PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 28338932-0 2017 Ursolic acid derivative FZU-03,010 inhibits STAT3 and induces cell cycle arrest and apoptosis in renal and breast cancer cells. ursolic acid 0-12 signal transducer and activator of transcription 3 Homo sapiens 44-49 30597956-0 2018 Ursolic Acid Induces Apoptosis in Colorectal Cancer Cells Partially via Upregulation of MicroRNA-4500 and Inhibition of JAK2/STAT3 Phosphorylation. ursolic acid 0-12 signal transducer and activator of transcription 3 Homo sapiens 125-130 30597956-2 2018 Thus, in the present study, the apoptotic mechanism of ursolic acid was elucidated in HCT116 and HT29 colorectal cancer cells in association with STAT3 and microRNA-4500 (miR-4500) by MTT assay, Terminal deoxynucleotidyl transferase-dT-mediated dUTP nick end labelling (TUNEL) assay, cell cycle analysis, immunofluorescence, and Western blotting. ursolic acid 55-67 signal transducer and activator of transcription 3 Homo sapiens 146-151 30597956-4 2018 Of note, ursolic acid attenuated the expression of anti-apoptotic proteins such as Janus kinase 2 (JAK2) and signal transducer and activator of transcription 3 (STAT3) and also blocked nuclear translocation of STAT3 in colorectal cancer cells. ursolic acid 9-21 signal transducer and activator of transcription 3 Homo sapiens 109-159 30597956-4 2018 Of note, ursolic acid attenuated the expression of anti-apoptotic proteins such as Janus kinase 2 (JAK2) and signal transducer and activator of transcription 3 (STAT3) and also blocked nuclear translocation of STAT3 in colorectal cancer cells. ursolic acid 9-21 signal transducer and activator of transcription 3 Homo sapiens 161-166 30597956-4 2018 Of note, ursolic acid attenuated the expression of anti-apoptotic proteins such as Janus kinase 2 (JAK2) and signal transducer and activator of transcription 3 (STAT3) and also blocked nuclear translocation of STAT3 in colorectal cancer cells. ursolic acid 9-21 signal transducer and activator of transcription 3 Homo sapiens 210-215 30597956-5 2018 Notably, ursolic acid increased the expression level of miR-4500 in HCT116 cells by qRT-PCR analysis and conversely miR-4500 inhibitor reversed cytotoxic, anti-proliferative, and apoptotic effects by increasing TUNEL positive cells, PARP cleavage and inhibiting p-STAT3 in ursolic acid treated colorectal cancer cells. ursolic acid 9-21 signal transducer and activator of transcription 3 Homo sapiens 264-269 30181206-0 2018 Editor"s Note: Ursolic Acid Inhibits STAT3 Activation Pathway Leading to Suppression of Proliferation and Chemosensitization of Human Multiple Myeloma Cells. ursolic acid 15-27 signal transducer and activator of transcription 3 Homo sapiens 37-42 28714512-0 2017 Inhibition of STAT3 signaling pathway by ursolic acid suppresses growth of hepatocellular carcinoma. ursolic acid 41-53 signal transducer and activator of transcription 3 Homo sapiens 14-19 28714512-4 2017 However, whether UA could inhibit STAT3 phosphorylation in hepatocellular carcinoma has not been reported. ursolic acid 17-19 signal transducer and activator of transcription 3 Homo sapiens 34-39 28714512-5 2017 The inhibitory effects of UA on STAT3 phosphorylation, along with cell viability, migration, colony formation in vitro, as well as tumor growth in vivo were examined in human liver cancer cell lines. ursolic acid 26-28 signal transducer and activator of transcription 3 Homo sapiens 32-37 28714512-6 2017 Our data showed that UA inhibited the P-STAT3 induced by interleukin-6 (IL-6) in Hep3B liver cancer cells which express very low basal level of P-STAT3. ursolic acid 21-23 signal transducer and activator of transcription 3 Homo sapiens 40-45 28714512-6 2017 Our data showed that UA inhibited the P-STAT3 induced by interleukin-6 (IL-6) in Hep3B liver cancer cells which express very low basal level of