PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 26503559-0 2015 Ursolic Acid Induces Apoptosis of Prostate Cancer Cells via the PI3K/Akt/mTOR Pathway. ursolic acid 0-12 mechanistic target of rapamycin kinase Homo sapiens 73-77 25689721-1 2015 OBJECTIVE: To investigate the effect of ursolic acid on autophagy mediated through the miRNA-21-targeted phosphoinositide 3 kinase (PI3K)/protein kinase B (Akt)/mammalian target of rapamycin (mTOR) pathway in rat mesangial cells cultured under high glucose (HG) conditions. ursolic acid 40-52 mechanistic target of rapamycin kinase Homo sapiens 161-190 25689721-1 2015 OBJECTIVE: To investigate the effect of ursolic acid on autophagy mediated through the miRNA-21-targeted phosphoinositide 3 kinase (PI3K)/protein kinase B (Akt)/mammalian target of rapamycin (mTOR) pathway in rat mesangial cells cultured under high glucose (HG) conditions. ursolic acid 40-52 mechanistic target of rapamycin kinase Homo sapiens 192-196 26503559-6 2015 Treatment with UA also inhibited the expression of phosphatidylinositol-3-kinase (PI3K), phosphorylation of Akt and mTOR signaling proteins. ursolic acid 15-17 mechanistic target of rapamycin kinase Homo sapiens 116-120 26503559-8 2015 Our study demonstrates that UA not only inhibits cell growth but also induces apoptosis through modulation of the PI3K/Akt/mTOR pathway in human prostate cancer cells. ursolic acid 28-30 mechanistic target of rapamycin kinase Homo sapiens 123-127 22178132-7 2012 We also show that UA-induced autophagy in PC3 cells are mediated through the Beclin-1 and Akt/mTOR pathways. ursolic acid 18-20 mechanistic target of rapamycin kinase Homo sapiens 94-98 24802810-7 2014 The increase in free cytosolic calcium induced by UA activated the CaMKK-AMPK-mTOR kinase signaling cascade, which ultimately triggered autophagy. ursolic acid 50-52 mechanistic target of rapamycin kinase Homo sapiens 78-82 24740400-0 2014 Ursolic acid inhibits leucine-stimulated mTORC1 signaling by suppressing mTOR localization to lysosome. ursolic acid 0-12 mechanistic target of rapamycin kinase Homo sapiens 41-45 24740400-4 2014 The UA-mediated inhibition of mTORC1 is independent of Akt, tuberous sclerosis complex 1/2 (TSC1/2), and Ras homolog enriched in brain (Rheb), suggesting that UA negatively regulates mTORC1 signaling by targeting at a site downstream of these mTOR regulators. ursolic acid 4-6 mechanistic target of rapamycin kinase Homo sapiens 30-34 24740400-5 2014 UA treatment had no effect on the interaction between mTOR and its activator Raptor or inhibitor Deptor, but suppressed the binding of RagB to Raptor and inhibited leucine-induced mTOR lysosomal localization. ursolic acid 0-2 mechanistic target of rapamycin kinase Homo sapiens 180-184 23325562-5 2013 Interestingly, ursolic acid increased the phosphorylation of AMPK and coenzyme A carboxylase and also enhanced phosphorylation of GSK3beta at inactive form serine 9, whereas ursolic acid attenuated the phosphorylation of AKT and mTOR in HepG2 cells. ursolic acid 15-27 mechanistic target of rapamycin kinase Homo sapiens 229-233 23325562-5 2013 Interestingly, ursolic acid increased the phosphorylation of AMPK and coenzyme A carboxylase and also enhanced phosphorylation of GSK3beta at inactive form serine 9, whereas ursolic acid attenuated the phosphorylation of AKT and mTOR in HepG2 cells. ursolic acid 174-186 mechanistic target of rapamycin kinase Homo sapiens 229-233 31151763-0 2019 Inhibitory effects of ursolic acid from Bushen Yijing Formula on TGF-beta1-induced human umbilical vein endothelial cell fibrosis via AKT/mTOR signaling and Snail gene. ursolic