PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
28950243-0	2017	Design, synthesis, and evaluation of novel ursolic acid derivatives as HIF-1alpha inhibitors with anticancer potential.	ursolic acid	43-55	hypoxia inducible factor 1 subunit alpha	Homo sapiens	71-81	
31006525-3	2019	Here, we designed and synthesized 31 ursolic acid (UA) derivatives containing a tetrazole moiety and evaluated them for their potential anti-tumor activities as HIF-1alpha transcriptional inhibitors.	ursolic acid	37-49	hypoxia inducible factor 1 subunit alpha	Homo sapiens	161-171	
31006525-3	2019	Here, we designed and synthesized 31 ursolic acid (UA) derivatives containing a tetrazole moiety and evaluated them for their potential anti-tumor activities as HIF-1alpha transcriptional inhibitors.	ursolic acid	51-53	hypoxia inducible factor 1 subunit alpha	Homo sapiens	161-171	
30728113-0	2019	Design, synthesis, and screening of novel ursolic acid derivatives as potential anti-cancer agents that target the HIF-1alpha pathway.	ursolic acid	42-54	hypoxia inducible factor 1 subunit alpha	Homo sapiens	115-125	
30728113-2	2019	Here, we designed and synthesized three novel series of ursolic acid derivatives containing an aminoguanidine moiety and evaluated them as HIF-1alpha inhibitors and anti-cancer agents using human cancer cell lines.	ursolic acid	56-68	hypoxia inducible factor 1 subunit alpha	Homo sapiens	139-149	
28950243-2	2017	In this work, four novel series of ursolic acid derivatives containing oxadiazole, triazolone, and piperazine moieties were designed, synthesized, and evaluated for anti-tumor activity as HIF-1alpha inhibitors.	ursolic acid	35-47	hypoxia inducible factor 1 subunit alpha	Homo sapiens	188-198	
28356955-0	2017	Ursolic acid sensitizes radioresistant NSCLC cells expressing HIF-1alpha through reducing endogenous GSH and inhibiting HIF-1alpha.	ursolic acid	0-12	hypoxia inducible factor 1 subunit alpha	Homo sapiens	62-72	
28356955-0	2017	Ursolic acid sensitizes radioresistant NSCLC cells expressing HIF-1alpha through reducing endogenous GSH and inhibiting HIF-1alpha.	ursolic acid	0-12	hypoxia inducible factor 1 subunit alpha	Homo sapiens	120-130	
28356955-6	2017	The irradiated H1299/M-HIF-1alpha cells were more sensitive to UA pretreatment than the irradiated cells with empty plasmid and control.	ursolic acid	63-65	hypoxia inducible factor 1 subunit alpha	Homo sapiens	23-33	
28356955-10	2017	The results revealed that UA treatment alone could effectively decrease the GSH content in H1299/M-HIF-1alpha cells.	ursolic acid	26-28	hypoxia inducible factor 1 subunit alpha	Homo sapiens	99-109	
28356955-12	2017	It was then concluded that UA could upregulate the radiosensitivity of NSCLC cells, and in particular reduce the refractory response of cells expressing HIF-1alpha to ionizing radiation.	ursolic acid	27-29	hypoxia inducible factor 1 subunit alpha	Homo sapiens	153-163	
27221674-0	2016	Ursolic acid inhibits proliferation and reverses drug resistance of ovarian cancer stem cells by downregulating ABCG2 through suppressing the expression of hypoxia-inducible factor-1alpha in vitro.	ursolic acid	0-12	hypoxia inducible factor 1 subunit alpha	Homo sapiens	156-187	
27221674-5	2016	The expression of HIF-1alpha and ABCG2 was tested using quantitative PCR, western blotting, and immuno-fluorescence under different culture conditions and treated with UA.	ursolic acid	168-170	hypoxia inducible factor 1 subunit alpha	Homo sapiens	18-28	
27221674-9	2016	UA could inhibit proliferation and reverse the drug resistance of ovarian CSC by suppressing ABCG2 and HIF-1alpha under different culture conditions.	ursolic acid	0-2	hypoxia inducible factor 1 subunit alpha	Homo sapiens	103-113	
27221674-11	2016	The PI3K/Akt signaling pathway activation plays an important functional role in UA-induced downregulation of HIF-1alpha and reduction of ABCG2.	ursolic acid	80-82	hypoxia inducible factor 1 subunit alpha	Homo sapiens	109-119	
27221674-12	2016	UA inhibits the proliferation and reversal of drug resistance in ovarian CSCs by suppressing the expression of downregulation of HIF-1alpha and ABCG2.	ursolic acid	0-2	hypoxia inducible factor 1 subunit alpha	Homo sapiens	129-139	
27604859-0	2016	Ursolic acid sensitized colon cancer cells to chemotherapy under hypoxia by inhibiting MDR1 through HIF-1alpha.	ursolic acid	0-12	hypoxia inducible factor 1 subunit alpha	Homo sapiens	100-110	
27604859-10	2016	Moreover, ursolic acid was capable of inhibiting HIF-1alpha accumulation with little effects on its constitutional expression in normoxia.	ursolic acid	10-22	hypoxia inducible factor 1 subunit alpha	Homo sapiens	49-59	
27604859-12	2016	CONCLUSIONS: Ursolic acid exerted chemosensitizing effects in colon cancer cells under hypoxia by inhibiting HIF-1alpha accumulation and the subsequent expression of the MDR1 and VEGF.	ursolic acid	13-25	hypoxia inducible factor 1 subunit alpha	Homo sapiens	109-119