P-STAT3. ursolic acid 21-23 signal transducer and activator of transcription 3 Homo sapiens 146-151 28714512-7 2017 The constitutive STAT3 phosphorylation was also inhibited by UA in HEPG2, 7721 and Huh7 human liver cancer cell lines. ursolic acid 61-63 signal transducer and activator of transcription 3 Homo sapiens 17-22 28714512-8 2017 UA decreased the expression of downstream target genes of STAT3, such as Bcl-2, Bcl-xl and survivin in general, with difference in these cell lines. ursolic acid 0-2 signal transducer and activator of transcription 3 Homo sapiens 58-63 28714512-11 2017 UA, which exists widely in fruits and herbs, could inhibit STAT3 activation and the growth of human liver cancer cells in vitro and in vivo. ursolic acid 0-2 signal transducer and activator of transcription 3 Homo sapiens 59-64 22549898-7 2013 In the Hep3B system, UA dramatically suppressed AMF/PGI-induced anti-apoptotic signaling transmission, including Akt, p85, Bad, and Stat3 phosphorylation. ursolic acid 21-23 signal transducer and activator of transcription 3 Homo sapiens 132-137 26909608-9 2016 UA inhibited the activation of NF-kappaB and STAT3 and the expression of tumorigenic proteins regulated by these inflammatory transcription factors in tumor tissue. ursolic acid 0-2 signal transducer and activator of transcription 3 Homo sapiens 45-50 24122993-0 2013 Ursolic acid inhibits the growth of colon cancer-initiating cells by targeting STAT3. ursolic acid 0-12 signal transducer and activator of transcription 3 Homo sapiens 79-84 24122993-2 2013 In the present study we tested the efficacy of inhibiting STAT3 signaling in human colon cancer-initiating cells by ursolic acid (UA), which exists widely in fruits and herbs. ursolic acid 116-128 signal transducer and activator of transcription 3 Homo sapiens 58-63 24122993-2 2013 In the present study we tested the efficacy of inhibiting STAT3 signaling in human colon cancer-initiating cells by ursolic acid (UA), which exists widely in fruits and herbs. ursolic acid 130-132 signal transducer and activator of transcription 3 Homo sapiens 58-63 24122993-3 2013 RESULTS: Our data demonstrated that UA inhibited STAT3 phosphorylation, and induced caspase-3 cleavage of ALDH(+)/CD133(+) colon cancer-initiating cells. ursolic acid 36-38 signal transducer and activator of transcription 3 Homo sapiens 49-54 24122993-5 2013 UA also inhibited the activation of STAT3 induced by interleukin-6 in DLD-1 colon cancer cells. ursolic acid 0-2 signal transducer and activator of transcription 3 Homo sapiens 36-41 24122993-8 2013 UA, a dietary agent, might offer an effective approach for colorectal carcinoma prevention by inhibiting persistently activated STAT3 in cancer stem cells. ursolic acid 0-2 signal transducer and activator of transcription 3 Homo sapiens 128-133 17855663-0 2007 Ursolic acid inhibits STAT3 activation pathway leading to suppression of proliferation and chemosensitization of human multiple myeloma cells. ursolic acid 0-12 signal transducer and activator of transcription 3 Homo sapiens 22-27 17855663-3 2007 In the present report, we tested an agent, ursolic acid, found in basil, apples, prunes, and cranberries, for its ability to suppress STAT3 activation. ursolic acid 43-55 signal transducer and activator of transcription 3 Homo sapiens 134-139 17855663-4 2007 We found that ursolic acid, a pentacyclic triterpenoid, inhibited both constitutive and interleukin-6-inducible STAT3 activation in a dose- and time-dependent manner in multiple myeloma cells. ursolic acid 14-26 signal transducer and activator of transcription 3 Homo sapiens 112-117 17855663-6 2007 Vanadate treatment reversed the ursolic acid-induced down-regulation of STAT3, suggesting the involvement of a tyrosine phosphatase. ursolic acid 32-44 signal transducer and activator of transcription 3 Homo sapiens 72-77 33805840-0 2021 