PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
25213465-8	2014	Ursolic acid also suppressed TNBS-induced COX-2 and iNOS expression as well as NF-kappaB activation in colon tissues.	ursolic acid	0-12	cytochrome c oxidase II, mitochondrial	Mus musculus	42-47	
25168399-11	2015	Importantly, silence of LKB1, AMPK, or iNOS/Cox-2 by small interference RNA transfection reversed UA-induced effects in cultured cells.	ursolic acid	98-100	cytochrome c oxidase II, mitochondrial	Mus musculus	44-49	
26100520-4	2015	The combination of ursolic acid + resveratrol inhibited TPA-induced signaling pathways, including EGFR, STAT3, Src, Akt, Cox-2, Fas, NF-kappaB, p38 MAPK, c-Jun, and JNK1/2 while increasing levels of tumor suppressors, such as p21 and PDCD4, to a greater extent compared with the groups treated with the individual compounds.	ursolic acid	19-31	cytochrome c oxidase II, mitochondrial	Mus musculus	121-126	
24727148-7	2014	Furthermore, western blot analysis showed that UA significantly decreased CYP2E1 expression levels and production of pro-inflammatory markers including TNF-alpha, IL-1beta and COX-2 in CCl(4)-treated mouse liver.	ursolic acid	47-49	cytochrome c oxidase II, mitochondrial	Mus musculus	176-181	
22427843-7	2012	In addition, UA significantly down-regulated the expression levels of cyclin D1 and COX-2 but up-regulated the levels of caspase-3 as revealed by immunohistochemical analysis of tumor tissue sections.	ursolic acid	13-15	cytochrome c oxidase II, mitochondrial	Mus musculus	84-89	
20133359-7	2010	Furthermore, the results also showed that UA significantly reduced the number of activated microglia cells and astrocytes, decreased the expression of CD11b and glial fibrillary acidic protein, downregulated the expression of iNOS and COX-2, and decreased interleukin (IL)-1beta, IL-6, and tumor necrosis factor-alpha levels in the prefrontal cortex of D-gal-treated mice.	ursolic acid	42-44	cytochrome c oxidase II, mitochondrial	Mus musculus	235-240	
31083310-9	2019	Conclusions: 18beta glycyrrhetinic acid, isoliquiritigenin, and ursolic acid inhibited the gene expressions of ICAM-1, TNF-alpha, COX-2, and iNOS, partly through inhibiting NF-kappaB expression and attenuating NF-kappaB nuclear translocation.	ursolic acid	64-76	cytochrome c oxidase II, mitochondrial	Mus musculus	130-135	
16636478-2	2006	In this study, we found that topical applications of UA to mouse skin twice a week for 2 weeks significantly enhanced mRNA expression of cyclooxygenase (COX)-1, COX-2, and tumor necrosis factor-alpha, whereas its effect on tumor promotion was unclear.	ursolic acid	53-55	cytochrome c oxidase II, mitochondrial	Mus musculus	161-166	
9485026-6	1998	The 3-alpha(axial)-epimer of ursolic acid suppressed de novo formation of COX-2, in contrast to naturally occurring 3-beta(equatorial)-ursolic acid.	ursolic acid	29-41	cytochrome c oxidase II, mitochondrial	Mus musculus	74-79