PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
24334003-0	2014	Accentuation of ursolic acid on muscarinic receptor-induced ANP secretion in beating rabbit atria.	ursolic acid	16-28	natriuretic peptides A	Oryctolagus cuniculus	60-63	
24334003-1	2014	AIMS: Ursolic acid has recently been reported to increase both atrial natriuretic peptide (ANP) secretion and mechanical dynamics in rabbit atria.	ursolic acid	6-18	natriuretic peptides A	Oryctolagus cuniculus	63-89	
24334003-1	2014	AIMS: Ursolic acid has recently been reported to increase both atrial natriuretic peptide (ANP) secretion and mechanical dynamics in rabbit atria.	ursolic acid	6-18	natriuretic peptides A	Oryctolagus cuniculus	91-94	
24334003-2	2014	MAIN METHODS: The present study was designed to clarify the regulatory effects of ursolic acid on the beta-adrenergic or muscarinic receptor-mediated changes in ANP secretory and contractile function allowing measurement of atrial dynamics such as pulse pressure, stroke volume, and cAMP efflux in isolated perfused beating rabbit atria.	ursolic acid	82-94	natriuretic peptides A	Oryctolagus cuniculus	161-164	
24334003-3	2014	KEY FINDINGS: Pretreatment with ursolic acid significantly attenuated the isoproterenol (beta-adrenergic agonist)-induced decrease in ANP secretion and increases in cAMP levels and atrial dynamics.	ursolic acid	32-44	natriuretic peptides A	Oryctolagus cuniculus	134-137	
24334003-4	2014	Interestingly, ursolic acid concentration-dependently accentuated the acetylcholine-induced increase in ANP secretion and decrease in pulse pressure in the presence of isoproterenol (p<0.001).	ursolic acid	15-27	natriuretic peptides A	Oryctolagus cuniculus	104-107	
24334003-5	2014	These findings indicate that acetylcholine-induced increase in ANP secretion is potentiated by ursolic acid; furthermore, acetylcholine-induced decrease in atrial dynamics is also potentiated by ursolic acid, suggesting that ursolic acid regulates muscarinic receptor-mediated secretory and contractile responses in perfused beating rabbit atria.	ursolic acid	95-107	natriuretic peptides A	Oryctolagus cuniculus	63-66	
21122803-0	2011	Ursolic acid increases the secretion of atrial natriuretic peptide in isolated perfused beating rabbit atria.	ursolic acid	0-12	natriuretic peptides A	Oryctolagus cuniculus	40-66	
21122803-6	2011	Ursolic acid increased ANP secretion and mechanical dynamics in a concentration-dependent manner.	ursolic acid	0-12	natriuretic peptides A	Oryctolagus cuniculus	23-26	
21122803-7	2011	The inhibition of L-type Ca(2+) channels with nifedipine attenuated the ursolic acid-induced increase in ANP secretion but not mechanical dynamics.	ursolic acid	72-84	natriuretic peptides A	Oryctolagus cuniculus	105-108	
21122803-8	2011	The inhibition of K(+)(ATP) channels with glibenclamide attenuated the ursolic acid-induced increase in ANP secretion-but not atrial dynamics-in a concentration-dependent manner.	ursolic acid	71-83	natriuretic peptides A	Oryctolagus cuniculus	104-107	
21122803-10	2011	These findings show that ursolic acid increases ANP secretion via its activation of K(+)(ATP) channels and subsequent inhibition of Ca(2+) entry through L-type Ca(2+) channels in rabbit atria.	ursolic acid	25-37	natriuretic peptides A	Oryctolagus cuniculus	48-51