Antitumor Effects of Ursolic Acid through Mediating the Inhibition of STAT3/PD-L1 Signaling in Non-Small Cell Lung Cancer Cells. ursolic acid 21-33 signal transducer and activator of transcription 3 Homo sapiens 70-75 33805840-12 2021 Furthermore, UA reduced the expressions of vascular endothelial growth factor (VEGF), metalloproteinases (MMPs) and programmed death ligand-1 (PD-L1), as well as the formation of STAT3/MMP2 and STAT3/PD-L1 complexes. ursolic acid 13-15 signal transducer and activator of transcription 3 Homo sapiens 179-184 33805840-12 2021 Furthermore, UA reduced the expressions of vascular endothelial growth factor (VEGF), metalloproteinases (MMPs) and programmed death ligand-1 (PD-L1), as well as the formation of STAT3/MMP2 and STAT3/PD-L1 complexes. ursolic acid 13-15 signal transducer and activator of transcription 3 Homo sapiens 194-199 33805840-13 2021 Altogether, UA exhibits anticancer activities by inhibiting MMP2 and PD-L1 expression through EGFR/JAK2/STAT3 signaling. ursolic acid 12-14 signal transducer and activator of transcription 3 Homo sapiens 104-109 21465181-2 2011 In this study, we investigated the effect of ursolic acid (UA) on NF-kappaB and STAT3 signaling pathways in both androgen-independent (DU145) and androgen-dependent (LNCaP) prostate cancer cell lines and also prospectively tested the hypothesis of NF-kappaB and STAT3 inhibition using a virtual predictive functional proteomics tumor pathway technology platform. ursolic acid 45-57 signal transducer and activator of transcription 3 Homo sapiens 80-85 21465181-2 2011 In this study, we investigated the effect of ursolic acid (UA) on NF-kappaB and STAT3 signaling pathways in both androgen-independent (DU145) and androgen-dependent (LNCaP) prostate cancer cell lines and also prospectively tested the hypothesis of NF-kappaB and STAT3 inhibition using a virtual predictive functional proteomics tumor pathway technology platform. ursolic acid 59-61 signal transducer and activator of transcription 3 Homo sapiens 80-85 21465181-5 2011 Furthermore, UA suppressed both constitutive and inducible STAT3 activation in prostate cancer cells concomitant with suppression of activation of upstream kinases (Src and JAK2) and STAT3-dependent reporter gene activity. ursolic acid 13-15 signal transducer and activator of transcription 3 Homo sapiens 59-64 21465181-5 2011 Furthermore, UA suppressed both constitutive and inducible STAT3 activation in prostate cancer cells concomitant with suppression of activation of upstream kinases (Src and JAK2) and STAT3-dependent reporter gene activity. ursolic acid 13-15 signal transducer and activator of transcription 3 Homo sapiens 183-188 21465181-6 2011 UA also downregulated the expression of various NF-kappaB and STAT3 regulated gene products involved in proliferation, survival, and angiogenesis and induced apoptosis in both cells lines as evidenced by DNA fragmentation and annexin V staining. ursolic acid 0-2 signal transducer and activator of transcription 3 Homo sapiens 62-67 21465181-9 2011 Overall, our results from experimental and predictive studies suggest that UA mediates its anti-tumor effects through suppression of NF-kappaB and STAT3 pathways in prostate cancer. ursolic acid 75-77 signal transducer and activator of transcription 3 Homo sapiens 147-152 17855663-9 2007 Ursolic acid down-regulated the expression of STAT3-regulated gene products such as cyclin D1, Bcl-2, Bcl-xL, survivin, Mcl-1, and vascular endothelial growth factor. ursolic acid 0-12 signal transducer and activator of transcription 3 Homo sapiens 46-51 17855663-12 2007 Overall, these results suggest that ursolic acid is a novel blocker of STAT3 activation that may have a potential in prevention and treatment of multiple myeloma and other cancers. ursolic acid 36-48 signal transducer and activator of transcription 3 Homo sapiens 71-76