PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
30703491-2	2019	AIM OF THE STUDY: Pentacyclic triterpenoids (PTs), especially ursolic acid (UA), have been found as reversibly and competitively human neutrophil elastase (HNE) inhibitors.	ursolic acid	62-74	elastase, neutrophil expressed	Homo sapiens	135-154	
1859379-0	1991	Inhibition of human leucocyte elastase by ursolic acid.	ursolic acid	42-54	elastase, neutrophil expressed	Homo sapiens	30-38	
1859379-4	1991	With tripeptide and tetrapeptide substrates, the inhibition is purely competitive, whereas with a shorter dipeptide substrate the inhibition is non-competitive, suggesting that ursolic acid interacts with subsite S3 of the extended substrate-binding domain in HLE, but not with subsites S1 and S2.	ursolic acid	177-189	elastase, neutrophil expressed	Homo sapiens	260-263	
1859379-5	1991	The carboxy group at position 28 in the pentacyclic-ring system of the triterpenes contributes to binding to HLE, since replacement of this group with a hydroxy group, as in uvaol, the alcohol analogue of ursolic acid, reduces the potency of inhibition.	ursolic acid	205-217	elastase, neutrophil expressed	Homo sapiens	109-112	
1859379-6	1991	The inhibitory potency of ursolic acid is also reduced by addition of 1 M-NaCl, further supporting a postulated electrostatic interaction between the negative charge on the triterpene and a positively charged residue on the enzyme, which we assign to the side chain of Arg-217, located in the vicinity of subsites S4 and S5 in HLE.	ursolic acid	26-38	elastase, neutrophil expressed	Homo sapiens	327-330	
9103531-4	1997	The data show that the dual inhibition of 5-lipoxygenase and HLE is unique to boswellic acids: other pentacyclic triterpenes with HLE inhibitory activities (e.g., ursolic acid and amyrin) do not inhibit 5-lipoxygenase, and leukotriene biosynthesis inhibitors from different chemical classes (e.g., NDGA, MK-886 and ZM-230,487) do not impair HLE activity.	ursolic acid	163-175	elastase, neutrophil expressed	Homo sapiens	61-64	
30703491-2	2019	AIM OF THE STUDY: Pentacyclic triterpenoids (PTs), especially ursolic acid (UA), have been found as reversibly and competitively human neutrophil elastase (HNE) inhibitors.	ursolic acid	76-78	elastase, neutrophil expressed	Homo sapiens	135-154	
24376583-7	2013	The HNE inhibitory activity of ursolic acid was further verified using a mouse model of acute smoke-induced lung inflammation.	ursolic acid	31-43	elastase, neutrophil expressed	Homo sapiens	4-7	
26777089-4	2016	Two natural well known HNE inhibitors from the triterpene family, ursolic acid and oleanolic acid, were tested to validate the developed assay.	ursolic acid	66-78	elastase, neutrophil expressed	Homo sapiens	23-26	
26777089-14	2016	Furthermore, MST technique was used for evaluating HNE interaction with the ursolic acid.	ursolic acid	76-88	elastase, neutrophil expressed	Homo sapiens	51-54	
26777089-15	2016	Up to 16 capillaries were automatically processed to obtain in one titration experiment the dissociation constant for the HNE-ursolic acid complex.	ursolic acid	126-138	elastase, neutrophil expressed	Homo sapiens	122-125