PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 17404266-6 2007 The release of UA-induced IL-1beta was significantly inhibited by the inhibitors of p38 MAPK, MEK1/2, ATP-binding cassette transporter, and caspase-1. ursolic acid 15-17 mitogen-activated protein kinase kinase 1 Mus musculus 94-100 29128805-0 2017 Ursolic acid affords antidepressant-like effects in mice through the activation of PKA, PKC, CAMK-II and MEK1/2. ursolic acid 0-12 mitogen-activated protein kinase kinase 1 Mus musculus 105-111 29128805-6 2017 CONCLUSIONS: These results suggest that activation of PKA, PKC, CAMK-II, MEK1/2 may underlie the antidepressant-like effects of ursolic acid. ursolic acid 128-140 mitogen-activated protein kinase kinase 1 Mus musculus 73-79 16188240-5 2005 In addition, UA-promoted MIF release was significantly inhibited by PD98059, a MEK1/2 inhibitor, while siRNA for ERK2, but not ERK1, significantly decreased the amount of MIF protein released. ursolic acid 13-15 mitogen-activated protein kinase kinase 1 Mus musculus 79-85