PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 31527378-3 2020 Here, we identified ursolic acid (UA) as a natural inhibitor of COX-2 and investigated its effects on endometriosis progression. ursolic acid 20-32 prostaglandin-endoperoxide synthase 2 Homo sapiens 64-69 31527378-3 2020 Here, we identified ursolic acid (UA) as a natural inhibitor of COX-2 and investigated its effects on endometriosis progression. ursolic acid 34-36 prostaglandin-endoperoxide synthase 2 Homo sapiens 64-69 31527378-12 2020 CONCLUSIONS: Our data suggest that UA plays a role as a natural inhibitor of COX-2 to control the survival of human endometriotic stromal cells by inhibiting proliferation and angiogenesis and promoting apoptosis. ursolic acid 35-37 prostaglandin-endoperoxide synthase 2 Homo sapiens 77-82 27262506-0 2016 Resistance to ursolic acid-induced apoptosis through involvement of melanogenesis and COX-2/PGE2 pathways in human M4Beu melanoma cancer cells. ursolic acid 14-26 prostaglandin-endoperoxide synthase 2 Homo sapiens 86-91 29190954-0 2017 Cyclooxygenase-2 mediated synergistic effect of ursolic acid in combination with paclitaxel against human gastric carcinoma. ursolic acid 48-60 prostaglandin-endoperoxide synthase 2 Homo sapiens 0-16 29190954-1 2017 Ursolic acid (UA) induces apoptosis in gastric cancer cells by inhibiting cyclooxygenase-2 (COX-2). ursolic acid 0-12 prostaglandin-endoperoxide synthase 2 Homo sapiens 74-90 29190954-1 2017 Ursolic acid (UA) induces apoptosis in gastric cancer cells by inhibiting cyclooxygenase-2 (COX-2). ursolic acid 0-12 prostaglandin-endoperoxide synthase 2 Homo sapiens 92-97 29190954-1 2017 Ursolic acid (UA) induces apoptosis in gastric cancer cells by inhibiting cyclooxygenase-2 (COX-2). ursolic acid 14-16 prostaglandin-endoperoxide synthase 2 Homo sapiens 74-90 29190954-1 2017 Ursolic acid (UA) induces apoptosis in gastric cancer cells by inhibiting cyclooxygenase-2 (COX-2). ursolic acid 14-16 prostaglandin-endoperoxide synthase 2 Homo sapiens 92-97 29190954-7 2017 Combined delivery of UA and PTX synergistically reduced cell proliferation and induced apoptosis in these cells by lowering COX-2, PCNA, and Bcl-2 expression and by increasing Bax expression. ursolic acid 21-23 prostaglandin-endoperoxide synthase 2 Homo sapiens 124-129 29190954-8 2017 These results indicate that the synergistic inhibition of proliferation and induction of apoptosis by UA and PTX may be induced by reducing COX-2 expression in gastric cancer cells. ursolic acid 102-104 prostaglandin-endoperoxide synthase 2 Homo sapiens 140-145 24638056-0 2014 Inhibition of HepG2 cell proliferation by ursolic acid and polysaccharides via the downregulation of cyclooxygenase-2. ursolic acid 42-54 prostaglandin-endoperoxide synthase 2 Homo sapiens 101-117 21251952-0 2011 HT-29 colorectal cancer cells undergoing apoptosis overexpress COX-2 to delay ursolic acid-induced cell death. ursolic acid 78-90 prostaglandin-endoperoxide synthase 2 Homo sapiens 63-68 23194884-0 2013 Delivery of ursolic acid (UA) in polymeric nanoparticles effectively promotes the apoptosis of gastric cancer cells through enhanced inhibition of cyclooxygenase 2 (COX-2). ursolic acid 12-24 prostaglandin-endoperoxide synthase 2 Homo sapiens 147-163 23194884-0 2013 Delivery of ursolic acid (UA) in polymeric nanoparticles effectively promotes the apoptosis of gastric cancer cells through enhanced inhibition of cyclooxygenase 2 (COX-2). ursolic acid 12-24 prostaglandin-endoperoxide synthase 2 Homo sapiens 165-170 23194884-0 2013 Delivery of ursolic acid (UA) in polymeric nanoparticles effectively promotes the apoptosis of gastric cancer cells through enhanced inhibition of cyclooxygenase 2 (COX-2). ursolic acid 26-28 prostaglandin-endoperoxide synthase 2 Homo sapiens 147-163 23194884-0 2013 Delivery of ursolic acid (UA) in polymeric nanoparticles effectively promotes the apoptosis of gastric cancer cells through enhanced inhibition of cyclooxygenase 2 (COX-2). ursolic acid 26-28 prostaglandin-endoperoxide synthase 2 Homo sapiens 165-170 23194884-1 2013 It has been demonstrated that ursolic acid (UA) could effectively induces apoptosis of cancer cells by inhibiting the expression of cyclooxygenase 2 (COX-2), which constitutively expresses in gastric cancer. ursolic acid 30-42 prostaglandin-endoperoxide synthase 2 Homo sapiens 132-148 23194884-1 2013 It has been demonstrated that ursolic acid (UA) could effectively induces apoptosis of cancer cells by inhibiting the expression of cyclooxygenase 2 (COX-2), which constitutively expresses in gastric cancer. ursolic acid 30-42 prostaglandin-endoperoxide synthase 2 Homo sapiens 150-155 23194884-1 2013 It has been demonstrated that ursolic acid (UA) could effectively induces apoptosis of cancer cells by inhibiting the expression of cyclooxygenase 2 (COX-2), which constitutively expresses in gastric cancer. ursolic acid 44-46 prostaglandin-endoperoxide synthase 2 Homo sapiens 132-148 23194884-1 2013 It has been demonstrated that ursolic acid (UA) could effectively induces apoptosis of cancer cells by inhibiting the expression of cyclooxygenase 2 (COX-2), which constitutively expresses in gastric cancer. ursolic acid 44-46 prostaglandin-endoperoxide synthase 2 Homo sapiens 150-155 23194884-7 2013 The most powerful evidence from this report is that the significant differences between the cytotoxicity of free UA and UA-NPs are closely related to the expression levels of COX-2 and caspase-3, which demonstrates the superiority of UA-NPs over free UA through penetrating cell membrane. ursolic acid 113-115 prostaglandin-endoperoxide synthase 2 Homo sapiens 175-180 23194884-7 2013 The most powerful evidence from this report is that the significant differences between the cytotoxicity of free UA and UA-NPs are closely related to the expression levels of COX-2 and caspase-3, which demonstrates the superiority of UA-NPs over free UA through penetrating cell membrane. ursolic acid 120-122 prostaglandin-endoperoxide synthase 2 Homo sapiens 175-180 23194884-7 2013 The most powerful evidence from this report is that the significant differences between the cytotoxicity of free UA and UA-NPs are closely related to the expression levels of COX-2 and caspase-3, which demonstrates the superiority of UA-NPs over free UA through penetrating cell membrane. ursolic acid 120-122 prostaglandin-endoperoxide synthase 2 Homo sapiens 175-180 23194884-7 2013 The most powerful evidence from this report is that the significant differences between the cytotoxicity of free UA and UA-NPs are closely related to the expression levels of COX-2 and caspase-3, which demonstrates the superiority of UA-NPs over free UA through penetrating cell membrane. ursolic acid 120-122 prostaglandin-endoperoxide synthase 2 Homo sapiens 175-180 22521508-0 2012 The P2Y2/Src/p38/COX-2 pathway is involved in the resistance to ursolic acid-induced apoptosis in colorectal and prostate cancer cells. ursolic acid 64-76 prostaglandin-endoperoxide synthase 2 Homo sapiens 17-22 22521508-3 2012 Previously, we showed that HT-29 colorectal cancer cells undergoing apoptosis overexpressed cyclooxygenase-2 (COX-2), in a p38 dependent pathway, to delay ursolic acid-induced apoptosis. ursolic acid 155-167 prostaglandin-endoperoxide synthase 2 Homo sapiens 92-108 22521508-3 2012 Previously, we showed that HT-29 colorectal cancer cells undergoing apoptosis overexpressed cyclooxygenase-2 (COX-2), in a p38 dependent pathway, to delay ursolic acid-induced apoptosis. ursolic acid 155-167 prostaglandin-endoperoxide synthase 2 Homo sapiens 110-115 21251952-4 2011 In this study, we focused our interest on the role played by COX-2 in apoptosis induced in HT-29 human colorectal cancer cells by ursolic acid (UA), a triterpenoid found in a large variety of plants. ursolic acid 130-142 prostaglandin-endoperoxide synthase 2 Homo sapiens 61-66 21251952-4 2011 In this study, we focused our interest on the