PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 24399733-0 2013 Inhibition of Wnt/beta-catenin signaling mediates ursolic acid-induced apoptosis in PC-3 prostate cancer cells. ursolic acid 50-62 catenin beta 1 Homo sapiens 18-30 24399733-3 2013 To investigate the antitumor mechanism, the apoptotic mechanism of ursolic acid via Wnt/beta-catenin signaling was examined in PC-3 prostate cancer cells. ursolic acid 67-79 catenin beta 1 Homo sapiens 88-100 24399733-8 2013 Interestingly, ursolic acid suppressed the expression of Wnt5alpha/beta and beta-catenin, and enhanced the phosphorylation of glycogen synthase kinase 3 beta (GSK3beta). ursolic acid 15-27 catenin beta 1 Homo sapiens 76-88 24399733-10 2013 CONCLUSIONS: Our findings suggest that ursolic acid induces apoptosis via inhibition of the Wnt5/beta-catenin pathway and activation of caspase in PC-3 prostate cancer cells. ursolic acid 39-51 catenin beta 1 Homo sapiens 97-109 10938399-5 2000 These apoptotic effects of UA were accompanied by proteolytic cleavage of specific target proteins such as PARP, beta-catenin and Rad51 proteins suggesting the possible involvement of caspases. ursolic acid 27-29 catenin beta 1 Homo sapiens 113-125 22791147-8 2012 Interestingly, ursolic acid suppressed beta-catenin degradation as well as enhanced phosphorylation of glycogen synthase kinase 3 beta (GSK 3beta). ursolic acid 15-27 catenin beta 1 Homo sapiens 39-51 34141150-5 2021 Ursolic acid was found to be a significant inhibitor of cancer cells migration and gene expression of migration markers FN1, CDH2, CTNNB1 and TWIST was also downregulated. ursolic acid 0-12 catenin beta 1 Homo sapiens 131-137 34584036-0 2021 The Root Bark of Morus alba L. and Its Bioactive Ingredient, Ursolic Acid, Suppress the Proliferation of Multiple Myeloma Cells by Inhibiting the Wnt/beta-catenin Pathway. ursolic acid 61-73 catenin beta 1 Homo sapiens 150-162 34584036-6 2021 We identified ursolic acid in MRBE through LC/mass spectrum (MS) and observed that it also decreased intracellular beta-catenin, c-myc, and cyclin D1 levels. ursolic acid 14-26 catenin beta 1 Homo sapiens 115-127 34584036-8 2021 These findings suggest that MRBE and its active ingredient, ursolic acid, exert antiproliferative activity by promoting the degradation of beta-catenin and may have significant chemopreventive potential against MM. ursolic acid 60-72 catenin beta 1 Homo sapiens 139-151 31322286-12 2019 Moreover, UA significantly induces apoptosis and inhibits the proliferation of H1975 cells by negatively regulating the beta-catenin/TCF4/CT45A2 signaling pathway. ursolic acid 10-12 catenin beta 1 Homo sapiens 120-132 27665868-11 2016 Our findings indicated that UA can inhibit the proliferation of 143B OS cells through inactivation of Wnt/beta-catenin signaling, which may be mediated partly by upregulating the expression of p53. ursolic acid 28-30 catenin beta 1 Homo sapiens 106-118 27665868-0 2016 Ursolic acid inhibits proliferation and induces apoptosis by inactivating Wnt/beta-catenin signaling in human osteosarcoma cells. ursolic acid 0-12 catenin beta 1 Homo sapiens 78-90 27665868-6 2016 Using a luciferase reporter assay, we found that the Wnt/beta-catenin signaling is inhibited by UA in 143B cells. ursolic acid 96-98 catenin beta 1 Homo sapiens 57-69 27665868-8 2016 Exogenous expression of beta-catenin attenuates the anticancer effect of UA in 143B cells, while knockdown of beta-catenin enhances this effect. ursolic acid 73-75 catenin beta 1 Homo sapiens 24-36 27665868-10 2016 Moreover, inhibition of p53 partly reverses the UA-induced downregulation of beta-catenin, as do the targets of Wnt/beta-catenin signaling, such as c-Myc and cyclin D1. ursolic acid 48-50 catenin beta 1 Homo sapiens 77-89 27665868-10 2016 Moreover, inhibition of p53 partly reverses the UA-induced downregulation of beta-catenin, as do the targets of Wnt/beta-catenin signaling, such as c-Myc and cyclin D1. ursolic acid 48-50 catenin beta 1 Homo sapiens 116-128 28090191-4 2016 Also, ursolic acid treatment accumulated the sub-G1 population, attenuated the expression of procapase 9, cyclin D1, pAKT, p-glycogen synthase kinase 3-alpha/beta (pGSK3alpha/beta), beta-catenin and nuclear factor kappa-light-chain-enhancer of activated B cells (NFkB) and also cleaved caspase 3 and poly (ADP-ribose) polymerase (PARP) in mesothelioma cells. ursolic acid 6-18 catenin beta 1 Homo sapiens 182-194 28090191-7 2016 Furthermore, overexpression of let 7b using let-7b mimics enhanced the antitumor effect of ursolic acid to attenuate the expression of procaspases 3, pro-PARP, pAKT, beta-catenin and Twist and increase sub-G1 accumulation in H2452 mesothelioma cells. ursolic acid 91-103 catenin beta 1 Homo sapiens 166-178 27219337-4 2016 UA treatment (6-9 h) strongly blocked the survival AKT/GSK3beta/beta-catenin signalling pathway, which led to a concomitant reduction of the anti-apoptotic proteins c-Myc and p21, altogether resulting in the activation of intrinsic apoptosis. ursolic acid 0-2 catenin beta 1 Homo sapiens 64-76 24566423-0 2014 Ursolic acid and its natural derivative corosolic acid suppress the proliferation of APC-mutated colon cancer cells through promotion of beta-catenin degradation. ursolic acid 0-12 catenin beta 1 Homo sapiens 137-149 24566423-2 2014 Here we used a cell-based reporter system for detection of beta-catenin response transcription (CRT) to identify UA as an antagonist of the Wnt/beta-catenin pathway. ursolic acid 113-115 catenin beta 1 Homo sapiens 59-71 24566423-2 2014 Here we used a cell-based reporter system for detection of beta-catenin response transcription (CRT) to identify UA as an antagonist of the Wnt/beta-catenin pathway. ursolic acid 113-115 catenin beta 1 Homo sapiens 144-156 24566423-3 2014 UA promoted the degradation of intracellular beta-catenin that was accompanied by its N-terminal phosphorylation at Ser33/37/Thr41 residues, marking it for proteasomal degradation. ursolic acid 0-2 catenin beta 1 Homo sapiens 45-57 24566423-4 2014 Consistently, UA down-regulated the intracellular beta-catenin level in colon cancer cells with inactivating mutations of adenomatous polyposis coli (APC). ursolic acid 14-16 catenin beta 1 Homo sapiens 50-62 24566423-6 2014 The functional group analysis revealed that the major structural requirements for UA-mediated beta-catenin degradation are a carboxyl group at position 17 and a methyl group at position 19. ursolic acid 82-84 catenin beta 1 Homo sapiens 94-106 24566423-8 2014 Our findings suggest that UA and CA exert their anticancer activities against colon cancer cells by promoting the N-terminal phosphorylation and subsequent proteasomal degradation of beta-catenin. ursolic acid 26-28 catenin beta 1 Homo sapiens 183-195