	ursolic acid	45-57	actin related protein 1B	Homo sapiens	264-268	
24399733-9	2013	Furthermore, the GSK3beta inhibitor SB216763 or Wnt3a-conditioned medium (Wnt3a-CM) reversed the cleavages of caspase-3 and PARP induced by ursolic acid in PC-3 cells.	ursolic acid	140-152	actin related protein 1B	Homo sapiens	156-160	
24399733-10	2013	CONCLUSIONS: Our findings suggest that ursolic acid induces apoptosis via inhibition of the Wnt5/beta-catenin pathway and activation of caspase in PC-3 prostate cancer cells.	ursolic acid	39-51	actin related protein 1B	Homo sapiens	147-151