role played by COX-2 in apoptosis induced in HT-29 human colorectal cancer cells by ursolic acid (UA), a triterpenoid found in a large variety of plants. ursolic acid 144-146 prostaglandin-endoperoxide synthase 2 Homo sapiens 61-66 21251952-8 2011 These results demonstrated that COX-2 was involved in a resistance mechanism to UA-induced apoptosis in HT-29 cells. ursolic acid 80-82 prostaglandin-endoperoxide synthase 2 Homo sapiens 32-37 16613675-3 2006 This study was to investigate the effect of UA on COX-2, Bcl-2 and Bax expression in human gastric cancer cell line SGC7901, and explore its potential mechanisms of inhibiting proliferation and inducing apoptosis. ursolic acid 44-46 prostaglandin-endoperoxide synthase 2 Homo sapiens 50-55 16613675-9 2006 When treated with 20-40 micromol/L UA for 24 h, SGC7901 cells were arrested at G0/G1 phase, and the apoptosis rates were (9.10+/-2.39)%, (26.30+/-1.25)%, and (35.20+/-2.26)%, respectively; meanwhile, COX-2 expression and its catalysate PGE2 were decreased, Bcl-2 expression was also decreased, whereas Bax expression was unchanged. ursolic acid 35-37 prostaglandin-endoperoxide synthase 2 Homo sapiens 200-205 16613675-10 2006 CONCLUSION: UA could inhibit proliferation and induce apoptosis of SGC7901 cells through arresting cell cycle, inhibiting COX-2 expression to reduce PGE2 production and down-regulate Bcl-2 expression. ursolic acid 12-14 prostaglandin-endoperoxide synthase 2 Homo sapiens 122-127 12907607-0 2003 Ursolic acid inhibits nuclear factor-kappaB activation induced by carcinogenic agents through suppression of IkappaBalpha kinase and p65 phosphorylation: correlation with down-regulation of cyclooxygenase 2, matrix metalloproteinase 9, and cyclin D1. ursolic acid 0-12 prostaglandin-endoperoxide synthase 2 Homo sapiens 190-206 16521214-7 2006 Downregulation of cyclooxygenase-2 (COX-2) protein and upregulation of heat shock protein (HSP) 105 mRNA correlated to the apoptosis of HepG2 cells treated with UA. ursolic acid 161-163 prostaglandin-endoperoxide synthase 2 Homo sapiens 36-41 16521214-7 2006 Downregulation of cyclooxygenase-2 (COX-2) protein and upregulation of heat shock protein (HSP) 105 mRNA correlated to the apoptosis of HepG2 cells treated with UA. ursolic acid 161-163 prostaglandin-endoperoxide synthase 2 Homo sapiens 18-34 10811116-0 2000 Ursolic acid inhibits cyclooxygenase-2 transcription in human mammary epithelial cells. ursolic acid 0-12 prostaglandin-endoperoxide synthase 2 Homo sapiens 22-38 10811116-1 2000 We investigated the effects of ursolic acid, a chemopreventive agent, on the expression of cyclooxygenase-2 (COX-2) in phorbol 12-myristate 13-acetate (PMA)-treated human mammary and oral epithelial cells. ursolic acid 31-43 prostaglandin-endoperoxide synthase 2 Homo sapiens 91-107 10811116-7 2000 Treatment with PMA increased activator protein-1 activity and the binding of c-Jun to the cyclic AMP response element of the COX-2 promoter, effects that were blocked by ursolic acid. ursolic acid 170-182 prostaglandin-endoperoxide synthase 2 Homo sapiens 125-130 10811116-1 2000 We investigated the effects of ursolic acid, a chemopreventive agent, on the expression of cyclooxygenase-2 (COX-2) in phorbol 12-myristate 13-acetate (PMA)-treated human mammary and oral epithelial cells. ursolic acid 31-43 prostaglandin-endoperoxide synthase 2 Homo sapiens 109-114 10811116-2 2000 Treatment with ursolic acid suppressed PMA-mediated induction of COX-2 protein and synthesis of prostaglandin E2. ursolic acid 15-27 prostaglandin-endoperoxide synthase 2 Homo sapiens 65-70 10811116-3 2000 Ursolic acid also suppressed the induction of COX-2 mRNA by PMA. ursolic acid 0-12 prostaglandin-endoperoxide synthase 2 Homo sapiens 46-51 10811116-4 2000 Nuclear run-offs revealed increased rates of COX-2 transcription after treatment with PMA, an effect that was inhibited by ursolic acid. ursolic acid 123-135 prostaglandin-endoperoxide synthase 2 Homo sapiens 45-50