PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
26362062-0	2015	Activation of SAPK/JNK mediated the inhibition and reciprocal interaction of DNA methyltransferase 1 and EZH2 by ursolic acid in human lung cancer cells.	ursolic acid	113-125	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	105-109	
26362062-8	2015	Furthermore, we found that UA induced phosphorylation of SAPK/JNK and suppressed the protein expression of DNMT1 and EZH2.	ursolic acid	27-29	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	117-121	
26362062-11	2015	Conversely, overexpression of SP1 reversed the effect of UA on DNMT1 and EZH2 expression, and feedback attenuated UA-induced phosphorylation of SAPK/JNK.	ursolic acid	57-59	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	73-77	
26362062-13	2015	CONCLUSION: Our results show that UA inhibits growth of NSCLC cells through SAPK/JNK-mediated inhibition of SP1; this in turn results in inhibition the expression of DNMT1 and EZH2.	ursolic acid	34-36	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	176-180	
26362062-15	2015	The negative feedback regulation of SAPK/JNK signaling by SP1 and DNMT1, and the reciprocal interaction of EZH2 and DNMT1 contribute to the overall effects of UA.	ursolic acid	159-161	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	107-111