acid 22-34 mechanistic target of rapamycin kinase Homo sapiens 138-142 34512368-3 2021 In this review, we focus on summarizing some representative natural active compounds, mainly including curcumin, resveratrol, paclitaxel, Bufalin, and Ursolic acid that may ultimately trigger cancer cell death through the regulation of some key autophagic signaling pathways, such as RAS-RAF-MEK-ERK, PI3K-AKT-mTOR, AMPK, ULK1, Beclin-1, Atg5 and p53. ursolic acid 151-163 mechanistic target of rapamycin kinase Homo sapiens 310-314 31062913-4 2019 UA induced caspase-dependent apoptosis accompanied with the modulation of various biological biomarkers including downregulating Akt/mTOR/NF-kappaB signaling, ERK, and p38. ursolic acid 0-2 mechanistic target of rapamycin kinase Homo sapiens 133-137 20352621-0 2010 Ursolic acid, a naturally occurring triterpenoid, suppresses migration and invasion of human breast cancer cells by modulating c-Jun N-terminal kinase, Akt and mammalian target of rapamycin signaling. ursolic acid 0-12 mechanistic target of rapamycin kinase Homo sapiens 160-189 20352621-5 2010 Ursolic acid suppressed the phosphorylation of Jun N-terminal kinase, Akt and mammalian target of rapamycin, but had no effect on the phosphorylation of ERK and p38. ursolic acid 0-12 mechanistic target of rapamycin kinase Homo sapiens 78-107 20352621-8 2010 In conclusion, we demonstrated that the anti-invasive effects of ursolic acid on MDAMB231 cells might be through the inhibition of Jun N-terminal kinase, Akt and mammalian target of rapamycin phosphorylation and a reduction of the level of NFkappaB protein in the nucleus, ultimately leading to downregulation of MMP-2 and u-PA expression. ursolic acid 65-77 mechanistic target of rapamycin kinase Homo sapiens 162-191 31547522-5 2019 Ursolic acid activates AKT/mTOR pathways and oleanolic acid triggers a pathway independent on AKT. ursolic acid 0-12 mechanistic target of rapamycin kinase Homo sapiens 27-31 31151763-6 2019 Slug, Snail, and Twist gene expression and phosphorylation of mammalian target of rapamycin (mTOR) and AKT altered by TGF-beta in HUVECs were suppressed by ursolic acid and drug-contained serum. ursolic acid 156-168 mechanistic target of rapamycin kinase Homo sapiens 62-91 31151763-6 2019 Slug, Snail, and Twist gene expression and phosphorylation of mammalian target of rapamycin (mTOR) and AKT altered by TGF-beta in HUVECs were suppressed by ursolic acid and drug-contained serum. ursolic acid 156-168 mechanistic target of rapamycin kinase Homo sapiens 93-97 31151763-9 2019 Ursolic acid from Bushen Yijing Formula inhibits human umbilical vein endothelial cell EndMT and fibrosis, mediated by AKT/mTOR signaling and Snail gene expression. ursolic acid 0-12 mechanistic target of rapamycin kinase Homo sapiens 123-127 29428962-0 2018 Ursolic Acid Attenuates High Glucose-Mediated Mesangial Cell Injury by Inhibiting the Phosphatidylinositol 3-Kinase/Akt/Mammalian Target of Rapamycin (PI3K/Akt/mTOR) Signaling Pathway. ursolic acid 0-12 mechanistic target of rapamycin kinase Homo sapiens 120-149 29428962-0 2018 Ursolic Acid Attenuates High Glucose-Mediated Mesangial Cell Injury by Inhibiting the Phosphatidylinositol 3-Kinase/Akt/Mammalian Target of Rapamycin (PI3K/Akt/mTOR) Signaling Pathway. ursolic acid 0-12 mechanistic target of rapamycin kinase Homo sapiens 160-164 29428962-9 2018 CONCLUSIONS UA attenuated mesangial cell proliferation and ROS generation by inhibiting HG-mediated PI3K/Akt/mTOR pathway activation, thereby ameliorating mesangial cell damage. ursolic acid 12-14 mechanistic target of rapamycin kinase Homo sapiens 109-113